Recent Advances in the Development of Exogenous dsRNA for the Induction of RNA Interference in Cancer Therapy

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Recent Advances in the Development of Exogenous dsRNA for the Induction of RNA Interference in Cancer Therapy. / Golubeva, Tatiana S.; Cherenko, Viktoria A.; Orishchenko, Konstantin E.

In: Molecules (Basel, Switzerland), Vol. 26, No. 3, 701, 29.01.2021.

Research output: Contribution to journal › Review article › peer-review

BibTeX

@article{c7fe05155f84473388c4b39a4b89b852,

title = "Recent Advances in the Development of Exogenous dsRNA for the Induction of RNA Interference in Cancer Therapy",

abstract = "Selective regulation of gene expression by means of RNA interference has revolutionized molecular biology. This approach is not only used in fundamental studies on the roles of particular genes in the functioning of various organisms, but also possesses practical applications. A variety of methods are being developed based on gene silencing using dsRNA-for protecting agricultural plants from various pathogens, controlling insect reproduction, and therapeutic techniques related to the oncological disease treatment. One of the main problems in this research area is the successful delivery of exogenous dsRNA into cells, as this can be greatly affected by the localization or origin of tumor. This overview is dedicated to describing the latest advances in the development of various transport agents for the delivery of dsRNA fragments for gene silencing, with an emphasis on cancer treatment.",

keywords = "cancer, delivery agents, exogenous dsRNA, oligonucleotides, RNA interference, RNA Interference, Humans, Gene Silencing, RNA, Double-Stranded/genetics, Neoplasms/genetics, Oligonucleotides, Exogenous dsRNA, Delivery agents, Cancer",

author = "Golubeva, {Tatiana S.} and Cherenko, {Viktoria A.} and Orishchenko, {Konstantin E.}",

note = "Funding Information: Funding: This research was funded by Ministry of Education and Science of Russian Federation, grant #2019-0546 (FSUS-2020-0040). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = jan,

day = "29",

doi = "10.3390/molecules26030701",

language = "English",

volume = "26",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "3",

}

RIS

TY - JOUR

T1 - Recent Advances in the Development of Exogenous dsRNA for the Induction of RNA Interference in Cancer Therapy

AU - Golubeva, Tatiana S.

AU - Cherenko, Viktoria A.

AU - Orishchenko, Konstantin E.

N1 - Funding Information: Funding: This research was funded by Ministry of Education and Science of Russian Federation, grant #2019-0546 (FSUS-2020-0040). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/1/29

Y1 - 2021/1/29

N2 - Selective regulation of gene expression by means of RNA interference has revolutionized molecular biology. This approach is not only used in fundamental studies on the roles of particular genes in the functioning of various organisms, but also possesses practical applications. A variety of methods are being developed based on gene silencing using dsRNA-for protecting agricultural plants from various pathogens, controlling insect reproduction, and therapeutic techniques related to the oncological disease treatment. One of the main problems in this research area is the successful delivery of exogenous dsRNA into cells, as this can be greatly affected by the localization or origin of tumor. This overview is dedicated to describing the latest advances in the development of various transport agents for the delivery of dsRNA fragments for gene silencing, with an emphasis on cancer treatment.

AB - Selective regulation of gene expression by means of RNA interference has revolutionized molecular biology. This approach is not only used in fundamental studies on the roles of particular genes in the functioning of various organisms, but also possesses practical applications. A variety of methods are being developed based on gene silencing using dsRNA-for protecting agricultural plants from various pathogens, controlling insect reproduction, and therapeutic techniques related to the oncological disease treatment. One of the main problems in this research area is the successful delivery of exogenous dsRNA into cells, as this can be greatly affected by the localization or origin of tumor. This overview is dedicated to describing the latest advances in the development of various transport agents for the delivery of dsRNA fragments for gene silencing, with an emphasis on cancer treatment.

KW - cancer

KW - delivery agents

KW - exogenous dsRNA

KW - oligonucleotides

KW - RNA interference

KW - RNA Interference

KW - Humans

KW - Gene Silencing

KW - RNA, Double-Stranded/genetics

KW - Neoplasms/genetics

KW - Oligonucleotides

KW - Exogenous dsRNA

KW - Delivery agents

KW - Cancer

UR - http://www.scopus.com/inward/record.url?scp=85101458858&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/4bc7c326-71af-3b2b-b06d-908d524908f6/

U2 - 10.3390/molecules26030701

DO - 10.3390/molecules26030701

M3 - Review article

C2 - 33572762

AN - SCOPUS:85101458858

VL - 26

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 3

M1 - 701

ER -

ID: 28041529