Standard

Poly(ADP-ribose) in Condensates: The PARtnership of Phase Separation and Site-Specific Interactions. / Alemasova, Elizaveta E.; Lavrik, Olga I.

In: International Journal of Molecular Sciences, Vol. 23, No. 22, 14075, 11.2022.

Research output: Contribution to journal › Review article › peer-review

Harvard

Alemasova, EE & Lavrik, OI 2022, 'Poly(ADP-ribose) in Condensates: The PARtnership of Phase Separation and Site-Specific Interactions', International Journal of Molecular Sciences, vol. 23, no. 22, 14075. https://doi.org/10.3390/ijms232214075

APA

Alemasova, E. E., & Lavrik, O. I. (2022). Poly(ADP-ribose) in Condensates: The PARtnership of Phase Separation and Site-Specific Interactions. International Journal of Molecular Sciences, 23(22), [14075]. https://doi.org/10.3390/ijms232214075

Vancouver

Alemasova EE, Lavrik OI. Poly(ADP-ribose) in Condensates: The PARtnership of Phase Separation and Site-Specific Interactions. International Journal of Molecular Sciences. 2022 Nov;23(22):14075. doi: 10.3390/ijms232214075

Author

Alemasova, Elizaveta E. ; Lavrik, Olga I. / Poly(ADP-ribose) in Condensates: The PARtnership of Phase Separation and Site-Specific Interactions. In: International Journal of Molecular Sciences. 2022 ; Vol. 23, No. 22.

BibTeX

@article{5ce251e7c274453ab398661c8c1ea996,
title = "Poly(ADP-ribose) in Condensates: The PARtnership of Phase Separation and Site-Specific Interactions",
abstract = "Biomolecular condensates are nonmembrane cellular compartments whose formation in many cases involves phase separation (PS). Despite much research interest in this mechanism of macromolecular self-organization, the concept of PS as applied to a live cell faces certain challenges. In this review, we discuss a basic model of PS and the role of site-specific interactions and percolation in cellular PS-related events. Using a multivalent poly(ADP-ribose) molecule as an example, which has high PS-driving potential due to its structural features, we consider how site-specific interactions and network formation are involved in the formation of phase-separated cellular condensates.",
keywords = "condensate, liquid–liquid phase separation (LLPS), PARP, poly(ADP-ribose) (PAR), Poly Adenosine Diphosphate Ribose, Macromolecular Substances",
author = "Alemasova, {Elizaveta E.} and Lavrik, {Olga I.}",
note = "Funding Information: We express our gratitude to Nikolay Shevchuk for language editing. Physics of LLPS is discussed within the framework of project number 121031300041-4 by the Ministry of Higher Education and Science of Russian Federation. The concept of restricted PS and PAR PS-driving potential are discussed in the frame of project No. 21-64-00017 from the Russian Science Foundation. The concept of percolation-coupled PS as well as PAR PS in cells are discussed within the framework of project No. 22-14-00112 from the Russian Science Foundation. Publisher Copyright: {\textcopyright} 2022 by the authors.",
year = "2022",
month = nov,
doi = "10.3390/ijms232214075",
language = "English",
volume = "23",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "22",

}

RIS

TY - JOUR

T1 - Poly(ADP-ribose) in Condensates: The PARtnership of Phase Separation and Site-Specific Interactions

AU - Alemasova, Elizaveta E.

AU - Lavrik, Olga I.

N1 - Funding Information: We express our gratitude to Nikolay Shevchuk for language editing. Physics of LLPS is discussed within the framework of project number 121031300041-4 by the Ministry of Higher Education and Science of Russian Federation. The concept of restricted PS and PAR PS-driving potential are discussed in the frame of project No. 21-64-00017 from the Russian Science Foundation. The concept of percolation-coupled PS as well as PAR PS in cells are discussed within the framework of project No. 22-14-00112 from the Russian Science Foundation. Publisher Copyright: © 2022 by the authors.

PY - 2022/11

Y1 - 2022/11

N2 - Biomolecular condensates are nonmembrane cellular compartments whose formation in many cases involves phase separation (PS). Despite much research interest in this mechanism of macromolecular self-organization, the concept of PS as applied to a live cell faces certain challenges. In this review, we discuss a basic model of PS and the role of site-specific interactions and percolation in cellular PS-related events. Using a multivalent poly(ADP-ribose) molecule as an example, which has high PS-driving potential due to its structural features, we consider how site-specific interactions and network formation are involved in the formation of phase-separated cellular condensates.

AB - Biomolecular condensates are nonmembrane cellular compartments whose formation in many cases involves phase separation (PS). Despite much research interest in this mechanism of macromolecular self-organization, the concept of PS as applied to a live cell faces certain challenges. In this review, we discuss a basic model of PS and the role of site-specific interactions and percolation in cellular PS-related events. Using a multivalent poly(ADP-ribose) molecule as an example, which has high PS-driving potential due to its structural features, we consider how site-specific interactions and network formation are involved in the formation of phase-separated cellular condensates.

KW - condensate

KW - liquid–liquid phase separation (LLPS)

KW - PARP

KW - poly(ADP-ribose) (PAR)

KW - Poly Adenosine Diphosphate Ribose

KW - Macromolecular Substances

UR - http://www.scopus.com/inward/record.url?scp=85142833916&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/1dbf2e53-631a-3602-8758-eadd0e7d947c/

U2 - 10.3390/ijms232214075

DO - 10.3390/ijms232214075

M3 - Review article

C2 - 36430551

AN - SCOPUS:85142833916

VL - 23

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 22

M1 - 14075

ER -

ID: 40099720