Research output: Contribution to journal › Article › peer-review
Photochemistry of cis,trans-[Pt(en)(I)2(OH)2] complex in aqueous solutions. / Glebov, Evgeni M.; Pozdnyakov, Ivan P.; Vasilchenko, Danila B. et al.
In: Journal of Photochemistry and Photobiology A: Chemistry, Vol. 354, 01.03.2018, p. 78-85.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Photochemistry of cis,trans-[Pt(en)(I)2(OH)2] complex in aqueous solutions
AU - Glebov, Evgeni M.
AU - Pozdnyakov, Ivan P.
AU - Vasilchenko, Danila B.
AU - Zadesenets, Andrey V.
AU - Melnikov, Alexey A.
AU - Magin, Ilya M.
AU - Grivin, Vjacheslav P.
AU - Chekalin, Sergey V.
AU - Plyusnin, Victor F.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Diiodido Pt(IV) complexes (earlier tested as prodrugs in photodynamic therapy) could be considered as model mixed-ligand platinum complexes. In this work, photochemistry of cis,trans-[PtIV(en)(I)2(OH)2] complex (1) in aqueous solutions was examined in time interval from hundreds of femtoseconds to hours. UV and NMR spectroscopy, nanosecond laser flash photolysis and ultrafast spectroscopy were applied to study the primary photochemical processes of 1. As it was shown earlier, photolysis of the complex is multistage. On the first stage, mer-[PtIV(en)(I)(OH)3] complex is formed with the quantum yield of 0.06 (irradiation at 282nm). Further ligand exchange and photoreduction occur with much lower quantum yield. The characteristic lifetime of ligand exchange is about 90ps. The spectrum of the key intermediate (KI) was recorded in the picosecond time domain. Depending on the attribution of the KI, two tentative schemes of the primary photophysical and photochemical processes are proposed.
AB - Diiodido Pt(IV) complexes (earlier tested as prodrugs in photodynamic therapy) could be considered as model mixed-ligand platinum complexes. In this work, photochemistry of cis,trans-[PtIV(en)(I)2(OH)2] complex (1) in aqueous solutions was examined in time interval from hundreds of femtoseconds to hours. UV and NMR spectroscopy, nanosecond laser flash photolysis and ultrafast spectroscopy were applied to study the primary photochemical processes of 1. As it was shown earlier, photolysis of the complex is multistage. On the first stage, mer-[PtIV(en)(I)(OH)3] complex is formed with the quantum yield of 0.06 (irradiation at 282nm). Further ligand exchange and photoreduction occur with much lower quantum yield. The characteristic lifetime of ligand exchange is about 90ps. The spectrum of the key intermediate (KI) was recorded in the picosecond time domain. Depending on the attribution of the KI, two tentative schemes of the primary photophysical and photochemical processes are proposed.
KW - cis,trans-[Pt(en)(I)(OH)]
KW - Diiodido Pt(IV) complexes
KW - Laser flash photolysis
KW - Photoexchange
KW - Photoreduction
KW - Ultrafast spectroscopy
KW - DNA-ADDUCTS
KW - EXCITATION
KW - PHOTODYNAMIC THERAPY
KW - TUMOR-CELLS
KW - VISIBLE-LIGHT
KW - REPLICATION
KW - INHIBITION
KW - ANTICANCER COMPLEXES
KW - PLATINUM(IV)
KW - cis,trans-[Pt-IV(en)(I)(2)(OH)(2)]
KW - BINDING
UR - http://www.scopus.com/inward/record.url?scp=85021825966&partnerID=8YFLogxK
U2 - 10.1016/j.jphotochem.2017.06.036
DO - 10.1016/j.jphotochem.2017.06.036
M3 - Article
AN - SCOPUS:85021825966
VL - 354
SP - 78
EP - 85
JO - Journal of Photochemistry and Photobiology A: Chemistry
JF - Journal of Photochemistry and Photobiology A: Chemistry
SN - 1010-6030
ER -
ID: 9023441