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Phenolic compounds from Glycyrrhiza pallidiflora Maxim. and their cytotoxic activity. / Shults, Elvira E.; Shakirov, Makhmut M.; Pokrovsky, Mikhail A. et al.

In: Natural Product Research, Vol. 31, No. 4, 02.2017, p. 445-452.

Research output: Contribution to journalArticlepeer-review

Harvard

Shults, EE, Shakirov, MM, Pokrovsky, MA, Petrova, TN, Pokrovsky, AG & Gorovoy, PG 2017, 'Phenolic compounds from Glycyrrhiza pallidiflora Maxim. and their cytotoxic activity', Natural Product Research, vol. 31, no. 4, pp. 445-452. https://doi.org/10.1080/14786419.2016.1188094

APA

Shults, E. E., Shakirov, M. M., Pokrovsky, M. A., Petrova, T. N., Pokrovsky, A. G., & Gorovoy, P. G. (2017). Phenolic compounds from Glycyrrhiza pallidiflora Maxim. and their cytotoxic activity. Natural Product Research, 31(4), 445-452. https://doi.org/10.1080/14786419.2016.1188094

Vancouver

Shults EE, Shakirov MM, Pokrovsky MA, Petrova TN, Pokrovsky AG, Gorovoy PG. Phenolic compounds from Glycyrrhiza pallidiflora Maxim. and their cytotoxic activity. Natural Product Research. 2017 Feb;31(4):445-452. doi: 10.1080/14786419.2016.1188094

Author

Shults, Elvira E. ; Shakirov, Makhmut M. ; Pokrovsky, Mikhail A. et al. / Phenolic compounds from Glycyrrhiza pallidiflora Maxim. and their cytotoxic activity. In: Natural Product Research. 2017 ; Vol. 31, No. 4. pp. 445-452.

BibTeX

@article{1d3d2914e26a4a9cb4409de524d6d98c,
title = "Phenolic compounds from Glycyrrhiza pallidiflora Maxim. and their cytotoxic activity",
abstract = "Twenty-one phenolic compounds (1–21) including dihydrocinnamic acid, isoflavonoids, flavonoids, coumestans, pterocarpans, chalcones, isoflavan and isoflaven, were isolated from the roots of Glycyrrhiza pallidiflora Maxim. Phloretinic acid (1), chrysin (6), 9-methoxycoumestan (8), isoglycyrol (9), 6″-O-acetylanonin (19) and 6″-O-acetylwistin (21) were isolated from G. pallidiflora for the first time. Isoflavonoid acetylglycosides 19, 21 might be artefacts that could be produced during the EtOAc fractionation process of whole extract. Compounds 2–4, 10, 11, 19 and 21 were evaluated for their cytotoxic activity with respect to model cancer cell lines (CEM-13, MT-4, U-937) using the conventional MTT assays. Isoflavonoid calycosin (4) showed the best potency against human T-cell leukaemia cells MT-4 (CTD50, 2.9 μM). Pterocarpans medicarpin (10) and homopterocarpin (11) exhibit anticancer activity in micromolar range with selectivity on the human monocyte cells U-937. The isoflavan (3R)-vestitol (16) was highly selective on the lymphoblastoid leukaemia cells CEM-13 and was more active than the drug doxorubicin",
keywords = "cytotoxic activity, flavonoids, Glycyrrhiza pallidiflora, isoflavonoids, pterocarpans, Plant Roots/chemistry, Glycyrrhiza/chemistry, Humans, Antineoplastic Agents, Phytogenic/pharmacology, Cell Line, Tumor, Phenols/chemistry, GLABRA, GLYCOSIDES, GLYCYROL, URALENSIS, FLAVONOIDS, ANTIOXIDANT, ISOFLAVONOIDS, DERIVATIVES, LICORICE ROOT, CONSTITUENTS",
author = "Shults, {Elvira E.} and Shakirov, {Makhmut M.} and Pokrovsky, {Mikhail A.} and Petrova, {Tatijana N.} and Pokrovsky, {Andrey G.} and Gorovoy, {Petr G.}",
year = "2017",
month = feb,
doi = "10.1080/14786419.2016.1188094",
language = "English",
volume = "31",
pages = "445--452",
journal = "Natural Product Research",
issn = "1478-6419",
publisher = "Taylor and Francis Ltd.",
number = "4",

}

RIS

TY - JOUR

T1 - Phenolic compounds from Glycyrrhiza pallidiflora Maxim. and their cytotoxic activity

AU - Shults, Elvira E.

AU - Shakirov, Makhmut M.

AU - Pokrovsky, Mikhail A.

AU - Petrova, Tatijana N.

AU - Pokrovsky, Andrey G.

AU - Gorovoy, Petr G.

PY - 2017/2

Y1 - 2017/2

N2 - Twenty-one phenolic compounds (1–21) including dihydrocinnamic acid, isoflavonoids, flavonoids, coumestans, pterocarpans, chalcones, isoflavan and isoflaven, were isolated from the roots of Glycyrrhiza pallidiflora Maxim. Phloretinic acid (1), chrysin (6), 9-methoxycoumestan (8), isoglycyrol (9), 6″-O-acetylanonin (19) and 6″-O-acetylwistin (21) were isolated from G. pallidiflora for the first time. Isoflavonoid acetylglycosides 19, 21 might be artefacts that could be produced during the EtOAc fractionation process of whole extract. Compounds 2–4, 10, 11, 19 and 21 were evaluated for their cytotoxic activity with respect to model cancer cell lines (CEM-13, MT-4, U-937) using the conventional MTT assays. Isoflavonoid calycosin (4) showed the best potency against human T-cell leukaemia cells MT-4 (CTD50, 2.9 μM). Pterocarpans medicarpin (10) and homopterocarpin (11) exhibit anticancer activity in micromolar range with selectivity on the human monocyte cells U-937. The isoflavan (3R)-vestitol (16) was highly selective on the lymphoblastoid leukaemia cells CEM-13 and was more active than the drug doxorubicin

AB - Twenty-one phenolic compounds (1–21) including dihydrocinnamic acid, isoflavonoids, flavonoids, coumestans, pterocarpans, chalcones, isoflavan and isoflaven, were isolated from the roots of Glycyrrhiza pallidiflora Maxim. Phloretinic acid (1), chrysin (6), 9-methoxycoumestan (8), isoglycyrol (9), 6″-O-acetylanonin (19) and 6″-O-acetylwistin (21) were isolated from G. pallidiflora for the first time. Isoflavonoid acetylglycosides 19, 21 might be artefacts that could be produced during the EtOAc fractionation process of whole extract. Compounds 2–4, 10, 11, 19 and 21 were evaluated for their cytotoxic activity with respect to model cancer cell lines (CEM-13, MT-4, U-937) using the conventional MTT assays. Isoflavonoid calycosin (4) showed the best potency against human T-cell leukaemia cells MT-4 (CTD50, 2.9 μM). Pterocarpans medicarpin (10) and homopterocarpin (11) exhibit anticancer activity in micromolar range with selectivity on the human monocyte cells U-937. The isoflavan (3R)-vestitol (16) was highly selective on the lymphoblastoid leukaemia cells CEM-13 and was more active than the drug doxorubicin

KW - cytotoxic activity

KW - flavonoids

KW - Glycyrrhiza pallidiflora

KW - isoflavonoids

KW - pterocarpans

KW - Plant Roots/chemistry

KW - Glycyrrhiza/chemistry

KW - Humans

KW - Antineoplastic Agents, Phytogenic/pharmacology

KW - Cell Line, Tumor

KW - Phenols/chemistry

KW - GLABRA

KW - GLYCOSIDES

KW - GLYCYROL

KW - URALENSIS

KW - FLAVONOIDS

KW - ANTIOXIDANT

KW - ISOFLAVONOIDS

KW - DERIVATIVES

KW - LICORICE ROOT

KW - CONSTITUENTS

UR - http://www.scopus.com/inward/record.url?scp=84969816543&partnerID=8YFLogxK

U2 - 10.1080/14786419.2016.1188094

DO - 10.1080/14786419.2016.1188094

M3 - Article

C2 - 27210480

AN - SCOPUS:84969816543

VL - 31

SP - 445

EP - 452

JO - Natural Product Research

JF - Natural Product Research

SN - 1478-6419

IS - 4

ER -

ID: 8688334