Potential regulatory SNPs in the ATXN7L3B and KRT15 genes are associated with gender-specific colorectal cancer risk

Standard

Potential regulatory SNPs in the ATXN7L3B and KRT15 genes are associated with gender-specific colorectal cancer risk. / Leberfarb, Elena Yu; Degtyareva, Arina O.; Brusentsov, Ilya I. et al.

In: Personalized Medicine, Vol. 17, No. 1, 01.2020, p. 43-54.

Research output: Contribution to journal › Article › peer-review

Harvard

Leberfarb, EY, Degtyareva, AO, Brusentsov, II, Maximov, VN, Voevoda, MI, Autenshlus, AI, Morozov, DV, Sokolov, AV & Merkulova, TI 2020, 'Potential regulatory SNPs in the ATXN7L3B and KRT15 genes are associated with gender-specific colorectal cancer risk', Personalized Medicine, vol. 17, no. 1, pp. 43-54. https://doi.org/10.2217/pme-2019-0059

APA

Leberfarb, E. Y., Degtyareva, A. O., Brusentsov, I. I., Maximov, V. N., Voevoda, M. I., Autenshlus, A. I., Morozov, D. V., Sokolov, A. V., & Merkulova, T. I. (2020). Potential regulatory SNPs in the ATXN7L3B and KRT15 genes are associated with gender-specific colorectal cancer risk. Personalized Medicine, 17(1), 43-54. https://doi.org/10.2217/pme-2019-0059

Vancouver

Leberfarb EY, Degtyareva AO, Brusentsov II, Maximov VN, Voevoda MI, Autenshlus AI et al. Potential regulatory SNPs in the ATXN7L3B and KRT15 genes are associated with gender-specific colorectal cancer risk. Personalized Medicine. 2020 Jan;17(1):43-54. doi: 10.2217/pme-2019-0059

Author

Leberfarb, Elena Yu ; Degtyareva, Arina O. ; Brusentsov, Ilya I. et al. / Potential regulatory SNPs in the ATXN7L3B and KRT15 genes are associated with gender-specific colorectal cancer risk. In: Personalized Medicine. 2020 ; Vol. 17, No. 1. pp. 43-54.

BibTeX

@article{100a246220e34c22b76d065dff264fb7,

title = "Potential regulatory SNPs in the ATXN7L3B and KRT15 genes are associated with gender-specific colorectal cancer risk",

abstract = "Aim: According to the current data, a major factor for phenotypic variation of complex traits and disease susceptibility is the cis-acting effects of noncoding variants on gene expression. Our purpose was to evaluate the association between colorectal cancer (CRC) and six single nucleotide polymorphisms identified using our original bioinformatics approach as regulatory and putatively related to CRC. Materials: One hundred and sixty CRC patients and 185 healthy controls have been genotyped for rs590352, rs2072580, rs78317230, rs3829202, rs11542583 and rs4796672. Results: Genotypes and alleles distributions of rs590352 of ATXN7L3B gene were significantly different between the male CRC subjects and controls. Significant correlation of genotype with CRC is observable for women only for the rs4796672 of KRT15 gene. Analysis of haplotypes reveals that rs2072580 of the ISCU and SART3 genes can be also associated with CRC. Conclusion: We have identified three SNPs associated with CRC risk and demonstrated a gender specificity of rs590352 and rs4796672.",

keywords = "association, ATXN7L3B, colorectal cancer, gender-specific, ISCU, KRT15, odds ratio, rSNPs, Russian residents of novosibirsk, SART3",

author = "Leberfarb, {Elena Yu} and Degtyareva, {Arina O.} and Brusentsov, {Ilya I.} and Maximov, {Vladimir N.} and Voevoda, {Mikhail I.} and Autenshlus, {Alexander I.} and Morozov, {Dmitriy V.} and Sokolov, {Andrey V.} and Merkulova, {Tatiana I.}",

year = "2020",

month = jan,

doi = "10.2217/pme-2019-0059",

language = "English",

volume = "17",

pages = "43--54",

journal = "Personalized Medicine",

issn = "1741-0541",

publisher = "Future Medicine Ltd.",

number = "1",

}

RIS

TY - JOUR

T1 - Potential regulatory SNPs in the ATXN7L3B and KRT15 genes are associated with gender-specific colorectal cancer risk

AU - Leberfarb, Elena Yu

AU - Degtyareva, Arina O.

AU - Brusentsov, Ilya I.

AU - Maximov, Vladimir N.

AU - Voevoda, Mikhail I.

AU - Autenshlus, Alexander I.

AU - Morozov, Dmitriy V.

AU - Sokolov, Andrey V.

AU - Merkulova, Tatiana I.

PY - 2020/1

Y1 - 2020/1

N2 - Aim: According to the current data, a major factor for phenotypic variation of complex traits and disease susceptibility is the cis-acting effects of noncoding variants on gene expression. Our purpose was to evaluate the association between colorectal cancer (CRC) and six single nucleotide polymorphisms identified using our original bioinformatics approach as regulatory and putatively related to CRC. Materials: One hundred and sixty CRC patients and 185 healthy controls have been genotyped for rs590352, rs2072580, rs78317230, rs3829202, rs11542583 and rs4796672. Results: Genotypes and alleles distributions of rs590352 of ATXN7L3B gene were significantly different between the male CRC subjects and controls. Significant correlation of genotype with CRC is observable for women only for the rs4796672 of KRT15 gene. Analysis of haplotypes reveals that rs2072580 of the ISCU and SART3 genes can be also associated with CRC. Conclusion: We have identified three SNPs associated with CRC risk and demonstrated a gender specificity of rs590352 and rs4796672.

AB - Aim: According to the current data, a major factor for phenotypic variation of complex traits and disease susceptibility is the cis-acting effects of noncoding variants on gene expression. Our purpose was to evaluate the association between colorectal cancer (CRC) and six single nucleotide polymorphisms identified using our original bioinformatics approach as regulatory and putatively related to CRC. Materials: One hundred and sixty CRC patients and 185 healthy controls have been genotyped for rs590352, rs2072580, rs78317230, rs3829202, rs11542583 and rs4796672. Results: Genotypes and alleles distributions of rs590352 of ATXN7L3B gene were significantly different between the male CRC subjects and controls. Significant correlation of genotype with CRC is observable for women only for the rs4796672 of KRT15 gene. Analysis of haplotypes reveals that rs2072580 of the ISCU and SART3 genes can be also associated with CRC. Conclusion: We have identified three SNPs associated with CRC risk and demonstrated a gender specificity of rs590352 and rs4796672.

KW - association

KW - ATXN7L3B

KW - colorectal cancer

KW - gender-specific

KW - ISCU

KW - KRT15

KW - odds ratio

KW - rSNPs

KW - Russian residents of novosibirsk

KW - SART3

UR - http://www.scopus.com/inward/record.url?scp=85076876563&partnerID=8YFLogxK

U2 - 10.2217/pme-2019-0059

DO - 10.2217/pme-2019-0059

M3 - Article

C2 - 31797724

AN - SCOPUS:85076876563

VL - 17

SP - 43

EP - 54

JO - Personalized Medicine

JF - Personalized Medicine

SN - 1741-0541

IS - 1

ER -

ID: 22996798