Standard

Neurodevelopment and behavior in neonatal OXYS rats with genetically determined accelerated senescence. / Igonina, Tatyana N.; Ragaeva, Diana S.; Tikhonova, Maria A. et al.

In: Brain Research, Vol. 1681, 15.02.2018, p. 75-84.

Research output: Contribution to journalArticlepeer-review

Harvard

Igonina, TN, Ragaeva, DS, Tikhonova, MA, Petrova, OM, Herbeck, YE, Rozhkova, IN, Amstislavskaya, TG & Amstislavsky, SY 2018, 'Neurodevelopment and behavior in neonatal OXYS rats with genetically determined accelerated senescence', Brain Research, vol. 1681, pp. 75-84. https://doi.org/10.1016/j.brainres.2017.12.021

APA

Igonina, T. N., Ragaeva, D. S., Tikhonova, M. A., Petrova, O. M., Herbeck, Y. E., Rozhkova, I. N., Amstislavskaya, T. G., & Amstislavsky, S. Y. (2018). Neurodevelopment and behavior in neonatal OXYS rats with genetically determined accelerated senescence. Brain Research, 1681, 75-84. https://doi.org/10.1016/j.brainres.2017.12.021

Vancouver

Igonina TN, Ragaeva DS, Tikhonova MA, Petrova OM, Herbeck YE, Rozhkova IN et al. Neurodevelopment and behavior in neonatal OXYS rats with genetically determined accelerated senescence. Brain Research. 2018 Feb 15;1681:75-84. doi: 10.1016/j.brainres.2017.12.021

Author

Igonina, Tatyana N. ; Ragaeva, Diana S. ; Tikhonova, Maria A. et al. / Neurodevelopment and behavior in neonatal OXYS rats with genetically determined accelerated senescence. In: Brain Research. 2018 ; Vol. 1681. pp. 75-84.

BibTeX

@article{d3388423ee0a458595022d19adb155ae,
title = "Neurodevelopment and behavior in neonatal OXYS rats with genetically determined accelerated senescence",
abstract = "Study of the developmental characteristics and mechanisms of senescence is an important field in brain aging research. The OXYS strain was selected from Wistar rats in Novosibirsk, and it serves as a rat model of accelerated aging. Previously, neurodegenerative processes and aberrant behavior were reported in experiments with adult OXYS rats. In our study, neurodevelopmental reflexes, neuronal density in the prefrontal cortex and hippocampus, and global DNA methylation in the hippocampus are compared between OXYS and WAG (Wistar Albino Glaxo) neonatal pups. The development of the righting, forelimb grasp, and cliff avoidance reflexes is delayed, and body weight gain was deferred in neonatal OXYS pups. Neuronal density in the hippocampus does not differ between one-day-old OXYS and WAG pups. On the sixth day, the neuronal density in OXYS pups is reduced in the CA2 hippocampal zone, augmented in CA3 and DG, and unchanged in CA1. Six-day-old OXYS pups have fewer and smaller pyramidal neurons in the prefrontal cortex as compared to WAG controls. Global DNA methylation levels in the hippocampus of OXYS newborns are significantly lower than in the WAG newborn pups. At the age of six days, the global DNA methylation level decreases in WAG pups, but does not change in OXYS pups. Thus, neonatal OXYS rats show delayed neurodevelopment accompanied by changes in the global DNA methylation pattern in the hippocampus and in neuronal density in the hippocampus and the prefrontal cortex. These changes may be related to accelerated senescence in adult OXYS rats.",
keywords = "Global DNA methylation, Hippocampus, Neurodevelopmental reflexes, Neuronal density, OXYS rats, Prefrontal cortex, DNA METHYLATION, NEURONAL CHANGES, SPORADIC ALZHEIMERS-DISEASE, MODEL, PREFRONTAL CORTEX, MORPHOLOGICAL-CHANGES, AMD-LIKE RETINOPATHY, HUMAN HIPPOCAMPUS, TARGETED ANTIOXIDANT SKQ1, NEUROLOGICAL REFLEXES, Hippocampus/cytology, Rats, Wistar, Cell Count, Male, Behavior, Animal, DNA Methylation, Female, Animals, Newborn, Prefrontal Cortex/cytology, Reflex, Aging/genetics, Rats, Transgenic, Neurons/cytology, Animals",
author = "Igonina, {Tatyana N.} and Ragaeva, {Diana S.} and Tikhonova, {Maria A.} and Petrova, {Olga M.} and Herbeck, {Yuri E.} and Rozhkova, {Irina N.} and Amstislavskaya, {Tamara G.} and Amstislavsky, {Sergey Ya}",
note = "Publisher Copyright: {\textcopyright} 2017",
year = "2018",
month = feb,
day = "15",
doi = "10.1016/j.brainres.2017.12.021",
language = "English",
volume = "1681",
pages = "75--84",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Neurodevelopment and behavior in neonatal OXYS rats with genetically determined accelerated senescence

AU - Igonina, Tatyana N.

AU - Ragaeva, Diana S.

AU - Tikhonova, Maria A.

AU - Petrova, Olga M.

AU - Herbeck, Yuri E.

AU - Rozhkova, Irina N.

AU - Amstislavskaya, Tamara G.

AU - Amstislavsky, Sergey Ya

N1 - Publisher Copyright: © 2017

PY - 2018/2/15

Y1 - 2018/2/15

N2 - Study of the developmental characteristics and mechanisms of senescence is an important field in brain aging research. The OXYS strain was selected from Wistar rats in Novosibirsk, and it serves as a rat model of accelerated aging. Previously, neurodegenerative processes and aberrant behavior were reported in experiments with adult OXYS rats. In our study, neurodevelopmental reflexes, neuronal density in the prefrontal cortex and hippocampus, and global DNA methylation in the hippocampus are compared between OXYS and WAG (Wistar Albino Glaxo) neonatal pups. The development of the righting, forelimb grasp, and cliff avoidance reflexes is delayed, and body weight gain was deferred in neonatal OXYS pups. Neuronal density in the hippocampus does not differ between one-day-old OXYS and WAG pups. On the sixth day, the neuronal density in OXYS pups is reduced in the CA2 hippocampal zone, augmented in CA3 and DG, and unchanged in CA1. Six-day-old OXYS pups have fewer and smaller pyramidal neurons in the prefrontal cortex as compared to WAG controls. Global DNA methylation levels in the hippocampus of OXYS newborns are significantly lower than in the WAG newborn pups. At the age of six days, the global DNA methylation level decreases in WAG pups, but does not change in OXYS pups. Thus, neonatal OXYS rats show delayed neurodevelopment accompanied by changes in the global DNA methylation pattern in the hippocampus and in neuronal density in the hippocampus and the prefrontal cortex. These changes may be related to accelerated senescence in adult OXYS rats.

AB - Study of the developmental characteristics and mechanisms of senescence is an important field in brain aging research. The OXYS strain was selected from Wistar rats in Novosibirsk, and it serves as a rat model of accelerated aging. Previously, neurodegenerative processes and aberrant behavior were reported in experiments with adult OXYS rats. In our study, neurodevelopmental reflexes, neuronal density in the prefrontal cortex and hippocampus, and global DNA methylation in the hippocampus are compared between OXYS and WAG (Wistar Albino Glaxo) neonatal pups. The development of the righting, forelimb grasp, and cliff avoidance reflexes is delayed, and body weight gain was deferred in neonatal OXYS pups. Neuronal density in the hippocampus does not differ between one-day-old OXYS and WAG pups. On the sixth day, the neuronal density in OXYS pups is reduced in the CA2 hippocampal zone, augmented in CA3 and DG, and unchanged in CA1. Six-day-old OXYS pups have fewer and smaller pyramidal neurons in the prefrontal cortex as compared to WAG controls. Global DNA methylation levels in the hippocampus of OXYS newborns are significantly lower than in the WAG newborn pups. At the age of six days, the global DNA methylation level decreases in WAG pups, but does not change in OXYS pups. Thus, neonatal OXYS rats show delayed neurodevelopment accompanied by changes in the global DNA methylation pattern in the hippocampus and in neuronal density in the hippocampus and the prefrontal cortex. These changes may be related to accelerated senescence in adult OXYS rats.

KW - Global DNA methylation

KW - Hippocampus

KW - Neurodevelopmental reflexes

KW - Neuronal density

KW - OXYS rats

KW - Prefrontal cortex

KW - DNA METHYLATION

KW - NEURONAL CHANGES

KW - SPORADIC ALZHEIMERS-DISEASE

KW - MODEL

KW - PREFRONTAL CORTEX

KW - MORPHOLOGICAL-CHANGES

KW - AMD-LIKE RETINOPATHY

KW - HUMAN HIPPOCAMPUS

KW - TARGETED ANTIOXIDANT SKQ1

KW - NEUROLOGICAL REFLEXES

KW - Hippocampus/cytology

KW - Rats, Wistar

KW - Cell Count

KW - Male

KW - Behavior, Animal

KW - DNA Methylation

KW - Female

KW - Animals, Newborn

KW - Prefrontal Cortex/cytology

KW - Reflex

KW - Aging/genetics

KW - Rats, Transgenic

KW - Neurons/cytology

KW - Animals

UR - http://www.scopus.com/inward/record.url?scp=85039988102&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2017.12.021

DO - 10.1016/j.brainres.2017.12.021

M3 - Article

C2 - 29274882

AN - SCOPUS:85039988102

VL - 1681

SP - 75

EP - 84

JO - Brain Research

JF - Brain Research

SN - 0006-8993

ER -

ID: 9160000