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New reaction products of acetylacetone with semicarbazide derivatives. / Glukhacheva, Vera S.; Il'Yasov, Sergey G.; Kazantsev, Igor V. et al.

In: ACS Omega, Vol. 6, No. 12, 30.03.2021, p. 8637–8645.

Research output: Contribution to journal › Article › peer-review

Harvard

Glukhacheva, VS, Il'Yasov, SG, Kazantsev, IV, Shestakova, EO, Il'Yasov, DS, Eltsov, IV, Nefedov, AA & Gatilov, YV 2021, 'New reaction products of acetylacetone with semicarbazide derivatives', ACS Omega, vol. 6, no. 12, pp. 8637–8645. https://doi.org/10.1021/acsomega.1c00518

APA

Glukhacheva, V. S., Il'Yasov, S. G., Kazantsev, I. V., Shestakova, E. O., Il'Yasov, D. S., Eltsov, I. V., Nefedov, A. A., & Gatilov, Y. V. (2021). New reaction products of acetylacetone with semicarbazide derivatives. ACS Omega, 6(12), 8637–8645. https://doi.org/10.1021/acsomega.1c00518

Vancouver

Glukhacheva VS, Il'Yasov SG, Kazantsev IV, Shestakova EO, Il'Yasov DS, Eltsov IV et al. New reaction products of acetylacetone with semicarbazide derivatives. ACS Omega. 2021 Mar 30;6(12):8637–8645. doi: 10.1021/acsomega.1c00518

Author

Glukhacheva, Vera S. ; Il'Yasov, Sergey G. ; Kazantsev, Igor V. et al. / New reaction products of acetylacetone with semicarbazide derivatives. In: ACS Omega. 2021 ; Vol. 6, No. 12. pp. 8637–8645.

BibTeX

@article{d6585216a95540b1adcf042e80fb66b7,
title = "New reaction products of acetylacetone with semicarbazide derivatives",
abstract = "A new approach is suggested herein for the synthesis of pyrazole derivatives by reacting 4-nitrosemicarbazide with acetylacetone. Additional studies were done on the reaction of acetylacetone with semicarbazide and its derivatives (4-aminosemicarbazide, methylsemicarbazide, and dimethylsemicarbazide). The study on the reaction with acetylacetone resulted in monocyclic 3, 5-dimethyl-N-nitropyrazole-1-carboxamide, monocyclic 5-hydroxy-3, 5-dimethyl-2-pyrazoline, and bicyclic bis(3, 5- dimethylpyrazole-1-carbonyl)hydrazine, and conditions for the formation of acetone semicarbazone were identified. The structures of the resultant compounds were validated by physicochemical analytical methods, including X-ray diffraction. The computer-aided screening in the PASS prediction software discovered a high biological activity of the newly obtained compounds.",
author = "Glukhacheva, {Vera S.} and Il'Yasov, {Sergey G.} and Kazantsev, {Igor V.} and Shestakova, {Elena O.} and Il'Yasov, {Dmitri S.} and Eltsov, {Ilia V.} and Nefedov, {Andrey A.} and Gatilov, {Yuri V.}",
note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Published by American Chemical Society. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = mar,
day = "30",
doi = "10.1021/acsomega.1c00518",
language = "English",
volume = "6",
pages = "8637–8645",
journal = "ACS Omega",
issn = "2470-1343",
publisher = "American Chemical Society",
number = "12",

}

RIS

TY - JOUR

T1 - New reaction products of acetylacetone with semicarbazide derivatives

AU - Glukhacheva, Vera S.

AU - Il'Yasov, Sergey G.

AU - Kazantsev, Igor V.

AU - Shestakova, Elena O.

AU - Il'Yasov, Dmitri S.

AU - Eltsov, Ilia V.

AU - Nefedov, Andrey A.

AU - Gatilov, Yuri V.

N1 - Publisher Copyright: © 2021 The Authors. Published by American Chemical Society. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/3/30

Y1 - 2021/3/30

N2 - A new approach is suggested herein for the synthesis of pyrazole derivatives by reacting 4-nitrosemicarbazide with acetylacetone. Additional studies were done on the reaction of acetylacetone with semicarbazide and its derivatives (4-aminosemicarbazide, methylsemicarbazide, and dimethylsemicarbazide). The study on the reaction with acetylacetone resulted in monocyclic 3, 5-dimethyl-N-nitropyrazole-1-carboxamide, monocyclic 5-hydroxy-3, 5-dimethyl-2-pyrazoline, and bicyclic bis(3, 5- dimethylpyrazole-1-carbonyl)hydrazine, and conditions for the formation of acetone semicarbazone were identified. The structures of the resultant compounds were validated by physicochemical analytical methods, including X-ray diffraction. The computer-aided screening in the PASS prediction software discovered a high biological activity of the newly obtained compounds.

AB - A new approach is suggested herein for the synthesis of pyrazole derivatives by reacting 4-nitrosemicarbazide with acetylacetone. Additional studies were done on the reaction of acetylacetone with semicarbazide and its derivatives (4-aminosemicarbazide, methylsemicarbazide, and dimethylsemicarbazide). The study on the reaction with acetylacetone resulted in monocyclic 3, 5-dimethyl-N-nitropyrazole-1-carboxamide, monocyclic 5-hydroxy-3, 5-dimethyl-2-pyrazoline, and bicyclic bis(3, 5- dimethylpyrazole-1-carbonyl)hydrazine, and conditions for the formation of acetone semicarbazone were identified. The structures of the resultant compounds were validated by physicochemical analytical methods, including X-ray diffraction. The computer-aided screening in the PASS prediction software discovered a high biological activity of the newly obtained compounds.

UR - http://www.scopus.com/inward/record.url?scp=85103790709&partnerID=8YFLogxK

U2 - 10.1021/acsomega.1c00518

DO - 10.1021/acsomega.1c00518

M3 - Article

C2 - 33817525

AN - SCOPUS:85103790709

VL - 6

SP - 8637

EP - 8645

JO - ACS Omega

JF - ACS Omega

SN - 2470-1343

IS - 12

ER -

ID: 28317731