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Non-covalent anchoring of oligonucleotides on single-walled carbon nanotubes via short bioreducible linker. / Permyakova, Elizaveta S.; Novopashina, Darya S.; Venyaminova, Alya G. et al.

In: RSC Advances, Vol. 7, No. 46, 01.01.2017, p. 29212-29217.

Research output: Contribution to journal › Article › peer-review

Harvard

Permyakova, ES, Novopashina, DS, Venyaminova, AG & Apartsin, EK 2017, 'Non-covalent anchoring of oligonucleotides on single-walled carbon nanotubes via short bioreducible linker', RSC Advances, vol. 7, no. 46, pp. 29212-29217. https://doi.org/10.1039/c7ra04933a

APA

Permyakova, E. S., Novopashina, D. S., Venyaminova, A. G., & Apartsin, E. K. (2017). Non-covalent anchoring of oligonucleotides on single-walled carbon nanotubes via short bioreducible linker. RSC Advances, 7(46), 29212-29217. https://doi.org/10.1039/c7ra04933a

Vancouver

Permyakova ES, Novopashina DS, Venyaminova AG, Apartsin EK. Non-covalent anchoring of oligonucleotides on single-walled carbon nanotubes via short bioreducible linker. RSC Advances. 2017 Jan 1;7(46):29212-29217. doi: 10.1039/c7ra04933a

Author

Permyakova, Elizaveta S. ; Novopashina, Darya S. ; Venyaminova, Alya G. et al. / Non-covalent anchoring of oligonucleotides on single-walled carbon nanotubes via short bioreducible linker. In: RSC Advances. 2017 ; Vol. 7, No. 46. pp. 29212-29217.

BibTeX

@article{9fea92d324504e0282e4ee6b5f509203,
title = "Non-covalent anchoring of oligonucleotides on single-walled carbon nanotubes via short bioreducible linker",
abstract = "A novel, simple and convenient approach to assemble non-covalent hybrids of carbon nanotubes with therapeutic oligonucleotides immobilized by means of biodegradable linker is described. Model RNA, DNA and 2′-O-methyl RNA oligonucleotides were anchored on the surface of single-walled carbon nanotubes using pyrene anchor groups introduced onto the 5′-termini via short linker containing bioreducible disulfide bond or via stable linker of the similar length, as a control. To optimize the conditions of non-covalent functionalization, the adsorption of oligonucleotides' pyrene conjugates on the carbon nanotubes surface has been studied. The exposure of hybrids to glutathione at physiological concentrations has been shown to cause the release of oligonucleotides anchored via bioreducible linker only. The kinetic parameters of the oligonucleotides release have been determined for the first time. The results obtained can be useful for the design of carbon nanotubes-based nanoconstructions and biomaterials.",
author = "Permyakova, {Elizaveta S.} and Novopashina, {Darya S.} and Venyaminova, {Alya G.} and Apartsin, {Evgeny K.}",
year = "2017",
month = jan,
day = "1",
doi = "10.1039/c7ra04933a",
language = "English",
volume = "7",
pages = "29212--29217",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "ROYAL SOC CHEMISTRY",
number = "46",

}

RIS

TY - JOUR

T1 - Non-covalent anchoring of oligonucleotides on single-walled carbon nanotubes via short bioreducible linker

AU - Permyakova, Elizaveta S.

AU - Novopashina, Darya S.

AU - Venyaminova, Alya G.

AU - Apartsin, Evgeny K.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - A novel, simple and convenient approach to assemble non-covalent hybrids of carbon nanotubes with therapeutic oligonucleotides immobilized by means of biodegradable linker is described. Model RNA, DNA and 2′-O-methyl RNA oligonucleotides were anchored on the surface of single-walled carbon nanotubes using pyrene anchor groups introduced onto the 5′-termini via short linker containing bioreducible disulfide bond or via stable linker of the similar length, as a control. To optimize the conditions of non-covalent functionalization, the adsorption of oligonucleotides' pyrene conjugates on the carbon nanotubes surface has been studied. The exposure of hybrids to glutathione at physiological concentrations has been shown to cause the release of oligonucleotides anchored via bioreducible linker only. The kinetic parameters of the oligonucleotides release have been determined for the first time. The results obtained can be useful for the design of carbon nanotubes-based nanoconstructions and biomaterials.

AB - A novel, simple and convenient approach to assemble non-covalent hybrids of carbon nanotubes with therapeutic oligonucleotides immobilized by means of biodegradable linker is described. Model RNA, DNA and 2′-O-methyl RNA oligonucleotides were anchored on the surface of single-walled carbon nanotubes using pyrene anchor groups introduced onto the 5′-termini via short linker containing bioreducible disulfide bond or via stable linker of the similar length, as a control. To optimize the conditions of non-covalent functionalization, the adsorption of oligonucleotides' pyrene conjugates on the carbon nanotubes surface has been studied. The exposure of hybrids to glutathione at physiological concentrations has been shown to cause the release of oligonucleotides anchored via bioreducible linker only. The kinetic parameters of the oligonucleotides release have been determined for the first time. The results obtained can be useful for the design of carbon nanotubes-based nanoconstructions and biomaterials.

UR - http://www.scopus.com/inward/record.url?scp=85021655468&partnerID=8YFLogxK

U2 - 10.1039/c7ra04933a

DO - 10.1039/c7ra04933a

M3 - Article

AN - SCOPUS:85021655468

VL - 7

SP - 29212

EP - 29217

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 46

ER -

ID: 10098511