Novel semisynthetic derivatives of bile acids as effective tyrosyl-DNA phosphodiesterase 1 inhibitors

Research output: Contribution to journal › Article › peer-review

Amide, Cancer, Chenodeoxycholic acid, Deoxycholic acid, Molecular modelling, Tdp1 inhibitor, Tumor, Ursodeoxycholic acid, Virtual screening, HCT116 Cells, Humans, Bile Acids and Salts/chemical synthesis, Phosphodiesterase Inhibitors/chemical synthesis, Phosphoric Diester Hydrolases/metabolism, MCF-7 Cells, Molecular Docking Simulation, Drug Evaluation, Preclinical, Binding Sites, Niacinamide/analogs & derivatives, Tryptamines/chemical synthesis, STRAND BREAK REPAIR, virtual screening, HUMAN-CELLS, TOPOISOMERASE-I, deoxycholic acid, ursodeoxycholic acid, CAMPTOTHECIN, BIOLOGICAL EVALUATION, CHEMISTRY, molecular modelling, DAMAGE, ANTICANCER, amide, TDP1, tumor, cancer, BINDING, chenodeoxycholic acid

ID: 12214493