Pilot multi-site quality assurance study of batch-mode clinical-scale automated xenon-129 hyperpolarizers

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Pilot multi-site quality assurance study of batch-mode clinical-scale automated xenon-129 hyperpolarizers. / Birchall, Jonathan R.; Irwin, Robert K.; Nikolaou, Panayiotis et al.

In: Journal of Magnetic Resonance, Vol. 316, 106755, 07.2020, p. 106755.

Research output: Contribution to journal › Article › peer-review

Harvard

Birchall, JR, Irwin, RK, Nikolaou, P, Pokochueva, EV, Kovtunov, KV, Koptyug, IV, Barlow, MJ, Goodson, BM & Chekmenev, EY 2020, 'Pilot multi-site quality assurance study of batch-mode clinical-scale automated xenon-129 hyperpolarizers', Journal of Magnetic Resonance, vol. 316, 106755, pp. 106755. https://doi.org/10.1016/j.jmr.2020.106755

APA

Birchall, J. R., Irwin, R. K., Nikolaou, P., Pokochueva, E. V., Kovtunov, K. V., Koptyug, I. V., Barlow, M. J., Goodson, B. M., & Chekmenev, E. Y. (2020). Pilot multi-site quality assurance study of batch-mode clinical-scale automated xenon-129 hyperpolarizers. Journal of Magnetic Resonance, 316, 106755. [106755]. https://doi.org/10.1016/j.jmr.2020.106755

Vancouver

Birchall JR, Irwin RK, Nikolaou P, Pokochueva EV, Kovtunov KV, Koptyug IV et al. Pilot multi-site quality assurance study of batch-mode clinical-scale automated xenon-129 hyperpolarizers. Journal of Magnetic Resonance. 2020 Jul;316:106755. 106755. Epub 2020 May 29. doi: 10.1016/j.jmr.2020.106755

Author

Birchall, Jonathan R. ; Irwin, Robert K. ; Nikolaou, Panayiotis et al. / Pilot multi-site quality assurance study of batch-mode clinical-scale automated xenon-129 hyperpolarizers. In: Journal of Magnetic Resonance. 2020 ; Vol. 316. pp. 106755.

BibTeX

@article{75f900b5a7dc43a68e861cbcc1d059e3,

title = "Pilot multi-site quality assurance study of batch-mode clinical-scale automated xenon-129 hyperpolarizers",

abstract = "We present a pilot quality assurance (QA) study of spin-exchange optical pumping (SEOP) performed on two nearly identical second-generation (GEN-2) automated batch-mode clinical-scale 129Xe hyperpolarizers, each utilizing a convective forced air oven, high-power (~170 W) continuous pump laser irradiation, and xenon-rich gas mixtures (~1.30 atm partial pressure). In one study, the repeatability of SEOP in a 1000 Torr Xe/900 Torr N2/100 Torr 4He (2000 Torr total pressure) gas mixture is evaluated over the course of ~700 gas loading cycles, with negligible decrease in performance during the first ~200 cycles, and with high 129Xe polarization levels (avg. %PXe = 71.7% with standard deviation σPXe = 1.5%), build-up rates (avg. γSEOP = 0.019 min−1 with standard deviation σγ = 0.003 min−1) and polarization lifetimes (avg. T1 = 90.5 min with standard deviation σT = 10.3 min) reported at moderate oven temperature of ~70 °C. Although the SEOP cell in this study exhibited a detectable performance decrease after 400 cycles, the cell continued to produce potentially useable HP 129Xe with %PXe = 42.3 ± 0.6% even after nearly 700 refill cycles. The possibility of “regenerating” “dormant” (i.e., not used for an extended period of time) SEOP cells using repeated temperature cycling methods to recover %PXe is also demonstrated. The quality and consistency of results show significant promise for translation to clinical-scale production of hyperpolarized 129Xe contrast agents for imaging and bio-sensing applications.",

keywords = "Automation, Hyperpolarization, Hyperpolarizer, Quality assurance, SEOP, Xenon, XENON POLARIZATION, MRI, LASER-DIODE ARRAYS, SPIN-POLARIZED XE-129, NMR, SPECTROSCOPY, MAGNETIC-RESONANCE, GAS, PERFUSION, EXCHANGE",

author = "Birchall, {Jonathan R.} and Irwin, {Robert K.} and Panayiotis Nikolaou and Pokochueva, {Ekaterina V.} and Kovtunov, {Kirill V.} and Koptyug, {Igor V.} and Barlow, {Michael J.} and Goodson, {Boyd M.} and Chekmenev, {Eduard Y.}",

year = "2020",

month = jul,

doi = "10.1016/j.jmr.2020.106755",

language = "English",

volume = "316",

pages = "106755",

journal = "Journal of Magnetic Resonance",

issn = "1090-7807",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Pilot multi-site quality assurance study of batch-mode clinical-scale automated xenon-129 hyperpolarizers

AU - Birchall, Jonathan R.

AU - Irwin, Robert K.

AU - Nikolaou, Panayiotis

AU - Pokochueva, Ekaterina V.

AU - Kovtunov, Kirill V.

AU - Koptyug, Igor V.

AU - Barlow, Michael J.

AU - Goodson, Boyd M.

AU - Chekmenev, Eduard Y.

PY - 2020/7

Y1 - 2020/7

N2 - We present a pilot quality assurance (QA) study of spin-exchange optical pumping (SEOP) performed on two nearly identical second-generation (GEN-2) automated batch-mode clinical-scale 129Xe hyperpolarizers, each utilizing a convective forced air oven, high-power (~170 W) continuous pump laser irradiation, and xenon-rich gas mixtures (~1.30 atm partial pressure). In one study, the repeatability of SEOP in a 1000 Torr Xe/900 Torr N2/100 Torr 4He (2000 Torr total pressure) gas mixture is evaluated over the course of ~700 gas loading cycles, with negligible decrease in performance during the first ~200 cycles, and with high 129Xe polarization levels (avg. %PXe = 71.7% with standard deviation σPXe = 1.5%), build-up rates (avg. γSEOP = 0.019 min−1 with standard deviation σγ = 0.003 min−1) and polarization lifetimes (avg. T1 = 90.5 min with standard deviation σT = 10.3 min) reported at moderate oven temperature of ~70 °C. Although the SEOP cell in this study exhibited a detectable performance decrease after 400 cycles, the cell continued to produce potentially useable HP 129Xe with %PXe = 42.3 ± 0.6% even after nearly 700 refill cycles. The possibility of “regenerating” “dormant” (i.e., not used for an extended period of time) SEOP cells using repeated temperature cycling methods to recover %PXe is also demonstrated. The quality and consistency of results show significant promise for translation to clinical-scale production of hyperpolarized 129Xe contrast agents for imaging and bio-sensing applications.

AB - We present a pilot quality assurance (QA) study of spin-exchange optical pumping (SEOP) performed on two nearly identical second-generation (GEN-2) automated batch-mode clinical-scale 129Xe hyperpolarizers, each utilizing a convective forced air oven, high-power (~170 W) continuous pump laser irradiation, and xenon-rich gas mixtures (~1.30 atm partial pressure). In one study, the repeatability of SEOP in a 1000 Torr Xe/900 Torr N2/100 Torr 4He (2000 Torr total pressure) gas mixture is evaluated over the course of ~700 gas loading cycles, with negligible decrease in performance during the first ~200 cycles, and with high 129Xe polarization levels (avg. %PXe = 71.7% with standard deviation σPXe = 1.5%), build-up rates (avg. γSEOP = 0.019 min−1 with standard deviation σγ = 0.003 min−1) and polarization lifetimes (avg. T1 = 90.5 min with standard deviation σT = 10.3 min) reported at moderate oven temperature of ~70 °C. Although the SEOP cell in this study exhibited a detectable performance decrease after 400 cycles, the cell continued to produce potentially useable HP 129Xe with %PXe = 42.3 ± 0.6% even after nearly 700 refill cycles. The possibility of “regenerating” “dormant” (i.e., not used for an extended period of time) SEOP cells using repeated temperature cycling methods to recover %PXe is also demonstrated. The quality and consistency of results show significant promise for translation to clinical-scale production of hyperpolarized 129Xe contrast agents for imaging and bio-sensing applications.

KW - Automation

KW - Hyperpolarization

KW - Hyperpolarizer

KW - Quality assurance

KW - SEOP

KW - Xenon

KW - XENON POLARIZATION

KW - MRI

KW - LASER-DIODE ARRAYS

KW - SPIN-POLARIZED XE-129

KW - NMR

KW - SPECTROSCOPY

KW - MAGNETIC-RESONANCE

KW - GAS

KW - PERFUSION

KW - EXCHANGE

UR - http://www.scopus.com/inward/record.url?scp=85085987787&partnerID=8YFLogxK

U2 - 10.1016/j.jmr.2020.106755

DO - 10.1016/j.jmr.2020.106755

M3 - Article

C2 - 32512397

AN - SCOPUS:85085987787

VL - 316

SP - 106755

JO - Journal of Magnetic Resonance

JF - Journal of Magnetic Resonance

SN - 1090-7807

M1 - 106755

ER -

ID: 24518675