Neuroprotective effects of ceftriaxone treatment on cognitive and neuronal deficits in a rat model of accelerated senescence. / Tikhonova, Maria A.; Ho, Shih Chun; Akopyan, Anna A. et al.
In: Behavioural Brain Research, Vol. 330, 14.07.2017, p. 8-16.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Neuroprotective effects of ceftriaxone treatment on cognitive and neuronal deficits in a rat model of accelerated senescence
AU - Tikhonova, Maria A.
AU - Ho, Shih Chun
AU - Akopyan, Anna A.
AU - Kolosova, Nataliya G.
AU - Weng, Jun Cheng
AU - Meng, Wan Yun
AU - Lin, Chih Li
AU - Amstislavskaya, Tamara G.
AU - Ho, Ying Jui
N1 - Copyright © 2017 Elsevier B.V. All rights reserved.
PY - 2017/7/14
Y1 - 2017/7/14
N2 - Rats of OXYS strain are characterized by genetically defined accelerated senescence. Ceftriaxone (CEF) exerts neuroprotective effects by decreasing the excitotoxicity and activation of antioxidant system. Here, we studied the effects of CEF (50 or 100 mg/kg/day, i.p., 36 days) on cognitive and neuronal deficits in 5-month-old OXYS rats. Chronic CEF administration in a dose of 100 mg/kg partially inhibited impairments of movement and restored the deficit in the novel object recognition in OXYS rats. Neuromorphologically, control OXYS rats exhibited a lowered neuronal density in the hippocampal CA1 area and there was a tendency to decrease in the substantia nigra pars compacta compared to Wistar controls. Both doses of CEF increased the density of pyramidal neurons in the CA1 area in OXYS rats. Control OXYS rats demonstrated a tendency to lower tyrosine hydroxylase (TH) immunoreactivity in the striatum compared with Wistar rats, while CEF treatment at a dose of 50 mg/kg significantly augmented this parameter. In control OXYS rats, the levels of neurogenesis in the subgranular zone of the dentate gyrus of the hippocampus were significantly higher than in Wistar rats indicating compensatory processes that probably prevented the further induction of neurogenesis by CEF. Restoration of the recognition function and neuronal density in the CA1 area in OXYS rats after CEF treatment might be related to activation of the mechanisms that provide survival of newborn and mature neurons. The data suggested CEF as a promising pharmacological tool for the prevention of cognitive decline at accelerated aging.
AB - Rats of OXYS strain are characterized by genetically defined accelerated senescence. Ceftriaxone (CEF) exerts neuroprotective effects by decreasing the excitotoxicity and activation of antioxidant system. Here, we studied the effects of CEF (50 or 100 mg/kg/day, i.p., 36 days) on cognitive and neuronal deficits in 5-month-old OXYS rats. Chronic CEF administration in a dose of 100 mg/kg partially inhibited impairments of movement and restored the deficit in the novel object recognition in OXYS rats. Neuromorphologically, control OXYS rats exhibited a lowered neuronal density in the hippocampal CA1 area and there was a tendency to decrease in the substantia nigra pars compacta compared to Wistar controls. Both doses of CEF increased the density of pyramidal neurons in the CA1 area in OXYS rats. Control OXYS rats demonstrated a tendency to lower tyrosine hydroxylase (TH) immunoreactivity in the striatum compared with Wistar rats, while CEF treatment at a dose of 50 mg/kg significantly augmented this parameter. In control OXYS rats, the levels of neurogenesis in the subgranular zone of the dentate gyrus of the hippocampus were significantly higher than in Wistar rats indicating compensatory processes that probably prevented the further induction of neurogenesis by CEF. Restoration of the recognition function and neuronal density in the CA1 area in OXYS rats after CEF treatment might be related to activation of the mechanisms that provide survival of newborn and mature neurons. The data suggested CEF as a promising pharmacological tool for the prevention of cognitive decline at accelerated aging.
KW - Accelerated aging
KW - Ceftriaxone
KW - Cognitive deficit
KW - Hippocampus
KW - Neuroprotection
KW - Rats
KW - Tyrosine 3-Monooxygenase/analysis
KW - Rats, Wistar
KW - Male
KW - Neurons/drug effects
KW - Pars Compacta/drug effects
KW - Dentate Gyrus/drug effects
KW - Neurogenesis/drug effects
KW - Dopaminergic Neurons/drug effects
KW - Brain/drug effects
KW - Hippocampus/drug effects
KW - Disease Models, Animal
KW - Aging/drug effects
KW - Pyramidal Cells/drug effects
KW - Antioxidants/pharmacology
KW - Neuroprotective Agents/pharmacology
KW - CA1 Region, Hippocampal/drug effects
KW - Ceftriaxone/pharmacology
KW - Animals
KW - Cognition/drug effects
UR - http://www.scopus.com/inward/record.url?scp=85019550732&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2017.05.002
DO - 10.1016/j.bbr.2017.05.002
M3 - Article
C2 - 28487222
AN - SCOPUS:85019550732
VL - 330
SP - 8
EP - 16
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
ER -
ID: 9977270