Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1415-1429
Number of pages	15
Journal	Journal of Enzyme Inhibition and Medicinal Chemistry
Volume	33
Issue number	1
DOIs	https://doi.org/10.1080/14756366.2018.1509210
Publication status	Published - 7 Sept 2018

Disaccharide nucleosides, TDP1 inhibitor, topotecan, tyrosyl-DNA phosphodiesterase 1, Humans, Cells, Cultured, Structure-Activity Relationship, Phosphodiesterase Inhibitors/chemical synthesis, Topotecan/chemical synthesis, Antineoplastic Agents/chemical synthesis, Phosphoric Diester Hydrolases/metabolism, Dose-Response Relationship, Drug, Nucleosides/chemical synthesis, Molecular Structure, Cell Proliferation/drug effects, Disaccharides/chemical synthesis, Drug Screening Assays, Antitumor, POLY(ADP-RIBOSE) POLYMERASE, HUMAN-CELLS, TOPOISOMERASE-I, SPINOCEREBELLAR ATAXIA, DERIVATIVES, REPAIR ENZYME, CRYSTAL-STRUCTURE, DAMAGE, TDP1, PYRIMIDINE NUCLEOSIDES

ID: 16484625