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Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery. / Apartsin, Evgeny; Knauer, Nadezhda; Arkhipova, Valeria et al.

In: Nanomaterials, Vol. 10, No. 10, 1899, 01.10.2020, p. 1-15.

Research output: Contribution to journal › Article › peer-review

Harvard

Apartsin, E, Knauer, N, Arkhipova, V, Pashkina, E, Aktanova, A, Poletaeva, J, Sánchez-Nieves, J, de la Mata, FJ & Gómez, R 2020, 'Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery', Nanomaterials, vol. 10, no. 10, 1899, pp. 1-15. https://doi.org/10.3390/nano10101899

APA

Apartsin, E., Knauer, N., Arkhipova, V., Pashkina, E., Aktanova, A., Poletaeva, J., Sánchez-Nieves, J., de la Mata, F. J., & Gómez, R. (2020). Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery. Nanomaterials, 10(10), 1-15. [1899]. https://doi.org/10.3390/nano10101899

Vancouver

Apartsin E, Knauer N, Arkhipova V, Pashkina E, Aktanova A, Poletaeva J et al. Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery. Nanomaterials. 2020 Oct 1;10(10):1-15. 1899. doi: 10.3390/nano10101899

Author

Apartsin, Evgeny ; Knauer, Nadezhda ; Arkhipova, Valeria et al. / Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery. In: Nanomaterials. 2020 ; Vol. 10, No. 10. pp. 1-15.

BibTeX

@article{f4a81a0e1d6543648da74c125f72780a,
title = "Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery",
abstract = "Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.",
keywords = "Amphiphile, Carbosilane, Dendron, Doxorubicin, Leukaemia, Methotrexate, PH-sensitive, Self-assembly, Triazine, Vesicles",
author = "Evgeny Apartsin and Nadezhda Knauer and Valeria Arkhipova and Ekaterina Pashkina and Alina Aktanova and Julia Poletaeva and Javier S{\'a}nchez-Nieves and {de la Mata}, {Francisco Javier} and Rafael G{\'o}mez",
note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2020",
month = oct,
day = "1",
doi = "10.3390/nano10101899",
language = "English",
volume = "10",
pages = "1--15",
journal = "Nanomaterials",
issn = "2079-4991",
publisher = "MDPI AG",
number = "10",

}

RIS

TY - JOUR

T1 - Ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery

AU - Apartsin, Evgeny

AU - Knauer, Nadezhda

AU - Arkhipova, Valeria

AU - Pashkina, Ekaterina

AU - Aktanova, Alina

AU - Poletaeva, Julia

AU - Sánchez-Nieves, Javier

AU - de la Mata, Francisco Javier

AU - Gómez, Rafael

N1 - Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.

AB - Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.

KW - Amphiphile

KW - Carbosilane

KW - Dendron

KW - Doxorubicin

KW - Leukaemia

KW - Methotrexate

KW - PH-sensitive

KW - Self-assembly

KW - Triazine

KW - Vesicles

UR - http://www.scopus.com/inward/record.url?scp=85091386481&partnerID=8YFLogxK

U2 - 10.3390/nano10101899

DO - 10.3390/nano10101899

M3 - Article

C2 - 32977594

AN - SCOPUS:85091386481

VL - 10

SP - 1

EP - 15

JO - Nanomaterials

JF - Nanomaterials

SN - 2079-4991

IS - 10

M1 - 1899

ER -

ID: 25312432