Non-pharmacological and pharmacological approaches for psychiatric disorders

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Non-pharmacological and pharmacological approaches for psychiatric disorders : Re-appraisal and insights from zebrafish models. / de Abreu, Murilo S.; Giacomini, Ana C.V.V.; Genario, Rafael et al.

In: Pharmacology Biochemistry and Behavior, Vol. 193, 172928, 06.2020.

Research output: Contribution to journal › Review article › peer-review

Harvard

de Abreu, MS, Giacomini, ACVV, Genario, R, Rech, N, Carboni, J, Lakstygal, AM, Amstislavskaya, TG, Demin, KA, Leonard, BE, Vlok, M, Harvey, BH, Piato, A, Barcellos, LJG & Kalueff, AV 2020, 'Non-pharmacological and pharmacological approaches for psychiatric disorders: Re-appraisal and insights from zebrafish models', Pharmacology Biochemistry and Behavior, vol. 193, 172928. https://doi.org/10.1016/j.pbb.2020.172928

APA

de Abreu, M. S., Giacomini, A. C. V. V., Genario, R., Rech, N., Carboni, J., Lakstygal, A. M., Amstislavskaya, T. G., Demin, K. A., Leonard, B. E., Vlok, M., Harvey, B. H., Piato, A., Barcellos, L. J. G., & Kalueff, A. V. (2020). Non-pharmacological and pharmacological approaches for psychiatric disorders: Re-appraisal and insights from zebrafish models. Pharmacology Biochemistry and Behavior, 193, [172928]. https://doi.org/10.1016/j.pbb.2020.172928

Vancouver

de Abreu MS, Giacomini ACVV, Genario R, Rech N, Carboni J, Lakstygal AM et al. Non-pharmacological and pharmacological approaches for psychiatric disorders: Re-appraisal and insights from zebrafish models. Pharmacology Biochemistry and Behavior. 2020 Jun;193:172928. Epub 2020 Apr 11. doi: 10.1016/j.pbb.2020.172928

Author

de Abreu, Murilo S. ; Giacomini, Ana C.V.V. ; Genario, Rafael et al. / Non-pharmacological and pharmacological approaches for psychiatric disorders : Re-appraisal and insights from zebrafish models. In: Pharmacology Biochemistry and Behavior. 2020 ; Vol. 193.

BibTeX

@article{a115189973dc48e484afb7dd586383a5,

title = "Non-pharmacological and pharmacological approaches for psychiatric disorders: Re-appraisal and insights from zebrafish models",

abstract = "Acute and chronic stressors are common triggers of human mental illnesses. Experimental animal models and their cross-species translation to humans are critical for understanding of the pathogenesis of stress-related psychiatric disorders. Mounting evidence suggests that both pharmacological and non-pharmacological approaches can be efficient in treating these disorders. Here, we analyze human, rodent and zebrafish (Danio rerio) data to compare the impact of non-pharmacological and pharmacological therapies of stress-related psychopathologies. Emphasizing the likely synergism and interplay between pharmacological and environmental factors in mitigating daily stress both clinically and in experimental models, we argue that environmental enrichment emerges as a promising complementary therapy for stress-induced disorders across taxa. We also call for a broader use of novel model organisms, such as zebrafish, to study such treatments and their potential interplay.",

keywords = "Acute and chronic stress, Animal model, Environmental enrichment, Mental illness, Psychopharmacotherapy, DANIO-RERIO, GENERALIZED ANXIETY DISORDER, ACUTE RESTRAINT STRESS, ENVIRONMENTAL ENRICHMENT, CHRONIC MILD STRESS, ADULT ZEBRAFISH, NEUROTRANSMITTER SYSTEMS, DEPRESSION-LIKE BEHAVIOR, TIME-DEPENDENT SENSITIZATION, ANIMAL-MODELS",

author = "{de Abreu}, {Murilo S.} and Giacomini, {Ana C.V.V.} and Rafael Genario and Nath{\'a}lia Rech and J{\'u}lia Carboni and Lakstygal, {Anton M.} and Amstislavskaya, {Tamara G.} and Demin, {Konstantin A.} and Leonard, {Brian E.} and Marli Vlok and Harvey, {Brian H.} and Angelo Piato and Barcellos, {Leonardo J.G.} and Kalueff, {Allan V.}",

year = "2020",

month = jun,

doi = "10.1016/j.pbb.2020.172928",

language = "English",

volume = "193",

journal = "Pharmacology Biochemistry and Behavior",

issn = "0091-3057",

publisher = "Elsevier Science Inc.",

}

RIS

TY - JOUR

T1 - Non-pharmacological and pharmacological approaches for psychiatric disorders

T2 - Re-appraisal and insights from zebrafish models

AU - de Abreu, Murilo S.

AU - Giacomini, Ana C.V.V.

AU - Genario, Rafael

AU - Rech, Nathália

AU - Carboni, Júlia

AU - Lakstygal, Anton M.

AU - Amstislavskaya, Tamara G.

AU - Demin, Konstantin A.

AU - Leonard, Brian E.

AU - Vlok, Marli

AU - Harvey, Brian H.

AU - Piato, Angelo

AU - Barcellos, Leonardo J.G.

AU - Kalueff, Allan V.

PY - 2020/6

Y1 - 2020/6

N2 - Acute and chronic stressors are common triggers of human mental illnesses. Experimental animal models and their cross-species translation to humans are critical for understanding of the pathogenesis of stress-related psychiatric disorders. Mounting evidence suggests that both pharmacological and non-pharmacological approaches can be efficient in treating these disorders. Here, we analyze human, rodent and zebrafish (Danio rerio) data to compare the impact of non-pharmacological and pharmacological therapies of stress-related psychopathologies. Emphasizing the likely synergism and interplay between pharmacological and environmental factors in mitigating daily stress both clinically and in experimental models, we argue that environmental enrichment emerges as a promising complementary therapy for stress-induced disorders across taxa. We also call for a broader use of novel model organisms, such as zebrafish, to study such treatments and their potential interplay.

AB - Acute and chronic stressors are common triggers of human mental illnesses. Experimental animal models and their cross-species translation to humans are critical for understanding of the pathogenesis of stress-related psychiatric disorders. Mounting evidence suggests that both pharmacological and non-pharmacological approaches can be efficient in treating these disorders. Here, we analyze human, rodent and zebrafish (Danio rerio) data to compare the impact of non-pharmacological and pharmacological therapies of stress-related psychopathologies. Emphasizing the likely synergism and interplay between pharmacological and environmental factors in mitigating daily stress both clinically and in experimental models, we argue that environmental enrichment emerges as a promising complementary therapy for stress-induced disorders across taxa. We also call for a broader use of novel model organisms, such as zebrafish, to study such treatments and their potential interplay.

KW - Acute and chronic stress

KW - Animal model

KW - Environmental enrichment

KW - Mental illness

KW - Psychopharmacotherapy

KW - DANIO-RERIO

KW - GENERALIZED ANXIETY DISORDER

KW - ACUTE RESTRAINT STRESS

KW - ENVIRONMENTAL ENRICHMENT

KW - CHRONIC MILD STRESS

KW - ADULT ZEBRAFISH

KW - NEUROTRANSMITTER SYSTEMS

KW - DEPRESSION-LIKE BEHAVIOR

KW - TIME-DEPENDENT SENSITIZATION

KW - ANIMAL-MODELS

UR - http://www.scopus.com/inward/record.url?scp=85083882651&partnerID=8YFLogxK

U2 - 10.1016/j.pbb.2020.172928

DO - 10.1016/j.pbb.2020.172928

M3 - Review article

C2 - 32289330

AN - SCOPUS:85083882651

VL - 193

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

M1 - 172928

ER -

ID: 24162107