Research output: Contribution to journal › Review article › peer-review
On Problems of the Comprehensive Chemical Profiling of Medicinal Plants. / Morozov, S. V.; Tkacheva, N. I.; Tkachev, A. V.
In: Russian Journal of Bioorganic Chemistry, Vol. 45, No. 7, 01.12.2019, p. 860-875.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - On Problems of the Comprehensive Chemical Profiling of Medicinal Plants
AU - Morozov, S. V.
AU - Tkacheva, N. I.
AU - Tkachev, A. V.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - The interest in and attention to herbal therapy rise in Russia every year, which is in agreement with the worldwide tendency. Support for the increasing demand inescapably leads to the appearance of the herbal products with low quality and efficacy, and sometimes to the total falsification of plant material and preparations based on it. Therefore, one of the important problems in medicine, biomedicine, pharmacognosy and phytochemistry is the pharmaceutical safety and quality of plant materials, plant preparations and herbal drugs. Modern methodological approaches to the solution of such problems, the different concepts of identification, evaluation of authenticity and quality control of herbal drugs using markers of different types and the instrumental methods of chromatographic profiling (one of the methods of metabolic investigations) of herbal compositions, the spectral and the combined spectral chromatographic methods used for solving these problems, the problems of the standardization of plant materials, the preparations and drugs based on it, the world experience in solving problems of the quality evaluation of plant materials and herbal products, and the state of research in Russia are observed in this review.
AB - The interest in and attention to herbal therapy rise in Russia every year, which is in agreement with the worldwide tendency. Support for the increasing demand inescapably leads to the appearance of the herbal products with low quality and efficacy, and sometimes to the total falsification of plant material and preparations based on it. Therefore, one of the important problems in medicine, biomedicine, pharmacognosy and phytochemistry is the pharmaceutical safety and quality of plant materials, plant preparations and herbal drugs. Modern methodological approaches to the solution of such problems, the different concepts of identification, evaluation of authenticity and quality control of herbal drugs using markers of different types and the instrumental methods of chromatographic profiling (one of the methods of metabolic investigations) of herbal compositions, the spectral and the combined spectral chromatographic methods used for solving these problems, the problems of the standardization of plant materials, the preparations and drugs based on it, the world experience in solving problems of the quality evaluation of plant materials and herbal products, and the state of research in Russia are observed in this review.
KW - chemical markers
KW - chromatographic fingerprint
KW - identification
KW - medicinal plants
KW - metabolomics
KW - pharmaceutical safety
KW - pharmacognosy
KW - spectral profiles
KW - NUCLEAR-MAGNETIC-RESONANCE
KW - DRUG DISCOVERY
KW - DATA-ACQUISITION
KW - QUALITY-CONTROL
KW - MASS-SPECTROMETRY
KW - METABOLOMICS
KW - LIQUID-CHROMATOGRAPHY
KW - QUANTITATIVE NMR
KW - NATURAL-PRODUCTS RESEARCH
KW - METABOLITE
UR - http://www.scopus.com/inward/record.url?scp=85078755186&partnerID=8YFLogxK
U2 - 10.1134/S1068162019070070
DO - 10.1134/S1068162019070070
M3 - Review article
AN - SCOPUS:85078755186
VL - 45
SP - 860
EP - 875
JO - Russian Journal of Bioorganic Chemistry
JF - Russian Journal of Bioorganic Chemistry
SN - 1068-1620
IS - 7
ER -
ID: 23327859