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Novel Bisimidazole-Containing Peptidomimetic Molecules for Мetal-Independent RNA Cleavage : Synthesis and Solid-Phase Screening Method. / Pavlova, A. S.; Ogurtsova, P. A.; Koroleva, L. S. et al.

In: Russian Journal of Bioorganic Chemistry, Vol. 45, No. 6, 01.11.2019, p. 813-824.

Research output: Contribution to journal › Article › peer-review

Harvard

Pavlova, AS, Ogurtsova, PA, Koroleva, LS, Serpokrylova, IY, Lomzov, AA, Pyshnaya, IA, Silnikov, VN & Pyshnyi, DV 2019, 'Novel Bisimidazole-Containing Peptidomimetic Molecules for Мetal-Independent RNA Cleavage: Synthesis and Solid-Phase Screening Method', Russian Journal of Bioorganic Chemistry, vol. 45, no. 6, pp. 813-824. https://doi.org/10.1134/S1068162019060311

APA

Pavlova, A. S., Ogurtsova, P. A., Koroleva, L. S., Serpokrylova, I. Y., Lomzov, A. A., Pyshnaya, I. A., Silnikov, V. N., & Pyshnyi, D. V. (2019). Novel Bisimidazole-Containing Peptidomimetic Molecules for Мetal-Independent RNA Cleavage: Synthesis and Solid-Phase Screening Method. Russian Journal of Bioorganic Chemistry, 45(6), 813-824. https://doi.org/10.1134/S1068162019060311

Vancouver

Pavlova AS, Ogurtsova PA, Koroleva LS, Serpokrylova IY, Lomzov AA, Pyshnaya IA et al. Novel Bisimidazole-Containing Peptidomimetic Molecules for Мetal-Independent RNA Cleavage: Synthesis and Solid-Phase Screening Method. Russian Journal of Bioorganic Chemistry. 2019 Nov 1;45(6):813-824. doi: 10.1134/S1068162019060311

Author

Pavlova, A. S. ; Ogurtsova, P. A. ; Koroleva, L. S. et al. / Novel Bisimidazole-Containing Peptidomimetic Molecules for Мetal-Independent RNA Cleavage : Synthesis and Solid-Phase Screening Method. In: Russian Journal of Bioorganic Chemistry. 2019 ; Vol. 45, No. 6. pp. 813-824.

BibTeX

@article{af3cad1644ec4a92b20385f36c724e4b,
title = "Novel Bisimidazole-Containing Peptidomimetic Molecules for Мetal-Independent RNA Cleavage: Synthesis and Solid-Phase Screening Method",
abstract = "Novel bisimidazole-containing peptidomimetic molecules, which can efficiently cleave RNA in the absence of divalent metal ions have been synthesized. The thymidine 5'-monophosphate derivatives modified with these peptidomimetics have been obtained on CPG (controlled pore glass) using a solid phase azide-alkyne cycloaddition. The ability of all synthesized derivatives to cleave RNA has been demonstrated by a solid-phase screening method. The resulting conjugates have provided a 20–100% cleavage of the RNA target in 18 hours. The results allow us to consider the described strategy as a useful approach for the rapid selection of potentially promising peptidomimetic molecules in order to synthesize reactive constructs on their basis.",
keywords = "artificial nucleases, azide-alkyne cycloaddition, CPG, imidazole, RNA cleavage, solid-phase screening, DESIGN, CLICK CHEMISTRY, LIGATION, CYCLOADDITION, NUCLEOSIDE, PEPTIDES, SEQUENCE-SPECIFIC CLEAVAGE, IMIDAZOLE, ANTISENSE OLIGONUCLEOTIDES, RIBONUCLEASE",
author = "Pavlova, {A. S.} and Ogurtsova, {P. A.} and Koroleva, {L. S.} and Serpokrylova, {I. Y.} and Lomzov, {A. A.} and Pyshnaya, {I. A.} and Silnikov, {V. N.} and Pyshnyi, {D. V.}",
note = "Publisher Copyright: {\textcopyright} 2019, Pleiades Publishing, Ltd.",
year = "2019",
month = nov,
day = "1",
doi = "10.1134/S1068162019060311",
language = "English",
volume = "45",
pages = "813--824",
journal = "Russian Journal of Bioorganic Chemistry",
issn = "1068-1620",
publisher = "MAIK NAUKA/INTERPERIODICA/SPRINGER",
number = "6",

}

RIS

TY - JOUR

T1 - Novel Bisimidazole-Containing Peptidomimetic Molecules for Мetal-Independent RNA Cleavage

T2 - Synthesis and Solid-Phase Screening Method

AU - Pavlova, A. S.

AU - Ogurtsova, P. A.

AU - Koroleva, L. S.

AU - Serpokrylova, I. Y.

AU - Lomzov, A. A.

AU - Pyshnaya, I. A.

AU - Silnikov, V. N.

AU - Pyshnyi, D. V.

N1 - Publisher Copyright: © 2019, Pleiades Publishing, Ltd.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Novel bisimidazole-containing peptidomimetic molecules, which can efficiently cleave RNA in the absence of divalent metal ions have been synthesized. The thymidine 5'-monophosphate derivatives modified with these peptidomimetics have been obtained on CPG (controlled pore glass) using a solid phase azide-alkyne cycloaddition. The ability of all synthesized derivatives to cleave RNA has been demonstrated by a solid-phase screening method. The resulting conjugates have provided a 20–100% cleavage of the RNA target in 18 hours. The results allow us to consider the described strategy as a useful approach for the rapid selection of potentially promising peptidomimetic molecules in order to synthesize reactive constructs on their basis.

AB - Novel bisimidazole-containing peptidomimetic molecules, which can efficiently cleave RNA in the absence of divalent metal ions have been synthesized. The thymidine 5'-monophosphate derivatives modified with these peptidomimetics have been obtained on CPG (controlled pore glass) using a solid phase azide-alkyne cycloaddition. The ability of all synthesized derivatives to cleave RNA has been demonstrated by a solid-phase screening method. The resulting conjugates have provided a 20–100% cleavage of the RNA target in 18 hours. The results allow us to consider the described strategy as a useful approach for the rapid selection of potentially promising peptidomimetic molecules in order to synthesize reactive constructs on their basis.

KW - artificial nucleases

KW - azide-alkyne cycloaddition

KW - CPG

KW - imidazole

KW - RNA cleavage

KW - solid-phase screening

KW - DESIGN

KW - CLICK CHEMISTRY

KW - LIGATION

KW - CYCLOADDITION

KW - NUCLEOSIDE

KW - PEPTIDES

KW - SEQUENCE-SPECIFIC CLEAVAGE

KW - IMIDAZOLE

KW - ANTISENSE OLIGONUCLEOTIDES

KW - RIBONUCLEASE

UR - http://www.scopus.com/inward/record.url?scp=85078624476&partnerID=8YFLogxK

U2 - 10.1134/S1068162019060311

DO - 10.1134/S1068162019060311

M3 - Article

AN - SCOPUS:85078624476

VL - 45

SP - 813

EP - 824

JO - Russian Journal of Bioorganic Chemistry

JF - Russian Journal of Bioorganic Chemistry

SN - 1068-1620

IS - 6

ER -

ID: 23256689