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Rapid emergence of independent "chromosomal lineages" in silvered-leaf monkey triggered by Y/autosome translocation. / Capozzi, Oronzo; Stanyon, Roscoe; Archidiacono, Nicoletta et al.

In: Scientific Reports, Vol. 8, No. 1, 3250, 19.02.2018, p. 3250.

Research output: Contribution to journalArticlepeer-review

Harvard

Capozzi, O, Stanyon, R, Archidiacono, N, Ishida, T, Romanenko, SA & Rocchi, M 2018, 'Rapid emergence of independent "chromosomal lineages" in silvered-leaf monkey triggered by Y/autosome translocation', Scientific Reports, vol. 8, no. 1, 3250, pp. 3250. https://doi.org/10.1038/s41598-018-21509-4

APA

Capozzi, O., Stanyon, R., Archidiacono, N., Ishida, T., Romanenko, S. A., & Rocchi, M. (2018). Rapid emergence of independent "chromosomal lineages" in silvered-leaf monkey triggered by Y/autosome translocation. Scientific Reports, 8(1), 3250. [3250]. https://doi.org/10.1038/s41598-018-21509-4

Vancouver

Capozzi O, Stanyon R, Archidiacono N, Ishida T, Romanenko SA, Rocchi M. Rapid emergence of independent "chromosomal lineages" in silvered-leaf monkey triggered by Y/autosome translocation. Scientific Reports. 2018 Feb 19;8(1):3250. 3250. doi: 10.1038/s41598-018-21509-4

Author

Capozzi, Oronzo ; Stanyon, Roscoe ; Archidiacono, Nicoletta et al. / Rapid emergence of independent "chromosomal lineages" in silvered-leaf monkey triggered by Y/autosome translocation. In: Scientific Reports. 2018 ; Vol. 8, No. 1. pp. 3250.

BibTeX

@article{0bf4b1706d8e4895ac77c54755c5b619,
title = "Rapid emergence of independent {"}chromosomal lineages{"} in silvered-leaf monkey triggered by Y/autosome translocation",
abstract = "Sex/autosome translocations are rare events. The only known example in catarrhines is in the silvered-leaf monkey. Here the Y chromosome was reciprocally translocated with chromosome 1. The rearrangement produced an X1X2Y1Y2 sex chromosome system. At least three chromosomal variants of the intact chromosome 1 are known to exist. We characterized in high resolution the translocation products (Y1 and Y2) and the polymorphic forms of the intact chromosome 1 with a panel of more than 150 human BAC clones. We showed that the translocation products were extremely rearranged, in contrast to the high level of marker order conservation of the other silvered-leaf monkey chromosomes. Surprisingly, each translocation product appeared to form independent {"}chromosome lineages{"}; each having a myriad of distinct rearrangements. We reconstructed the evolutionary history of the translocation products by comparing the homologous chromosomes of two other colobine species: the African mantled guereza and the Indian langur. The results showed a massive reuse of breakpoints: only 12, out of the 40 breaks occurred in domains never reused in other rearrangements, while, strikingly, some domains were used up to four times. Such frequent breakpoint reuse if proved to be a general phenomenon has profound implications for mechanisms of chromosome evolution.",
keywords = "CENTROMERE, COLOBINAE, EVOLUTIONARY HISTORY, HOMOLOGY, HUMAN GENOME, IN-SITU HYBRIDIZATION, KARYOTYPE, PRESBYTIS-CRISTATUS, PRIMATES, REARRANGEMENTS",
author = "Oronzo Capozzi and Roscoe Stanyon and Nicoletta Archidiacono and Takafumi Ishida and Romanenko, {Svetlana A.} and Mariano Rocchi",
note = "Publisher Copyright: {\textcopyright} 2018 The Author(s).",
year = "2018",
month = feb,
day = "19",
doi = "10.1038/s41598-018-21509-4",
language = "English",
volume = "8",
pages = "3250",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Rapid emergence of independent "chromosomal lineages" in silvered-leaf monkey triggered by Y/autosome translocation

AU - Capozzi, Oronzo

AU - Stanyon, Roscoe

AU - Archidiacono, Nicoletta

AU - Ishida, Takafumi

AU - Romanenko, Svetlana A.

AU - Rocchi, Mariano

N1 - Publisher Copyright: © 2018 The Author(s).

PY - 2018/2/19

Y1 - 2018/2/19

N2 - Sex/autosome translocations are rare events. The only known example in catarrhines is in the silvered-leaf monkey. Here the Y chromosome was reciprocally translocated with chromosome 1. The rearrangement produced an X1X2Y1Y2 sex chromosome system. At least three chromosomal variants of the intact chromosome 1 are known to exist. We characterized in high resolution the translocation products (Y1 and Y2) and the polymorphic forms of the intact chromosome 1 with a panel of more than 150 human BAC clones. We showed that the translocation products were extremely rearranged, in contrast to the high level of marker order conservation of the other silvered-leaf monkey chromosomes. Surprisingly, each translocation product appeared to form independent "chromosome lineages"; each having a myriad of distinct rearrangements. We reconstructed the evolutionary history of the translocation products by comparing the homologous chromosomes of two other colobine species: the African mantled guereza and the Indian langur. The results showed a massive reuse of breakpoints: only 12, out of the 40 breaks occurred in domains never reused in other rearrangements, while, strikingly, some domains were used up to four times. Such frequent breakpoint reuse if proved to be a general phenomenon has profound implications for mechanisms of chromosome evolution.

AB - Sex/autosome translocations are rare events. The only known example in catarrhines is in the silvered-leaf monkey. Here the Y chromosome was reciprocally translocated with chromosome 1. The rearrangement produced an X1X2Y1Y2 sex chromosome system. At least three chromosomal variants of the intact chromosome 1 are known to exist. We characterized in high resolution the translocation products (Y1 and Y2) and the polymorphic forms of the intact chromosome 1 with a panel of more than 150 human BAC clones. We showed that the translocation products were extremely rearranged, in contrast to the high level of marker order conservation of the other silvered-leaf monkey chromosomes. Surprisingly, each translocation product appeared to form independent "chromosome lineages"; each having a myriad of distinct rearrangements. We reconstructed the evolutionary history of the translocation products by comparing the homologous chromosomes of two other colobine species: the African mantled guereza and the Indian langur. The results showed a massive reuse of breakpoints: only 12, out of the 40 breaks occurred in domains never reused in other rearrangements, while, strikingly, some domains were used up to four times. Such frequent breakpoint reuse if proved to be a general phenomenon has profound implications for mechanisms of chromosome evolution.

KW - CENTROMERE

KW - COLOBINAE

KW - EVOLUTIONARY HISTORY

KW - HOMOLOGY

KW - HUMAN GENOME

KW - IN-SITU HYBRIDIZATION

KW - KARYOTYPE

KW - PRESBYTIS-CRISTATUS

KW - PRIMATES

KW - REARRANGEMENTS

UR - http://www.scopus.com/inward/record.url?scp=85042232875&partnerID=8YFLogxK

U2 - 10.1038/s41598-018-21509-4

DO - 10.1038/s41598-018-21509-4

M3 - Article

C2 - 29459623

AN - SCOPUS:85042232875

VL - 8

SP - 3250

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 3250

ER -

ID: 12078819