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Reactive oxygen species-mediated autophagy defines the fate of cancer stem cells. / Lleonart, Matilde E.; Abad, Etna; Graifer, Dmitry et al.

In: Antioxidants and Redox Signaling, Vol. 28, No. 11, 10.04.2018, p. 1066-1079.

Research output: Contribution to journal › Review article › peer-review

Harvard

Lleonart, ME, Abad, E, Graifer, D & Lyakhovich, A 2018, 'Reactive oxygen species-mediated autophagy defines the fate of cancer stem cells', Antioxidants and Redox Signaling, vol. 28, no. 11, pp. 1066-1079. https://doi.org/10.1089/ars.2017.7223

APA

Lleonart, M. E., Abad, E., Graifer, D., & Lyakhovich, A. (2018). Reactive oxygen species-mediated autophagy defines the fate of cancer stem cells. Antioxidants and Redox Signaling, 28(11), 1066-1079. https://doi.org/10.1089/ars.2017.7223

Vancouver

Lleonart ME, Abad E, Graifer D, Lyakhovich A. Reactive oxygen species-mediated autophagy defines the fate of cancer stem cells. Antioxidants and Redox Signaling. 2018 Apr 10;28(11):1066-1079. doi: 10.1089/ars.2017.7223

Author

Lleonart, Matilde E. ; Abad, Etna ; Graifer, Dmitry et al. / Reactive oxygen species-mediated autophagy defines the fate of cancer stem cells. In: Antioxidants and Redox Signaling. 2018 ; Vol. 28, No. 11. pp. 1066-1079.

BibTeX

@article{f1f4ce7875a9409e8ce03fdc98aaf08d,
title = "Reactive oxygen species-mediated autophagy defines the fate of cancer stem cells",
abstract = "Significance: A fraction of tumorigenic cells, also known as tumor initiating or cancer stem cells (CSCs), is thought to drive tumor growth, metastasis, and chemoresistance. However, little is known regarding mechanisms that convey relevant pathways contributing to their self-renewal, proliferation, and differentiation abilities. Recent Advances: Recent works on CSCs provide evidence on the role of redox disruption and regulation of autophagic flux. This has been linked to increased DNA repair capacity and chemoresistance. Critical Issues: The current review summarizes the most recent studies assessing the role of redox homeostasis, autophagy, and chemoresistance in CSCs, including some novel findings on microRNAs and their role in horizontal transfer within cancer cell populations. Future Directions: Rational anticancer therapy and prevention should rely on the fact that cancer is a redox disease with the CSCs being the apex modulated by redox-mediated autophagy.",
keywords = "autophagy, cancer stem cells, DNA damage and repair, exosomes, ferroptosis, mitochondria",
author = "Lleonart, {Matilde E.} and Etna Abad and Dmitry Graifer and Alex Lyakhovich",
year = "2018",
month = apr,
day = "10",
doi = "10.1089/ars.2017.7223",
language = "English",
volume = "28",
pages = "1066--1079",
journal = "Antioxidants and Redox Signaling",
issn = "1523-0864",
publisher = "Mary Ann Liebert Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - Reactive oxygen species-mediated autophagy defines the fate of cancer stem cells

AU - Lleonart, Matilde E.

AU - Abad, Etna

AU - Graifer, Dmitry

AU - Lyakhovich, Alex

PY - 2018/4/10

Y1 - 2018/4/10

N2 - Significance: A fraction of tumorigenic cells, also known as tumor initiating or cancer stem cells (CSCs), is thought to drive tumor growth, metastasis, and chemoresistance. However, little is known regarding mechanisms that convey relevant pathways contributing to their self-renewal, proliferation, and differentiation abilities. Recent Advances: Recent works on CSCs provide evidence on the role of redox disruption and regulation of autophagic flux. This has been linked to increased DNA repair capacity and chemoresistance. Critical Issues: The current review summarizes the most recent studies assessing the role of redox homeostasis, autophagy, and chemoresistance in CSCs, including some novel findings on microRNAs and their role in horizontal transfer within cancer cell populations. Future Directions: Rational anticancer therapy and prevention should rely on the fact that cancer is a redox disease with the CSCs being the apex modulated by redox-mediated autophagy.

AB - Significance: A fraction of tumorigenic cells, also known as tumor initiating or cancer stem cells (CSCs), is thought to drive tumor growth, metastasis, and chemoresistance. However, little is known regarding mechanisms that convey relevant pathways contributing to their self-renewal, proliferation, and differentiation abilities. Recent Advances: Recent works on CSCs provide evidence on the role of redox disruption and regulation of autophagic flux. This has been linked to increased DNA repair capacity and chemoresistance. Critical Issues: The current review summarizes the most recent studies assessing the role of redox homeostasis, autophagy, and chemoresistance in CSCs, including some novel findings on microRNAs and their role in horizontal transfer within cancer cell populations. Future Directions: Rational anticancer therapy and prevention should rely on the fact that cancer is a redox disease with the CSCs being the apex modulated by redox-mediated autophagy.

KW - autophagy

KW - cancer stem cells

KW - DNA damage and repair

KW - exosomes

KW - ferroptosis

KW - mitochondria

UR - http://www.scopus.com/inward/record.url?scp=85046606268&partnerID=8YFLogxK

U2 - 10.1089/ars.2017.7223

DO - 10.1089/ars.2017.7223

M3 - Review article

C2 - 28683561

AN - SCOPUS:85046606268

VL - 28

SP - 1066

EP - 1079

JO - Antioxidants and Redox Signaling

JF - Antioxidants and Redox Signaling

SN - 1523-0864

IS - 11

ER -

ID: 16083229