Research output: Contribution to journal › Article › peer-review
No alterations of brain structural asymmetry in major depressive disorder : An ENIGMA consortium analysis. / De Kovel, Carolien G.F.; Aftanas, Lyubomir; Aleman, André et al.
In: American Journal of Psychiatry, Vol. 176, No. 12, 12.2019, p. 1039-1049.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - No alterations of brain structural asymmetry in major depressive disorder
T2 - An ENIGMA consortium analysis
AU - De Kovel, Carolien G.F.
AU - Aftanas, Lyubomir
AU - Aleman, André
AU - Alexander-Bloch, Aaron F.
AU - Baune, Bernhard T.
AU - Brack, Ivan
AU - Bülow, Robin
AU - Filho, Geraldo Busatto
AU - Carballedo, Angela
AU - Connolly, Colm G.
AU - Cullen, Kathryn R.
AU - Dannlowski, Udo
AU - Davey, Christopher G.
AU - Dima, Danai
AU - Dohm, Katharina
AU - Erwin-Grabner, Tracy
AU - Frodl, Thomas
AU - Fu, Cynthia H.Y.
AU - Hall, Geoffrey B.
AU - Glahn, David C.
AU - Godlewska, Beata
AU - Gotlib, Ian H.
AU - Goya-Maldonado, Roberto
AU - Grabe, Hans Jörgen
AU - Groenewold, Nynke A.
AU - Grotegerd, Dominik
AU - Gruber, Oliver
AU - Harris, Mathew A.
AU - Harrison, Ben J.
AU - Hatton, Sean N.
AU - Hickie, Ian B.
AU - Ho, Tiffany C.
AU - Jahanshad, Neda
AU - Kircher, Tilo
AU - Krämer, Bernd
AU - Krug, Axel
AU - Lagopoulos, Jim
AU - Leehr, Elisabeth J.
AU - Li, Meng
AU - MacMaster, Frank P.
AU - MacQueen, Glenda
AU - McIntosh, Andrew M.
AU - McLellan, Quinn
AU - Medland, Sarah E.
AU - Mueller, Bryon A.
AU - Nenadic, Igor
AU - Osipov, Evgeny
AU - Papmeyer, Martina
AU - Portella, Maria J.
AU - Reneman, Liesbeth
AU - Rosa, Pedro G.P.
AU - Sacchet, Matthew D.
AU - Schnell, Knut
AU - Schrantee, Anouk
AU - Sim, Kang
AU - Simulionyte, Egle
AU - Sindermann, Lisa
AU - Singh, Aditya
AU - Stein, Dan J.
AU - Ubani, Benjamin N.
AU - Van Der Wee, Nic J.A.
AU - Van Der Werff, Steven J.A.
AU - Veer, Ilya M.
AU - Vives-Gilabert, Yolanda
AU - Völzke, Henry
AU - Walter, Henrik
AU - Walter, Martin
AU - Schreiner, Melinda Westlund
AU - Whalley, Heather
AU - Winter, Nils
AU - Wittfeld, Katharina
AU - Yang, Tony T.
AU - Yüksel, Dilara
AU - Zaremba, Dario
AU - Thompson, Paul M.
AU - Veltman, Dick J.
AU - Schmaal, Lianne
AU - Francks, Clyde
N1 - Publisher Copyright: © 2019 American Psychiatric Association. All rights reserved. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/12
Y1 - 2019/12
N2 - Objective: Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have specifically examined brain anatomical asymmetry in relation to this disorder, and results from those studies have remained inconclusive. At the functional level, some electroencephalography studies have indicated left fronto-cortical hypoactivity and right parietal hypoactivity in depressive disorders, so aspects of lateralized anatomy may also be affected. The authors used pooled individual-level data from data sets collected around the world to investigate differences in laterality in measures of cortical thickness, cortical surface area, and subcortical volume between individuals with major depression and healthy control subjects. Methods: The authors investigated differences in the laterality of thickness and surface area measures of 34 cerebral cortical regions in 2,256 individuals with major depression and 3,504 control subjects from 31 separate data sets, and they investigated volume asymmetries of eight subcortical structures in 2,540 individuals with major depression and 4,230 control subjects from 32 data sets. T1-weighted MRI data were processedwith a single protocol using FreeSurfer and the Desikan-Killiany atlas. The large sample size provided 80% power to detect effects of the order of Cohen's d=0.1. Results: The largest effect size (Cohen's d) of major depression diagnosis was 0.085 for the thickness asymmetry of the superior temporal cortex, which was not significant after adjustment for multiple testing. Asymmetry measures were not significantly associated with medication use, acute compared with remitted status, first episode compared with recurrent status, or age at onset. Conclusions: Altered brain macro-anatomical asymmetry may be of little relevance to major depression etiology in most cases.
AB - Objective: Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have specifically examined brain anatomical asymmetry in relation to this disorder, and results from those studies have remained inconclusive. At the functional level, some electroencephalography studies have indicated left fronto-cortical hypoactivity and right parietal hypoactivity in depressive disorders, so aspects of lateralized anatomy may also be affected. The authors used pooled individual-level data from data sets collected around the world to investigate differences in laterality in measures of cortical thickness, cortical surface area, and subcortical volume between individuals with major depression and healthy control subjects. Methods: The authors investigated differences in the laterality of thickness and surface area measures of 34 cerebral cortical regions in 2,256 individuals with major depression and 3,504 control subjects from 31 separate data sets, and they investigated volume asymmetries of eight subcortical structures in 2,540 individuals with major depression and 4,230 control subjects from 32 data sets. T1-weighted MRI data were processedwith a single protocol using FreeSurfer and the Desikan-Killiany atlas. The large sample size provided 80% power to detect effects of the order of Cohen's d=0.1. Results: The largest effect size (Cohen's d) of major depression diagnosis was 0.085 for the thickness asymmetry of the superior temporal cortex, which was not significant after adjustment for multiple testing. Asymmetry measures were not significantly associated with medication use, acute compared with remitted status, first episode compared with recurrent status, or age at onset. Conclusions: Altered brain macro-anatomical asymmetry may be of little relevance to major depression etiology in most cases.
KW - FRONTAL ALPHA ASYMMETRY
KW - EEG ASYMMETRY
KW - CORTEX
KW - SYMPTOMS
KW - MRI
KW - INDIVIDUALS
KW - ATTENUATION
KW - AGE
UR - http://www.scopus.com/inward/record.url?scp=85075265195&partnerID=8YFLogxK
U2 - 10.1176/appi.ajp.2019.18101144
DO - 10.1176/appi.ajp.2019.18101144
M3 - Article
C2 - 31352813
AN - SCOPUS:85075265195
VL - 176
SP - 1039
EP - 1049
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
SN - 0002-953X
IS - 12
ER -
ID: 22575978