Research output: Contribution to journal › Article › peer-review
Prospects for the Development of Anti-Influenza Drugs Based on Medicinal Mushrooms (Review). / Teplyakova, T. V.; Ilyicheva, T. N.; Markovich, N. A.
In: Applied Biochemistry and Microbiology, Vol. 56, No. 5, 01.09.2020, p. 489-496.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Prospects for the Development of Anti-Influenza Drugs Based on Medicinal Mushrooms (Review)
AU - Teplyakova, T. V.
AU - Ilyicheva, T. N.
AU - Markovich, N. A.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Russian and international publications on the antiviral activity of medicinal mushrooms against influenza, which have been studied in cell culture and animal models, on the presence of sialidase (neuraminidase) inhibitors and RNA polymerase inhibitors of influenza virus are considered. The activity against influenza of both aqueous extracts of higher fungi and the polysaccharides, peptidoglycans, proteins, melanin, polyphenols, and terpenoids present in them is described. It is noted that further studies of the antiviral mechanisms of these components of medicinal mushrooms, both those grown in natural conditions and those cultivated with solid-phase or submerged methods in laboratory and factory conditions, are required in order to develop drugs based on them.
AB - Russian and international publications on the antiviral activity of medicinal mushrooms against influenza, which have been studied in cell culture and animal models, on the presence of sialidase (neuraminidase) inhibitors and RNA polymerase inhibitors of influenza virus are considered. The activity against influenza of both aqueous extracts of higher fungi and the polysaccharides, peptidoglycans, proteins, melanin, polyphenols, and terpenoids present in them is described. It is noted that further studies of the antiviral mechanisms of these components of medicinal mushrooms, both those grown in natural conditions and those cultivated with solid-phase or submerged methods in laboratory and factory conditions, are required in order to develop drugs based on them.
KW - Basidiomycota
KW - cultivation
KW - influenza virus
KW - inhibition
KW - medicinal mushrooms
KW - melanin
KW - neuraminidase
KW - polyphenols
KW - polysaccharides
KW - RNA polymerase
KW - sialidase
KW - terpenoids
KW - IMMUNE-RESPONSE
KW - FRUITING BODY
KW - INFLUENZA
KW - PHYSICOCHEMICAL PROPERTIES
KW - SUPPLEMENTATION
KW - CORRELATED COMPOUND IMPROVES
KW - IN-VITRO
KW - NEURAMINIDASE INHIBITORS
KW - ANTIVIRAL ACTIVITY
KW - POLYSACCHARIDE
UR - http://www.scopus.com/inward/record.url?scp=85091320726&partnerID=8YFLogxK
U2 - 10.1134/S0003683820050142
DO - 10.1134/S0003683820050142
M3 - Article
AN - SCOPUS:85091320726
VL - 56
SP - 489
EP - 496
JO - Applied Biochemistry and Microbiology
JF - Applied Biochemistry and Microbiology
SN - 0003-6838
IS - 5
ER -
ID: 25645119