Phenolic compounds from Glycyrrhiza pallidiflora Maxim. and their cytotoxic activity. / Shults, Elvira E.; Shakirov, Makhmut M.; Pokrovsky, Mikhail A. et al.
In: Natural Product Research, Vol. 31, No. 4, 02.2017, p. 445-452.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Phenolic compounds from Glycyrrhiza pallidiflora Maxim. and their cytotoxic activity
AU - Shults, Elvira E.
AU - Shakirov, Makhmut M.
AU - Pokrovsky, Mikhail A.
AU - Petrova, Tatijana N.
AU - Pokrovsky, Andrey G.
AU - Gorovoy, Petr G.
PY - 2017/2
Y1 - 2017/2
N2 - Twenty-one phenolic compounds (1–21) including dihydrocinnamic acid, isoflavonoids, flavonoids, coumestans, pterocarpans, chalcones, isoflavan and isoflaven, were isolated from the roots of Glycyrrhiza pallidiflora Maxim. Phloretinic acid (1), chrysin (6), 9-methoxycoumestan (8), isoglycyrol (9), 6″-O-acetylanonin (19) and 6″-O-acetylwistin (21) were isolated from G. pallidiflora for the first time. Isoflavonoid acetylglycosides 19, 21 might be artefacts that could be produced during the EtOAc fractionation process of whole extract. Compounds 2–4, 10, 11, 19 and 21 were evaluated for their cytotoxic activity with respect to model cancer cell lines (CEM-13, MT-4, U-937) using the conventional MTT assays. Isoflavonoid calycosin (4) showed the best potency against human T-cell leukaemia cells MT-4 (CTD50, 2.9 μM). Pterocarpans medicarpin (10) and homopterocarpin (11) exhibit anticancer activity in micromolar range with selectivity on the human monocyte cells U-937. The isoflavan (3R)-vestitol (16) was highly selective on the lymphoblastoid leukaemia cells CEM-13 and was more active than the drug doxorubicin
AB - Twenty-one phenolic compounds (1–21) including dihydrocinnamic acid, isoflavonoids, flavonoids, coumestans, pterocarpans, chalcones, isoflavan and isoflaven, were isolated from the roots of Glycyrrhiza pallidiflora Maxim. Phloretinic acid (1), chrysin (6), 9-methoxycoumestan (8), isoglycyrol (9), 6″-O-acetylanonin (19) and 6″-O-acetylwistin (21) were isolated from G. pallidiflora for the first time. Isoflavonoid acetylglycosides 19, 21 might be artefacts that could be produced during the EtOAc fractionation process of whole extract. Compounds 2–4, 10, 11, 19 and 21 were evaluated for their cytotoxic activity with respect to model cancer cell lines (CEM-13, MT-4, U-937) using the conventional MTT assays. Isoflavonoid calycosin (4) showed the best potency against human T-cell leukaemia cells MT-4 (CTD50, 2.9 μM). Pterocarpans medicarpin (10) and homopterocarpin (11) exhibit anticancer activity in micromolar range with selectivity on the human monocyte cells U-937. The isoflavan (3R)-vestitol (16) was highly selective on the lymphoblastoid leukaemia cells CEM-13 and was more active than the drug doxorubicin
KW - cytotoxic activity
KW - flavonoids
KW - Glycyrrhiza pallidiflora
KW - isoflavonoids
KW - pterocarpans
KW - Plant Roots/chemistry
KW - Glycyrrhiza/chemistry
KW - Humans
KW - Antineoplastic Agents, Phytogenic/pharmacology
KW - Cell Line, Tumor
KW - Phenols/chemistry
KW - GLABRA
KW - GLYCOSIDES
KW - GLYCYROL
KW - URALENSIS
KW - FLAVONOIDS
KW - ANTIOXIDANT
KW - ISOFLAVONOIDS
KW - DERIVATIVES
KW - LICORICE ROOT
KW - CONSTITUENTS
UR - http://www.scopus.com/inward/record.url?scp=84969816543&partnerID=8YFLogxK
U2 - 10.1080/14786419.2016.1188094
DO - 10.1080/14786419.2016.1188094
M3 - Article
C2 - 27210480
AN - SCOPUS:84969816543
VL - 31
SP - 445
EP - 452
JO - Natural Product Research
JF - Natural Product Research
SN - 1478-6419
IS - 4
ER -
ID: 8688334