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Primary photochemical processes for Pt(IV) diazido complexes prospectIVe in photodynamic therapy of tumors. / Shushakov, Anton A.; Pozdnyakov, Ivan P.; Grivin, Vjacheslav P. et al.

In: Dalton Transactions, Vol. 46, No. 29, 25.07.2017, p. 9440-9450.

Research output: Contribution to journal › Article › peer-review

Harvard

Shushakov, AA, Pozdnyakov, IP, Grivin, VP, Plyusnin, VF, Vasilchenko, DB, Zadesenets, AV, Melnikov, AA, Chekalin, SV & Glebov, EM 2017, 'Primary photochemical processes for Pt(IV) diazido complexes prospectIVe in photodynamic therapy of tumors', Dalton Transactions, vol. 46, no. 29, pp. 9440-9450. https://doi.org/10.1039/c7dt01529a

APA

Shushakov, A. A., Pozdnyakov, I. P., Grivin, V. P., Plyusnin, V. F., Vasilchenko, D. B., Zadesenets, A. V., Melnikov, A. A., Chekalin, S. V., & Glebov, E. M. (2017). Primary photochemical processes for Pt(IV) diazido complexes prospectIVe in photodynamic therapy of tumors. Dalton Transactions, 46(29), 9440-9450. https://doi.org/10.1039/c7dt01529a

Vancouver

Shushakov AA, Pozdnyakov IP, Grivin VP, Plyusnin VF, Vasilchenko DB, Zadesenets AV et al. Primary photochemical processes for Pt(IV) diazido complexes prospectIVe in photodynamic therapy of tumors. Dalton Transactions. 2017 Jul 25;46(29):9440-9450. doi: 10.1039/c7dt01529a

Author

Shushakov, Anton A. ; Pozdnyakov, Ivan P. ; Grivin, Vjacheslav P. et al. / Primary photochemical processes for Pt(IV) diazido complexes prospectIVe in photodynamic therapy of tumors. In: Dalton Transactions. 2017 ; Vol. 46, No. 29. pp. 9440-9450.

BibTeX

@article{ce57eb75cd1144f68c1f9c2bd5f499d9,
title = "Primary photochemical processes for Pt(IV) diazido complexes prospectIVe in photodynamic therapy of tumors",
abstract = "Diazide diamino complexes of Pt(iv) are considered as prospective prodrugs in oxygen-free photodynamic therapy (PDT). Primary photophysical and photochemical processes for cis,trans,cis-[Pt(N3)2(OH)2(NH3)2] and trans,trans,trans-[Pt(N3)2(OH)2(NH3)2] complexes were studied by means of stationary photolysis, nanosecond laser flash photolysis and ultrafast kinetic spectroscopy. The process of photolysis is multistage. The first stage is the photosubstitution of an azide ligand to a water molecule. This process was shown to be a chain reaction involving redox stages. Pt(iv) and Pt(iii) intermediates responsible for the chain propagation were recorded using ultrafast kinetic spectroscopy and nanosecond laser flash photolysis. The mechanism of photosubstitution is proposed.",
keywords = "PLATINUM ANTICANCER COMPLEX, REDUCTIVE TRANS-ELIMINATION, AQUEOUS-SOLUTIONS, VISIBLE-LIGHT, IRCL62-COMPLEX, PTCL62-COMPLEX, RADICALS, PHOTOLYSIS, METHANOL, FE(III), Azides/chemistry, Neoplasms/drug therapy, Organoplatinum Compounds/chemistry, Photochemotherapy, Photolysis, Kinetics",
author = "Shushakov, {Anton A.} and Pozdnyakov, {Ivan P.} and Grivin, {Vjacheslav P.} and Plyusnin, {Victor F.} and Vasilchenko, {Danila B.} and Zadesenets, {Andrei V.} and Melnikov, {Alexei A.} and Chekalin, {Sergey V.} and Glebov, {Evgeni M.}",
note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",
year = "2017",
month = jul,
day = "25",
doi = "10.1039/c7dt01529a",
language = "English",
volume = "46",
pages = "9440--9450",
journal = "Dalton Transactions",
issn = "1477-9226",
publisher = "Royal Society of Chemistry",
number = "29",

}

RIS

TY - JOUR

T1 - Primary photochemical processes for Pt(IV) diazido complexes prospectIVe in photodynamic therapy of tumors

AU - Shushakov, Anton A.

AU - Pozdnyakov, Ivan P.

AU - Grivin, Vjacheslav P.

AU - Plyusnin, Victor F.

AU - Vasilchenko, Danila B.

AU - Zadesenets, Andrei V.

AU - Melnikov, Alexei A.

AU - Chekalin, Sergey V.

AU - Glebov, Evgeni M.

N1 - Publisher Copyright: © 2017 The Royal Society of Chemistry.

PY - 2017/7/25

Y1 - 2017/7/25

N2 - Diazide diamino complexes of Pt(iv) are considered as prospective prodrugs in oxygen-free photodynamic therapy (PDT). Primary photophysical and photochemical processes for cis,trans,cis-[Pt(N3)2(OH)2(NH3)2] and trans,trans,trans-[Pt(N3)2(OH)2(NH3)2] complexes were studied by means of stationary photolysis, nanosecond laser flash photolysis and ultrafast kinetic spectroscopy. The process of photolysis is multistage. The first stage is the photosubstitution of an azide ligand to a water molecule. This process was shown to be a chain reaction involving redox stages. Pt(iv) and Pt(iii) intermediates responsible for the chain propagation were recorded using ultrafast kinetic spectroscopy and nanosecond laser flash photolysis. The mechanism of photosubstitution is proposed.

AB - Diazide diamino complexes of Pt(iv) are considered as prospective prodrugs in oxygen-free photodynamic therapy (PDT). Primary photophysical and photochemical processes for cis,trans,cis-[Pt(N3)2(OH)2(NH3)2] and trans,trans,trans-[Pt(N3)2(OH)2(NH3)2] complexes were studied by means of stationary photolysis, nanosecond laser flash photolysis and ultrafast kinetic spectroscopy. The process of photolysis is multistage. The first stage is the photosubstitution of an azide ligand to a water molecule. This process was shown to be a chain reaction involving redox stages. Pt(iv) and Pt(iii) intermediates responsible for the chain propagation were recorded using ultrafast kinetic spectroscopy and nanosecond laser flash photolysis. The mechanism of photosubstitution is proposed.

KW - PLATINUM ANTICANCER COMPLEX

KW - REDUCTIVE TRANS-ELIMINATION

KW - AQUEOUS-SOLUTIONS

KW - VISIBLE-LIGHT

KW - IRCL62-COMPLEX

KW - PTCL62-COMPLEX

KW - RADICALS

KW - PHOTOLYSIS

KW - METHANOL

KW - FE(III)

KW - Azides/chemistry

KW - Neoplasms/drug therapy

KW - Organoplatinum Compounds/chemistry

KW - Photochemotherapy

KW - Photolysis

KW - Kinetics

UR - http://www.scopus.com/inward/record.url?scp=85026483119&partnerID=8YFLogxK

U2 - 10.1039/c7dt01529a

DO - 10.1039/c7dt01529a

M3 - Article

C2 - 28696474

AN - SCOPUS:85026483119

VL - 46

SP - 9440

EP - 9450

JO - Dalton Transactions

JF - Dalton Transactions

SN - 1477-9226

IS - 29

ER -

ID: 9023212