Polarization of low-γ nuclei by transferring spin order of parahydrogen at high magnetic fields

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Polarization of low-γ nuclei by transferring spin order of parahydrogen at high magnetic fields. / Kozinenko, Vitaly P.; Kiryutin, Alexey S.; Yurkovskaya, Alexandra V. et al.

In: Journal of Magnetic Resonance, Vol. 309, 106594, 01.12.2019.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{0065d2b5be354fef8422fe85b8d91a41,

title = "Polarization of low-γ nuclei by transferring spin order of parahydrogen at high magnetic fields",

abstract = "In this work, we optimize the performance of a previously proposed method for transferring parahydrogen induced polarization to “insensitive” spin-1/2 NMR (Nuclear Magnetic Resonance) nuclei, which have low gyromagnetic ratio and low natural abundance. By optimizing the reaction conditions and pressure of the parahydrogen gas and using adiabatically switched radiofrequency fields we achieve high polarization transfer efficiency and report carbon spin polarization of dimethyl acetylene dicarboxylate reaching 35%, which corresponds to 13C NMR signal enhancements of about 43,000 at 9.4 Tesla. Such polarization levels allow one to work with mM concentrations at natural carbon abundance and to detect 13C NMR signal in single scan. In combination with a pseudo phase cycle, the polarization transfer method used here also enables efficient suppression of unwanted background signals.",

keywords = "PARA-HYDROGEN, HYPERPOLARIZATION, NMR, RESONANCE, C-13, ENHANCE, STATES, LEVEL, MRI",

author = "Kozinenko, {Vitaly P.} and Kiryutin, {Alexey S.} and Yurkovskaya, {Alexandra V.} and Ivanov, {Konstantin L.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = dec,

day = "1",

doi = "10.1016/j.jmr.2019.106594",

language = "English",

volume = "309",

journal = "Journal of Magnetic Resonance",

issn = "1090-7807",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Polarization of low-γ nuclei by transferring spin order of parahydrogen at high magnetic fields

AU - Kozinenko, Vitaly P.

AU - Kiryutin, Alexey S.

AU - Yurkovskaya, Alexandra V.

AU - Ivanov, Konstantin L.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - In this work, we optimize the performance of a previously proposed method for transferring parahydrogen induced polarization to “insensitive” spin-1/2 NMR (Nuclear Magnetic Resonance) nuclei, which have low gyromagnetic ratio and low natural abundance. By optimizing the reaction conditions and pressure of the parahydrogen gas and using adiabatically switched radiofrequency fields we achieve high polarization transfer efficiency and report carbon spin polarization of dimethyl acetylene dicarboxylate reaching 35%, which corresponds to 13C NMR signal enhancements of about 43,000 at 9.4 Tesla. Such polarization levels allow one to work with mM concentrations at natural carbon abundance and to detect 13C NMR signal in single scan. In combination with a pseudo phase cycle, the polarization transfer method used here also enables efficient suppression of unwanted background signals.

AB - In this work, we optimize the performance of a previously proposed method for transferring parahydrogen induced polarization to “insensitive” spin-1/2 NMR (Nuclear Magnetic Resonance) nuclei, which have low gyromagnetic ratio and low natural abundance. By optimizing the reaction conditions and pressure of the parahydrogen gas and using adiabatically switched radiofrequency fields we achieve high polarization transfer efficiency and report carbon spin polarization of dimethyl acetylene dicarboxylate reaching 35%, which corresponds to 13C NMR signal enhancements of about 43,000 at 9.4 Tesla. Such polarization levels allow one to work with mM concentrations at natural carbon abundance and to detect 13C NMR signal in single scan. In combination with a pseudo phase cycle, the polarization transfer method used here also enables efficient suppression of unwanted background signals.

KW - PARA-HYDROGEN

KW - HYPERPOLARIZATION

KW - NMR

KW - RESONANCE

KW - C-13

KW - ENHANCE

KW - STATES

KW - LEVEL

KW - MRI

UR - http://www.scopus.com/inward/record.url?scp=85072640543&partnerID=8YFLogxK

U2 - 10.1016/j.jmr.2019.106594

DO - 10.1016/j.jmr.2019.106594

M3 - Article

C2 - 31569052

AN - SCOPUS:85072640543

VL - 309

JO - Journal of Magnetic Resonance

JF - Journal of Magnetic Resonance

SN - 1090-7807

M1 - 106594

ER -

ID: 21609143