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PHIP hyperpolarized [1-13C]pyruvate and [1-13C]acetate esters via PH-INEPT polarization transfer monitored by 13C NMR and MRI. / Svyatova, Alexandra; Kozinenko, Vitaly P.; Chukanov, Nikita V. et al.

In: Scientific Reports, Vol. 11, No. 1, 5646, 03.2021.

Research output: Contribution to journal › Article › peer-review

Harvard

Svyatova, A, Kozinenko, VP, Chukanov, NV, Burueva, DB, Chekmenev, EY, Chen, YW, Hwang, DW, Kovtunov, KV & Koptyug, IV 2021, 'PHIP hyperpolarized [1-13C]pyruvate and [1-13C]acetate esters via PH-INEPT polarization transfer monitored by 13C NMR and MRI', Scientific Reports, vol. 11, no. 1, 5646. https://doi.org/10.1038/s41598-021-85136-2

APA

Svyatova, A., Kozinenko, V. P., Chukanov, N. V., Burueva, D. B., Chekmenev, E. Y., Chen, Y. W., Hwang, D. W., Kovtunov, K. V., & Koptyug, I. V. (2021). PHIP hyperpolarized [1-13C]pyruvate and [1-13C]acetate esters via PH-INEPT polarization transfer monitored by 13C NMR and MRI. Scientific Reports, 11(1), [5646]. https://doi.org/10.1038/s41598-021-85136-2

Vancouver

Svyatova A, Kozinenko VP, Chukanov NV, Burueva DB, Chekmenev EY, Chen YW et al. PHIP hyperpolarized [1-13C]pyruvate and [1-13C]acetate esters via PH-INEPT polarization transfer monitored by 13C NMR and MRI. Scientific Reports. 2021 Mar;11(1):5646. doi: 10.1038/s41598-021-85136-2

Author

Svyatova, Alexandra ; Kozinenko, Vitaly P. ; Chukanov, Nikita V. et al. / PHIP hyperpolarized [1-13C]pyruvate and [1-13C]acetate esters via PH-INEPT polarization transfer monitored by 13C NMR and MRI. In: Scientific Reports. 2021 ; Vol. 11, No. 1.

BibTeX

@article{ae8a7726a73f40ecb0442b25c3616c60,
title = "PHIP hyperpolarized [1-13C]pyruvate and [1-13C]acetate esters via PH-INEPT polarization transfer monitored by 13C NMR and MRI",
abstract = "Parahydrogen-induced polarization of 13C nuclei by side-arm hydrogenation (PHIP-SAH) for [1-13C]acetate and [1-13C]pyruvate esters with application of PH-INEPT-type pulse sequences for 1H to 13C polarization transfer is reported, and its efficiency is compared with that of polarization transfer based on magnetic field cycling (MFC). The pulse-sequence transfer approach may have its merits in some applications because the entire hyperpolarization procedure is implemented directly in an NMR or MRI instrument, whereas MFC requires a controlled field variation at low magnetic fields. Optimization of the PH-INEPT-type transfer sequences resulted in 13C polarization values of 0.66 ± 0.04% and 0.19 ± 0.02% for allyl [1-13C]pyruvate and ethyl [1-13C]acetate, respectively, which is lower than the corresponding polarization levels obtained with MFC for 1H to 13C polarization transfer (3.95 ± 0.05% and 0.65 ± 0.05% for allyl [1-13C]pyruvate and ethyl [1-13C]acetate, respectively). Nevertheless, a significant 13C NMR signal enhancement with respect to thermal polarization allowed us to perform 13C MR imaging of both biologically relevant hyperpolarized molecules which can be used to produce useful contrast agents for the in vivo imaging applications.",
author = "Alexandra Svyatova and Kozinenko, {Vitaly P.} and Chukanov, {Nikita V.} and Burueva, {Dudari B.} and Chekmenev, {Eduard Y.} and Chen, {Yu Wen} and Hwang, {Dennis W.} and Kovtunov, {Kirill V.} and Koptyug, {Igor V.}",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = mar,
doi = "10.1038/s41598-021-85136-2",
language = "English",
volume = "11",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - PHIP hyperpolarized [1-13C]pyruvate and [1-13C]acetate esters via PH-INEPT polarization transfer monitored by 13C NMR and MRI

AU - Svyatova, Alexandra

AU - Kozinenko, Vitaly P.

AU - Chukanov, Nikita V.

AU - Burueva, Dudari B.

AU - Chekmenev, Eduard Y.

AU - Chen, Yu Wen

AU - Hwang, Dennis W.

AU - Kovtunov, Kirill V.

AU - Koptyug, Igor V.

N1 - Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/3

Y1 - 2021/3

N2 - Parahydrogen-induced polarization of 13C nuclei by side-arm hydrogenation (PHIP-SAH) for [1-13C]acetate and [1-13C]pyruvate esters with application of PH-INEPT-type pulse sequences for 1H to 13C polarization transfer is reported, and its efficiency is compared with that of polarization transfer based on magnetic field cycling (MFC). The pulse-sequence transfer approach may have its merits in some applications because the entire hyperpolarization procedure is implemented directly in an NMR or MRI instrument, whereas MFC requires a controlled field variation at low magnetic fields. Optimization of the PH-INEPT-type transfer sequences resulted in 13C polarization values of 0.66 ± 0.04% and 0.19 ± 0.02% for allyl [1-13C]pyruvate and ethyl [1-13C]acetate, respectively, which is lower than the corresponding polarization levels obtained with MFC for 1H to 13C polarization transfer (3.95 ± 0.05% and 0.65 ± 0.05% for allyl [1-13C]pyruvate and ethyl [1-13C]acetate, respectively). Nevertheless, a significant 13C NMR signal enhancement with respect to thermal polarization allowed us to perform 13C MR imaging of both biologically relevant hyperpolarized molecules which can be used to produce useful contrast agents for the in vivo imaging applications.

AB - Parahydrogen-induced polarization of 13C nuclei by side-arm hydrogenation (PHIP-SAH) for [1-13C]acetate and [1-13C]pyruvate esters with application of PH-INEPT-type pulse sequences for 1H to 13C polarization transfer is reported, and its efficiency is compared with that of polarization transfer based on magnetic field cycling (MFC). The pulse-sequence transfer approach may have its merits in some applications because the entire hyperpolarization procedure is implemented directly in an NMR or MRI instrument, whereas MFC requires a controlled field variation at low magnetic fields. Optimization of the PH-INEPT-type transfer sequences resulted in 13C polarization values of 0.66 ± 0.04% and 0.19 ± 0.02% for allyl [1-13C]pyruvate and ethyl [1-13C]acetate, respectively, which is lower than the corresponding polarization levels obtained with MFC for 1H to 13C polarization transfer (3.95 ± 0.05% and 0.65 ± 0.05% for allyl [1-13C]pyruvate and ethyl [1-13C]acetate, respectively). Nevertheless, a significant 13C NMR signal enhancement with respect to thermal polarization allowed us to perform 13C MR imaging of both biologically relevant hyperpolarized molecules which can be used to produce useful contrast agents for the in vivo imaging applications.

UR - http://www.scopus.com/inward/record.url?scp=85102478166&partnerID=8YFLogxK

U2 - 10.1038/s41598-021-85136-2

DO - 10.1038/s41598-021-85136-2

M3 - Article

C2 - 33707497

AN - SCOPUS:85102478166

VL - 11

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 5646

ER -

ID: 28089663