New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv

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New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv. / Yarovaya, Olga I.; Kovaleva, Kseniya S.; Zaykovskaya, Anna A. et al.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 40, 127926, 15.05.2021.

Research output: Contribution to journal › Article › peer-review

Harvard

Yarovaya, OI, Kovaleva, KS, Zaykovskaya, AA, Yashina, LN, Scherbakova, NS, Scherbakov, DN, Borisevich, SS, Zubkov, FI, Antonova, AS, Peshkov, RY , Eltsov, IV, Pyankov, OV, Maksyutov, RA & Salakhutdinov, NF 2021, 'New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv', Bioorganic and Medicinal Chemistry Letters, vol. 40, 127926. https://doi.org/10.1016/j.bmcl.2021.127926

APA

Yarovaya, O. I., Kovaleva, K. S., Zaykovskaya, A. A., Yashina, L. N., Scherbakova, N. S., Scherbakov, D. N., Borisevich, S. S., Zubkov, F. I., Antonova, A. S., Peshkov, R. Y., Eltsov, I. V., Pyankov, O. V., Maksyutov, R. A., & Salakhutdinov, N. F. (2021). New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv. Bioorganic and Medicinal Chemistry Letters, 40, [127926]. https://doi.org/10.1016/j.bmcl.2021.127926

Vancouver

Yarovaya OI, Kovaleva KS, Zaykovskaya AA, Yashina LN, Scherbakova NS, Scherbakov DN et al. New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv. Bioorganic and Medicinal Chemistry Letters. 2021 May 15;40:127926. Epub 2021 Mar 9. doi: 10.1016/j.bmcl.2021.127926

Author

Yarovaya, Olga I. ; Kovaleva, Kseniya S. ; Zaykovskaya, Anna A. et al. / New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv. In: Bioorganic and Medicinal Chemistry Letters. 2021 ; Vol. 40.

BibTeX

@article{a1e96ebff4214613b65d80a97ca9fbf4,

title = "New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv",

abstract = "This work presents the design and synthesis of camphor, fenchone, and norcamphor N-acylhydrazone derivatives as a new class of inhibitors of the Hantaan virus, which causes haemorrhagic fever with renal syndrome (HFRS). A cytopathic model was developed for testing chemotherapeutics against the Hantaan virus, strain 76–118. In addition, a study of the antiviral activity was carried out using a pseudoviral system. It was found that the hit compound possesses significant activity (IC50 = 7.6 ± 2 µM) along with low toxicity (CC50 > 1000 µM). Using molecular docking procedures, the binding with Hantavirus nucleoprotein was evaluated and the correlation between the structure of the synthesised compounds and the antiviral activity was established.",

keywords = "Antiviral, Hantavirus, HFRS, Isoindole, Terpene",

author = "Yarovaya, {Olga I.} and Kovaleva, {Kseniya S.} and Zaykovskaya, {Anna A.} and Yashina, {Liudmila N.} and Scherbakova, {Nadezda S.} and Scherbakov, {Dmitry N.} and Borisevich, {Sophia S.} and Zubkov, {Fedor I.} and Antonova, {Alexandra S.} and Peshkov, {Roman Yu} and Eltsov, {Ilia V.} and Pyankov, {Oleg V.} and Maksyutov, {Rinat A.} and Salakhutdinov, {Nariman F.}",

year = "2021",

month = may,

day = "15",

doi = "10.1016/j.bmcl.2021.127926",

language = "English",

volume = "40",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - New class of hantaan virus inhibitors based on conjugation of the isoindole fragment to (+)-camphor or (−)-fenchone hydrazonesv

AU - Yarovaya, Olga I.

AU - Kovaleva, Kseniya S.

AU - Zaykovskaya, Anna A.

AU - Yashina, Liudmila N.

AU - Scherbakova, Nadezda S.

AU - Scherbakov, Dmitry N.

AU - Borisevich, Sophia S.

AU - Zubkov, Fedor I.

AU - Antonova, Alexandra S.

AU - Peshkov, Roman Yu

AU - Eltsov, Ilia V.

AU - Pyankov, Oleg V.

AU - Maksyutov, Rinat A.

AU - Salakhutdinov, Nariman F.

PY - 2021/5/15

Y1 - 2021/5/15

N2 - This work presents the design and synthesis of camphor, fenchone, and norcamphor N-acylhydrazone derivatives as a new class of inhibitors of the Hantaan virus, which causes haemorrhagic fever with renal syndrome (HFRS). A cytopathic model was developed for testing chemotherapeutics against the Hantaan virus, strain 76–118. In addition, a study of the antiviral activity was carried out using a pseudoviral system. It was found that the hit compound possesses significant activity (IC50 = 7.6 ± 2 µM) along with low toxicity (CC50 > 1000 µM). Using molecular docking procedures, the binding with Hantavirus nucleoprotein was evaluated and the correlation between the structure of the synthesised compounds and the antiviral activity was established.

AB - This work presents the design and synthesis of camphor, fenchone, and norcamphor N-acylhydrazone derivatives as a new class of inhibitors of the Hantaan virus, which causes haemorrhagic fever with renal syndrome (HFRS). A cytopathic model was developed for testing chemotherapeutics against the Hantaan virus, strain 76–118. In addition, a study of the antiviral activity was carried out using a pseudoviral system. It was found that the hit compound possesses significant activity (IC50 = 7.6 ± 2 µM) along with low toxicity (CC50 > 1000 µM). Using molecular docking procedures, the binding with Hantavirus nucleoprotein was evaluated and the correlation between the structure of the synthesised compounds and the antiviral activity was established.

KW - Antiviral

KW - Hantavirus

KW - HFRS

KW - Isoindole

KW - Terpene

UR - http://www.scopus.com/inward/record.url?scp=85102584920&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2021.127926

DO - 10.1016/j.bmcl.2021.127926

M3 - Article

C2 - 33705902

AN - SCOPUS:85102584920

VL - 40

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

M1 - 127926

ER -

ID: 28079230