Research output: Contribution to journal › Article › peer-review
Neurodevelopment and behavior in neonatal OXYS rats with genetically determined accelerated senescence. / Igonina, Tatyana N.; Ragaeva, Diana S.; Tikhonova, Maria A. et al.
In: Brain Research, Vol. 1681, 15.02.2018, p. 75-84.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Neurodevelopment and behavior in neonatal OXYS rats with genetically determined accelerated senescence
AU - Igonina, Tatyana N.
AU - Ragaeva, Diana S.
AU - Tikhonova, Maria A.
AU - Petrova, Olga M.
AU - Herbeck, Yuri E.
AU - Rozhkova, Irina N.
AU - Amstislavskaya, Tamara G.
AU - Amstislavsky, Sergey Ya
N1 - Publisher Copyright: © 2017
PY - 2018/2/15
Y1 - 2018/2/15
N2 - Study of the developmental characteristics and mechanisms of senescence is an important field in brain aging research. The OXYS strain was selected from Wistar rats in Novosibirsk, and it serves as a rat model of accelerated aging. Previously, neurodegenerative processes and aberrant behavior were reported in experiments with adult OXYS rats. In our study, neurodevelopmental reflexes, neuronal density in the prefrontal cortex and hippocampus, and global DNA methylation in the hippocampus are compared between OXYS and WAG (Wistar Albino Glaxo) neonatal pups. The development of the righting, forelimb grasp, and cliff avoidance reflexes is delayed, and body weight gain was deferred in neonatal OXYS pups. Neuronal density in the hippocampus does not differ between one-day-old OXYS and WAG pups. On the sixth day, the neuronal density in OXYS pups is reduced in the CA2 hippocampal zone, augmented in CA3 and DG, and unchanged in CA1. Six-day-old OXYS pups have fewer and smaller pyramidal neurons in the prefrontal cortex as compared to WAG controls. Global DNA methylation levels in the hippocampus of OXYS newborns are significantly lower than in the WAG newborn pups. At the age of six days, the global DNA methylation level decreases in WAG pups, but does not change in OXYS pups. Thus, neonatal OXYS rats show delayed neurodevelopment accompanied by changes in the global DNA methylation pattern in the hippocampus and in neuronal density in the hippocampus and the prefrontal cortex. These changes may be related to accelerated senescence in adult OXYS rats.
AB - Study of the developmental characteristics and mechanisms of senescence is an important field in brain aging research. The OXYS strain was selected from Wistar rats in Novosibirsk, and it serves as a rat model of accelerated aging. Previously, neurodegenerative processes and aberrant behavior were reported in experiments with adult OXYS rats. In our study, neurodevelopmental reflexes, neuronal density in the prefrontal cortex and hippocampus, and global DNA methylation in the hippocampus are compared between OXYS and WAG (Wistar Albino Glaxo) neonatal pups. The development of the righting, forelimb grasp, and cliff avoidance reflexes is delayed, and body weight gain was deferred in neonatal OXYS pups. Neuronal density in the hippocampus does not differ between one-day-old OXYS and WAG pups. On the sixth day, the neuronal density in OXYS pups is reduced in the CA2 hippocampal zone, augmented in CA3 and DG, and unchanged in CA1. Six-day-old OXYS pups have fewer and smaller pyramidal neurons in the prefrontal cortex as compared to WAG controls. Global DNA methylation levels in the hippocampus of OXYS newborns are significantly lower than in the WAG newborn pups. At the age of six days, the global DNA methylation level decreases in WAG pups, but does not change in OXYS pups. Thus, neonatal OXYS rats show delayed neurodevelopment accompanied by changes in the global DNA methylation pattern in the hippocampus and in neuronal density in the hippocampus and the prefrontal cortex. These changes may be related to accelerated senescence in adult OXYS rats.
KW - Global DNA methylation
KW - Hippocampus
KW - Neurodevelopmental reflexes
KW - Neuronal density
KW - OXYS rats
KW - Prefrontal cortex
KW - DNA METHYLATION
KW - NEURONAL CHANGES
KW - SPORADIC ALZHEIMERS-DISEASE
KW - MODEL
KW - PREFRONTAL CORTEX
KW - MORPHOLOGICAL-CHANGES
KW - AMD-LIKE RETINOPATHY
KW - HUMAN HIPPOCAMPUS
KW - TARGETED ANTIOXIDANT SKQ1
KW - NEUROLOGICAL REFLEXES
KW - Hippocampus/cytology
KW - Rats, Wistar
KW - Cell Count
KW - Male
KW - Behavior, Animal
KW - DNA Methylation
KW - Female
KW - Animals, Newborn
KW - Prefrontal Cortex/cytology
KW - Reflex
KW - Aging/genetics
KW - Rats, Transgenic
KW - Neurons/cytology
KW - Animals
UR - http://www.scopus.com/inward/record.url?scp=85039988102&partnerID=8YFLogxK
U2 - 10.1016/j.brainres.2017.12.021
DO - 10.1016/j.brainres.2017.12.021
M3 - Article
C2 - 29274882
AN - SCOPUS:85039988102
VL - 1681
SP - 75
EP - 84
JO - Brain Research
JF - Brain Research
SN - 0006-8993
ER -
ID: 9160000