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Pro-social and anxiolytic-like behavior following a single 24-h exposure to 17β-estradiol in adult male zebrafish. / Moraes, Andréia B.; Giacomini, Ana C.V.V.; Genario, Rafael et al.

In: Neuroscience Letters, Vol. 747, 135591, 16.03.2021.

Research output: Contribution to journal › Article › peer-review

Harvard

Moraes, AB, Giacomini, ACVV, Genario, R, Marcon, L, Scolari, N, Bueno, BW, Demin, KA, Amstislavskaya, TG, Strekalova, T, Soares, MC, de Abreu, MS & Kalueff, AV 2021, 'Pro-social and anxiolytic-like behavior following a single 24-h exposure to 17β-estradiol in adult male zebrafish', Neuroscience Letters, vol. 747, 135591. https://doi.org/10.1016/j.neulet.2020.135591

APA

Moraes, A. B., Giacomini, A. C. V. V., Genario, R., Marcon, L., Scolari, N., Bueno, B. W., Demin, K. A., Amstislavskaya, T. G., Strekalova, T., Soares, M. C., de Abreu, M. S., & Kalueff, A. V. (2021). Pro-social and anxiolytic-like behavior following a single 24-h exposure to 17β-estradiol in adult male zebrafish. Neuroscience Letters, 747, [135591]. https://doi.org/10.1016/j.neulet.2020.135591

Vancouver

Moraes AB, Giacomini ACVV, Genario R, Marcon L, Scolari N, Bueno BW et al. Pro-social and anxiolytic-like behavior following a single 24-h exposure to 17β-estradiol in adult male zebrafish. Neuroscience Letters. 2021 Mar 16;747:135591. doi: 10.1016/j.neulet.2020.135591

Author

Moraes, Andréia B. ; Giacomini, Ana C.V.V. ; Genario, Rafael et al. / Pro-social and anxiolytic-like behavior following a single 24-h exposure to 17β-estradiol in adult male zebrafish. In: Neuroscience Letters. 2021 ; Vol. 747.

BibTeX

@article{0a87d242c8d9438e867a2bbd9d3614c5,
title = "Pro-social and anxiolytic-like behavior following a single 24-h exposure to 17β-estradiol in adult male zebrafish",
abstract = "Estradiol (17β-estradiol, E2) is a crucial estrogen hormone that regulates sexual, cognitive, social and affective behaviors in various species. However, complex central nervous system (CNS) effects of E2, including its activity in males, remain poorly understood. The zebrafish (Danio rerio) is rapidly becoming a powerful novel model system in translational neuroscience research. Here, we evaluate the effects of a single 24-h exposure to 20 μg/L of E2 on behavioral and endocrine (cortisol) responses in adult male zebrafish. Overall, E2 exerted pro-social effect in the social preference test, reduced whole-body cortisol levels, elevated exploration in the novel tank test and increased the shoal size in the shoaling test, indicative of an anxiolytic-like profile of this hormone in male zebrafish. Supporting mounting human and rodent evidence on the role of E2 in behavioral regulation, the observed pro-social and anxiolytic-like effects of E2 in male zebrafish reinforce the use of this aquatic organism in studying steroid-mediated CNS mechanisms of complex affective and social behaviors.",
keywords = "Anxiety, Anxiety-like behavior, Cortisol, Estrogens, Social behavior",
author = "Moraes, {Andr{\'e}ia B.} and Giacomini, {Ana C.V.V.} and Rafael Genario and Leticia Marcon and Naiara Scolari and Bueno, {Barbara W.} and Demin, {Konstantin A.} and Amstislavskaya, {Tamara G.} and Tatyana Strekalova and Soares, {Marta C.} and {de Abreu}, {Murilo S.} and Kalueff, {Allan V.}",
note = "Funding Information: ACVVG is supported by the Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado do Rio Grande do Sul (FAPERGS) research fellowships 17/2551-0001-269-0 . AVK is supported by the Zebrafish Platform Construction Fund from the Southwest University (Chongqing, China) . He chairs the International Zebrafish Neuroscience Research Consortium (ZNRC) that coordinated this multi-laboratory project. The collaboration was supported by the Russian Science Foundation (RSF) grant 19-15-00053 . KAD is supported by the President of Russia Graduate Fellowship , and the Special Rector{\textquoteright}s Fellowship for St. Petersburg State University students. TGA is supported by the budgetary state funding for basic research (AAAA-A16-116021010228-0) from the Scientific Research Institute of Neurosciences and Medicine (Novosibirsk, Russia) . The authors thank Sirlei Cazarotto (University of Passo Fundo, Brazil) for her assistance with experimental procedures, and Prof. Denis B. Rosemberg and Luiz V. C. da Rosa (Federal University of Santa Maria, Brazil) for advice and assistance with analyzing shoaling data. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = mar,
day = "16",
doi = "10.1016/j.neulet.2020.135591",
language = "English",
volume = "747",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Pro-social and anxiolytic-like behavior following a single 24-h exposure to 17β-estradiol in adult male zebrafish

AU - Moraes, Andréia B.

AU - Giacomini, Ana C.V.V.

AU - Genario, Rafael

AU - Marcon, Leticia

AU - Scolari, Naiara

AU - Bueno, Barbara W.

AU - Demin, Konstantin A.

AU - Amstislavskaya, Tamara G.

AU - Strekalova, Tatyana

AU - Soares, Marta C.

AU - de Abreu, Murilo S.

AU - Kalueff, Allan V.

N1 - Funding Information: ACVVG is supported by the Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) research fellowships 17/2551-0001-269-0 . AVK is supported by the Zebrafish Platform Construction Fund from the Southwest University (Chongqing, China) . He chairs the International Zebrafish Neuroscience Research Consortium (ZNRC) that coordinated this multi-laboratory project. The collaboration was supported by the Russian Science Foundation (RSF) grant 19-15-00053 . KAD is supported by the President of Russia Graduate Fellowship , and the Special Rector’s Fellowship for St. Petersburg State University students. TGA is supported by the budgetary state funding for basic research (AAAA-A16-116021010228-0) from the Scientific Research Institute of Neurosciences and Medicine (Novosibirsk, Russia) . The authors thank Sirlei Cazarotto (University of Passo Fundo, Brazil) for her assistance with experimental procedures, and Prof. Denis B. Rosemberg and Luiz V. C. da Rosa (Federal University of Santa Maria, Brazil) for advice and assistance with analyzing shoaling data. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2020 Elsevier B.V. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/3/16

Y1 - 2021/3/16

N2 - Estradiol (17β-estradiol, E2) is a crucial estrogen hormone that regulates sexual, cognitive, social and affective behaviors in various species. However, complex central nervous system (CNS) effects of E2, including its activity in males, remain poorly understood. The zebrafish (Danio rerio) is rapidly becoming a powerful novel model system in translational neuroscience research. Here, we evaluate the effects of a single 24-h exposure to 20 μg/L of E2 on behavioral and endocrine (cortisol) responses in adult male zebrafish. Overall, E2 exerted pro-social effect in the social preference test, reduced whole-body cortisol levels, elevated exploration in the novel tank test and increased the shoal size in the shoaling test, indicative of an anxiolytic-like profile of this hormone in male zebrafish. Supporting mounting human and rodent evidence on the role of E2 in behavioral regulation, the observed pro-social and anxiolytic-like effects of E2 in male zebrafish reinforce the use of this aquatic organism in studying steroid-mediated CNS mechanisms of complex affective and social behaviors.

AB - Estradiol (17β-estradiol, E2) is a crucial estrogen hormone that regulates sexual, cognitive, social and affective behaviors in various species. However, complex central nervous system (CNS) effects of E2, including its activity in males, remain poorly understood. The zebrafish (Danio rerio) is rapidly becoming a powerful novel model system in translational neuroscience research. Here, we evaluate the effects of a single 24-h exposure to 20 μg/L of E2 on behavioral and endocrine (cortisol) responses in adult male zebrafish. Overall, E2 exerted pro-social effect in the social preference test, reduced whole-body cortisol levels, elevated exploration in the novel tank test and increased the shoal size in the shoaling test, indicative of an anxiolytic-like profile of this hormone in male zebrafish. Supporting mounting human and rodent evidence on the role of E2 in behavioral regulation, the observed pro-social and anxiolytic-like effects of E2 in male zebrafish reinforce the use of this aquatic organism in studying steroid-mediated CNS mechanisms of complex affective and social behaviors.

KW - Anxiety

KW - Anxiety-like behavior

KW - Cortisol

KW - Estrogens

KW - Social behavior

UR - http://www.scopus.com/inward/record.url?scp=85101851809&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2020.135591

DO - 10.1016/j.neulet.2020.135591

M3 - Article

C2 - 33359732

AN - SCOPUS:85101851809

VL - 747

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

M1 - 135591

ER -

ID: 28004514