Research output: Contribution to journal › Article › peer-review
Peculiarities in Interaction of Independent Components of Resting-State fMRI Signal in Patients with Mild Depressions. / Mel’nikov, M. E.; Bezmaternykh, D. D.; Petrovskii, E. D. et al.
In: Bulletin of Experimental Biology and Medicine, Vol. 163, No. 4, 01.08.2017, p. 497-499.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Peculiarities in Interaction of Independent Components of Resting-State fMRI Signal in Patients with Mild Depressions
AU - Mel’nikov, M. E.
AU - Bezmaternykh, D. D.
AU - Petrovskii, E. D.
AU - Kozlova, L. I.
AU - Shtark, M. B.
AU - Savelov, A. A.
AU - Shubina, O. S.
AU - Natarova, K. A.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Some aspects of resting-state fMRI signal can be the key markers of depression. fMRI was recoded over 4 min in evidently healthy persons (N=21) and in patients with mild depression (N=21). The data were separated into the independent spatial components, and the strength of their association with established brain networks was analyzed. The patients with mild depression were characterized with greater correlations between the components representing the ventral and dorsal subdivisions of default mode network (DMN), whereas correlations between the components relating to cerebellum and to the left hemisphere language system were less pronounced. The data revealed a significant role of DMN in the development of affective abnormalities and importance of its functional state as a probable marker of mild depression.
AB - Some aspects of resting-state fMRI signal can be the key markers of depression. fMRI was recoded over 4 min in evidently healthy persons (N=21) and in patients with mild depression (N=21). The data were separated into the independent spatial components, and the strength of their association with established brain networks was analyzed. The patients with mild depression were characterized with greater correlations between the components representing the ventral and dorsal subdivisions of default mode network (DMN), whereas correlations between the components relating to cerebellum and to the left hemisphere language system were less pronounced. The data revealed a significant role of DMN in the development of affective abnormalities and importance of its functional state as a probable marker of mild depression.
KW - analysis of independent components
KW - default mode network
KW - depression
KW - resting-state fMRI
UR - http://www.scopus.com/inward/record.url?scp=85028753010&partnerID=8YFLogxK
U2 - 10.1007/s10517-017-3837-4
DO - 10.1007/s10517-017-3837-4
M3 - Article
AN - SCOPUS:85028753010
VL - 163
SP - 497
EP - 499
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 4
ER -
ID: 9915703