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Neurochemical Markers of Efficacy of Selective Serotonin Reuptake Inhibitors and Resveratrol in Correcting Anxiety Disorders of Stressful Nature. / Tseilikman, V. E.; Tseilikman, O. B.; Shatilov, V. A. et al.

In: Neurochemical Journal, Vol. 19, No. 1, 2025, p. 60-73.

Research output: Contribution to journal › Article › peer-review

Harvard

Tseilikman, VE, Tseilikman, OB, Shatilov, VA, Manuilov, GV, Egorov, ON, Zhukov, MS, Aristov, MR, Epitashvili, AE, Tseylikman, D-MV, Buksha, IA, Lipatov, IA, Shamshurin, MV, Shonina, AK, Shevyrin, VA, Kolesnikova, AS & Brichagina, AA 2025, 'Neurochemical Markers of Efficacy of Selective Serotonin Reuptake Inhibitors and Resveratrol in Correcting Anxiety Disorders of Stressful Nature', Neurochemical Journal, vol. 19, no. 1, pp. 60-73. https://doi.org/10.1134/s1819712425700084

APA

Tseilikman, V. E., Tseilikman, O. B., Shatilov, V. A., Manuilov, G. V., Egorov, O. N., Zhukov, M. S., Aristov, M. R., Epitashvili, A. E., Tseylikman, D-M. V., Buksha, I. A., Lipatov, I. A., Shamshurin, M. V., Shonina, A. K., Shevyrin, V. A., Kolesnikova, A. S., & Brichagina, A. A. (2025). Neurochemical Markers of Efficacy of Selective Serotonin Reuptake Inhibitors and Resveratrol in Correcting Anxiety Disorders of Stressful Nature. Neurochemical Journal, 19(1), 60-73. https://doi.org/10.1134/s1819712425700084

Vancouver

Tseilikman VE, Tseilikman OB, Shatilov VA, Manuilov GV, Egorov ON, Zhukov MS et al. Neurochemical Markers of Efficacy of Selective Serotonin Reuptake Inhibitors and Resveratrol in Correcting Anxiety Disorders of Stressful Nature. Neurochemical Journal. 2025;19(1):60-73. doi: 10.1134/s1819712425700084

Author

Tseilikman, V. E. ; Tseilikman, O. B. ; Shatilov, V. A. et al. / Neurochemical Markers of Efficacy of Selective Serotonin Reuptake Inhibitors and Resveratrol in Correcting Anxiety Disorders of Stressful Nature. In: Neurochemical Journal. 2025 ; Vol. 19, No. 1. pp. 60-73.

BibTeX

@article{dab99cbfaf674013b0b84602ee99b0b4,
title = "Neurochemical Markers of Efficacy of Selective Serotonin Reuptake Inhibitors and Resveratrol in Correcting Anxiety Disorders of Stressful Nature",
abstract = "Anxiety-phobic disorders are behavioral complications of chronic stress. Unfortunately, there is still no effective pharmacological correction of them. The aim of the study was to assess the prospect of the combined use of resveratrol and selective serotonin reuptake inhibitors for the correction of anxiety-phobic disorders caused by chronic predatory stress. To reproduce anxiety-phobic disorders, we used a model of predatory stress caused by contact of rats with the smell of a fox. The anxiety level was determined in the elevated plus maze test. In the cerebral cortex, the content of serotonin, MAO-A, activity and the intensity of lipid peroxidation (LPO) were determined. It was found that chronic predatory stress was accompanied by an increase in anxiety, manifested in a decrease in the time spent in the open arms of the plus maze and increased freezing. At the same time, serotonin levels and MAO-A activity increased in the brain, and the intensity of lipid peroxidation increased. Fluoxetine and citalopram alone did not effectively correct anxiety-phobic disorders. Resveratrol alone and together with fluoxetine and citalopram either weakened or enhanced anxiety-phobic disorders. The effects of resveratrol were dose-dependent. A decrease in stress anxiety as a result of pharmacological correction was accompanied by a restoration of serotonin levels to control values, a decrease in MAO-A activity and the LPO intensity in the brain. Resveratrol, both independently and in the presence of selective serotonin reuptake inhibitors, can effectively correct anxiety-phobic disorders in some cases and potentiate in others depending on the dose.",
keywords = "ANXIETY-PHOBIC DISORDERS, RESVERATROL, PREDATORY STRESS, CITALOPRAM, FLUOXETINE, SEROTONIN, LPO, MAO",
author = "Tseilikman, {V. E.} and Tseilikman, {O. B.} and Shatilov, {V. A.} and Manuilov, {G. V.} and Egorov, {O. N.} and Zhukov, {M. S.} and Aristov, {M. R.} and Epitashvili, {A. E.} and Tseylikman, {D.-M. V.} and Buksha, {I. A.} and Lipatov, {I. A.} and Shamshurin, {M. V.} and Shonina, {A. K.} and Shevyrin, {V. A.} and Kolesnikova, {A. S.} and Brichagina, {A. A.}",
note = "The study was supported by a regional grant from the Russian Science Foundation, Chelyabinsk Region, project no. 23-15-20040. Neurochemical Markers of Efficacy of Selective Serotonin Reuptake Inhibitors and Resveratrol in Correcting Anxiety Disorders of Stressful Nature / V. E. Tseilikman, O. B. Tseilikman, V. A. Shatilov [et al.] // Neurochemical Journal. – 2025. – Vol. 19, No. 1. – P. 60-73. – DOI 10.1134/S1819712425700084. ",
year = "2025",
doi = "10.1134/s1819712425700084",
language = "English",
volume = "19",
pages = "60--73",
journal = "Neurochemical Journal",
issn = "1819-7124",
publisher = "Общество с ограниченной ответственностью Международная академическая издательская компания {"}Наука/Интерпериодика{"}",
number = "1",

}

RIS

TY - JOUR

T1 - Neurochemical Markers of Efficacy of Selective Serotonin Reuptake Inhibitors and Resveratrol in Correcting Anxiety Disorders of Stressful Nature

AU - Tseilikman, V. E.

AU - Tseilikman, O. B.

AU - Shatilov, V. A.

AU - Manuilov, G. V.

AU - Egorov, O. N.

AU - Zhukov, M. S.

AU - Aristov, M. R.

AU - Epitashvili, A. E.

AU - Tseylikman, D.-M. V.

AU - Buksha, I. A.

AU - Lipatov, I. A.

AU - Shamshurin, M. V.

AU - Shonina, A. K.

AU - Shevyrin, V. A.

AU - Kolesnikova, A. S.

AU - Brichagina, A. A.

N1 - The study was supported by a regional grant from the Russian Science Foundation, Chelyabinsk Region, project no. 23-15-20040. Neurochemical Markers of Efficacy of Selective Serotonin Reuptake Inhibitors and Resveratrol in Correcting Anxiety Disorders of Stressful Nature / V. E. Tseilikman, O. B. Tseilikman, V. A. Shatilov [et al.] // Neurochemical Journal. – 2025. – Vol. 19, No. 1. – P. 60-73. – DOI 10.1134/S1819712425700084.

PY - 2025

Y1 - 2025

N2 - Anxiety-phobic disorders are behavioral complications of chronic stress. Unfortunately, there is still no effective pharmacological correction of them. The aim of the study was to assess the prospect of the combined use of resveratrol and selective serotonin reuptake inhibitors for the correction of anxiety-phobic disorders caused by chronic predatory stress. To reproduce anxiety-phobic disorders, we used a model of predatory stress caused by contact of rats with the smell of a fox. The anxiety level was determined in the elevated plus maze test. In the cerebral cortex, the content of serotonin, MAO-A, activity and the intensity of lipid peroxidation (LPO) were determined. It was found that chronic predatory stress was accompanied by an increase in anxiety, manifested in a decrease in the time spent in the open arms of the plus maze and increased freezing. At the same time, serotonin levels and MAO-A activity increased in the brain, and the intensity of lipid peroxidation increased. Fluoxetine and citalopram alone did not effectively correct anxiety-phobic disorders. Resveratrol alone and together with fluoxetine and citalopram either weakened or enhanced anxiety-phobic disorders. The effects of resveratrol were dose-dependent. A decrease in stress anxiety as a result of pharmacological correction was accompanied by a restoration of serotonin levels to control values, a decrease in MAO-A activity and the LPO intensity in the brain. Resveratrol, both independently and in the presence of selective serotonin reuptake inhibitors, can effectively correct anxiety-phobic disorders in some cases and potentiate in others depending on the dose.

AB - Anxiety-phobic disorders are behavioral complications of chronic stress. Unfortunately, there is still no effective pharmacological correction of them. The aim of the study was to assess the prospect of the combined use of resveratrol and selective serotonin reuptake inhibitors for the correction of anxiety-phobic disorders caused by chronic predatory stress. To reproduce anxiety-phobic disorders, we used a model of predatory stress caused by contact of rats with the smell of a fox. The anxiety level was determined in the elevated plus maze test. In the cerebral cortex, the content of serotonin, MAO-A, activity and the intensity of lipid peroxidation (LPO) were determined. It was found that chronic predatory stress was accompanied by an increase in anxiety, manifested in a decrease in the time spent in the open arms of the plus maze and increased freezing. At the same time, serotonin levels and MAO-A activity increased in the brain, and the intensity of lipid peroxidation increased. Fluoxetine and citalopram alone did not effectively correct anxiety-phobic disorders. Resveratrol alone and together with fluoxetine and citalopram either weakened or enhanced anxiety-phobic disorders. The effects of resveratrol were dose-dependent. A decrease in stress anxiety as a result of pharmacological correction was accompanied by a restoration of serotonin levels to control values, a decrease in MAO-A activity and the LPO intensity in the brain. Resveratrol, both independently and in the presence of selective serotonin reuptake inhibitors, can effectively correct anxiety-phobic disorders in some cases and potentiate in others depending on the dose.

KW - ANXIETY-PHOBIC DISORDERS

KW - RESVERATROL

KW - PREDATORY STRESS

KW - CITALOPRAM

KW - FLUOXETINE

KW - SEROTONIN

KW - LPO

KW - MAO

UR - https://www.mendeley.com/catalogue/f8e60739-d374-3e9c-9e30-fd70054c7f7a/

UR - https://elibrary.ru/item.asp?id=82620998

U2 - 10.1134/s1819712425700084

DO - 10.1134/s1819712425700084

M3 - Article

VL - 19

SP - 60

EP - 73

JO - Neurochemical Journal

JF - Neurochemical Journal

SN - 1819-7124

IS - 1

ER -

ID: 71564698