Photophysical properties of benzo[i]dipyrido[3,2-a:2′,3′-c] phenazine (dppn) – A prospective ligand for light-activated anticancer complexes

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Photophysical properties of benzo[i]dipyrido[3,2-a:2′,3′-c] phenazine (dppn) – A prospective ligand for light-activated anticancer complexes. / Meshcheryakova, V. A.; Grivin, V. P.; Mikheylis, A. V. et al.

In: Journal of Luminescence, Vol. 275, 120804, 11.2024.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{97d78f89cef147a797bbad0b96f0c5ce,

title = "Photophysical properties of benzo[i]dipyrido[3,2-a:2′,3′-c] phenazine (dppn) – A prospective ligand for light-activated anticancer complexes",

abstract = "Benzo[i]dipyrido[3,2-a:2′,3′c]phenazine (dppn) is a prospective ligand for constructing light-activated anticancer complexes of platinum metals. In spite of practical importance, only scarce information on the dppn photophysics and photochemistry was found in the literature. In this work photophysical properties of dppn in acetonitrile solutions were studied by means of stationary and laser flash photolysis, time-resolved luminescence, time-resolved singlet oxygen detection and ultrafast TA spectroscopy. Quantitative characteristics of luminescence (quantum yield 0.26, lifetime 52 ns in deaerated solutions) were measured. Triplet state of the initial compound 3dppn* is formed with the quantum yield estimated as 0.4 from the singlet oxygen production; the main channels of 3dppn* are quenching by dissolved oxygen and self-quenching by the ground state of dppn. Combining the data of ultrafast TA absorption and time-resolved luminescence, we detected the formation of “dark” (not emissive) excited state of dppn with the decay time ca. 150 ps. Two hypotheses on the nature of the dark state were put forward.",

author = "Meshcheryakova, {V. A.} and Grivin, {V. P.} and Mikheylis, {A. V.} and Tsentalovich, {Yu P.} and Kokorenko, {A. A.} and Pozdnyakov, {I. P.} and Ershov, {K. S.} and Baklanov, {A. V.} and Zazulya, {A. E.} and Vasilchenko, {D. B.} and Melnikov, {A. A.} and Chekalin, {S. V.} and Glebov, {E. M.}",

note = "The financial support of the Russian Science Foundation (Grant No 23-13-00226) is gratefully acknowledged.",

year = "2024",

month = nov,

doi = "10.1016/j.jlumin.2024.120804",

language = "English",

volume = "275",

journal = "Journal of Luminescence",

issn = "0022-2313",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Photophysical properties of benzo[i]dipyrido[3,2-a:2′,3′-c] phenazine (dppn) – A prospective ligand for light-activated anticancer complexes

AU - Meshcheryakova, V. A.

AU - Grivin, V. P.

AU - Mikheylis, A. V.

AU - Tsentalovich, Yu P.

AU - Kokorenko, A. A.

AU - Pozdnyakov, I. P.

AU - Ershov, K. S.

AU - Baklanov, A. V.

AU - Zazulya, A. E.

AU - Vasilchenko, D. B.

AU - Melnikov, A. A.

AU - Chekalin, S. V.

AU - Glebov, E. M.

N1 - The financial support of the Russian Science Foundation (Grant No 23-13-00226) is gratefully acknowledged.

PY - 2024/11

Y1 - 2024/11

N2 - Benzo[i]dipyrido[3,2-a:2′,3′c]phenazine (dppn) is a prospective ligand for constructing light-activated anticancer complexes of platinum metals. In spite of practical importance, only scarce information on the dppn photophysics and photochemistry was found in the literature. In this work photophysical properties of dppn in acetonitrile solutions were studied by means of stationary and laser flash photolysis, time-resolved luminescence, time-resolved singlet oxygen detection and ultrafast TA spectroscopy. Quantitative characteristics of luminescence (quantum yield 0.26, lifetime 52 ns in deaerated solutions) were measured. Triplet state of the initial compound 3dppn* is formed with the quantum yield estimated as 0.4 from the singlet oxygen production; the main channels of 3dppn* are quenching by dissolved oxygen and self-quenching by the ground state of dppn. Combining the data of ultrafast TA absorption and time-resolved luminescence, we detected the formation of “dark” (not emissive) excited state of dppn with the decay time ca. 150 ps. Two hypotheses on the nature of the dark state were put forward.

AB - Benzo[i]dipyrido[3,2-a:2′,3′c]phenazine (dppn) is a prospective ligand for constructing light-activated anticancer complexes of platinum metals. In spite of practical importance, only scarce information on the dppn photophysics and photochemistry was found in the literature. In this work photophysical properties of dppn in acetonitrile solutions were studied by means of stationary and laser flash photolysis, time-resolved luminescence, time-resolved singlet oxygen detection and ultrafast TA spectroscopy. Quantitative characteristics of luminescence (quantum yield 0.26, lifetime 52 ns in deaerated solutions) were measured. Triplet state of the initial compound 3dppn* is formed with the quantum yield estimated as 0.4 from the singlet oxygen production; the main channels of 3dppn* are quenching by dissolved oxygen and self-quenching by the ground state of dppn. Combining the data of ultrafast TA absorption and time-resolved luminescence, we detected the formation of “dark” (not emissive) excited state of dppn with the decay time ca. 150 ps. Two hypotheses on the nature of the dark state were put forward.

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85199186000&origin=inward&txGid=c5cb9ad096fba77dabd7980a5407369a

UR - https://www.mendeley.com/catalogue/504e7600-1598-38f3-ad15-1ec97d698c43/

U2 - 10.1016/j.jlumin.2024.120804

DO - 10.1016/j.jlumin.2024.120804

M3 - Article

VL - 275

JO - Journal of Luminescence

JF - Journal of Luminescence

SN - 0022-2313

M1 - 120804

ER -

ID: 60390596