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Naked mole rat cells display more efficient DNA excision repair and higher resistance to toxic impacts than mouse cells. / Evdokimov, Alexey; Petruseva, Irina; Popov, Aleksei et al.

INTERNATIONAL CONFERENCE LONGEVITY INTERVENTIONS 2020 (ICLI 2020). ed. / O Kovtun; Bazarnyi. University of Lueneburg, Department of Economics and Social Sciences, Research Institute on Professions, 2020. 01017 (BIO Web of Conferences; Vol. 22).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review

Harvard

Evdokimov, A, Petruseva, I, Popov, A, Koval, O & Lavrik, O 2020, Naked mole rat cells display more efficient DNA excision repair and higher resistance to toxic impacts than mouse cells. in O Kovtun & Bazarnyi (eds), INTERNATIONAL CONFERENCE LONGEVITY INTERVENTIONS 2020 (ICLI 2020)., 01017, BIO Web of Conferences, vol. 22, University of Lueneburg, Department of Economics and Social Sciences, Research Institute on Professions, International Scientific Conference on Longevity Interventions (ICLI), Ekaterinburg, 20.04.2020. https://doi.org/10.1051/bioconf/20202201017

APA

Evdokimov, A., Petruseva, I., Popov, A., Koval, O., & Lavrik, O. (2020). Naked mole rat cells display more efficient DNA excision repair and higher resistance to toxic impacts than mouse cells. In O. Kovtun, & Bazarnyi (Eds.), INTERNATIONAL CONFERENCE LONGEVITY INTERVENTIONS 2020 (ICLI 2020) [01017] (BIO Web of Conferences; Vol. 22). University of Lueneburg, Department of Economics and Social Sciences, Research Institute on Professions. https://doi.org/10.1051/bioconf/20202201017

Vancouver

Evdokimov A, Petruseva I, Popov A, Koval O, Lavrik O. Naked mole rat cells display more efficient DNA excision repair and higher resistance to toxic impacts than mouse cells. In Kovtun O, Bazarnyi, editors, INTERNATIONAL CONFERENCE LONGEVITY INTERVENTIONS 2020 (ICLI 2020). University of Lueneburg, Department of Economics and Social Sciences, Research Institute on Professions. 2020. 01017. (BIO Web of Conferences). doi: 10.1051/bioconf/20202201017

Author

Evdokimov, Alexey ; Petruseva, Irina ; Popov, Aleksei et al. / Naked mole rat cells display more efficient DNA excision repair and higher resistance to toxic impacts than mouse cells. INTERNATIONAL CONFERENCE LONGEVITY INTERVENTIONS 2020 (ICLI 2020). editor / O Kovtun ; Bazarnyi. University of Lueneburg, Department of Economics and Social Sciences, Research Institute on Professions, 2020. (BIO Web of Conferences).

BibTeX

@inproceedings{990ba76dc66a41f795976b9381638dfb,
title = "Naked mole rat cells display more efficient DNA excision repair and higher resistance to toxic impacts than mouse cells",
abstract = "Naked mole rat is the long-lived and tumor-resistant rodent. Naked mole rat possesses multiple adaptations that may contribute to longevity and cancer-resistance. Higher activity of DNA excision repair systems and their faster recovery after genotoxic impact as compare with Mus musculus directly demonstrated in our previous investigation contribute to longevity and cancer resistance of naked mole rat. In the present study the DNA-damage-induced apoptosis in naked mole rat fibroblasts was studied using conventional methods. The ability of naked mole rat cells to undergo regulated cell death in response to genotoxic stress is another group of cell defense mechanisms. Naked mole rat skin fibroblasts were demonstrated to be much more resistant towards proapoptotic reagents methyl methanesulfonate, 5-fluorouracil and etoposide as compared with fibroblasts of Mus musculus. Naked mole rat cells have demonstrated limited apoptotic response and seem to undergo also other-type regulated cell death under severe genotoxic stress.",
keywords = "LONGEVITY, RODENT",
author = "Alexey Evdokimov and Irina Petruseva and Aleksei Popov and Olga Koval and Olga Lavrik",
year = "2020",
doi = "10.1051/bioconf/20202201017",
language = "English",
series = "BIO Web of Conferences",
publisher = "University of Lueneburg, Department of Economics and Social Sciences, Research Institute on Professions",
editor = "O Kovtun and Bazarnyi",
booktitle = "INTERNATIONAL CONFERENCE LONGEVITY INTERVENTIONS 2020 (ICLI 2020)",
address = "Germany",
note = "International Scientific Conference on Longevity Interventions (ICLI) ; Conference date: 20-04-2020 Through 22-04-2020",

}

RIS

TY - GEN

T1 - Naked mole rat cells display more efficient DNA excision repair and higher resistance to toxic impacts than mouse cells

AU - Evdokimov, Alexey

AU - Petruseva, Irina

AU - Popov, Aleksei

AU - Koval, Olga

AU - Lavrik, Olga

PY - 2020

Y1 - 2020

N2 - Naked mole rat is the long-lived and tumor-resistant rodent. Naked mole rat possesses multiple adaptations that may contribute to longevity and cancer-resistance. Higher activity of DNA excision repair systems and their faster recovery after genotoxic impact as compare with Mus musculus directly demonstrated in our previous investigation contribute to longevity and cancer resistance of naked mole rat. In the present study the DNA-damage-induced apoptosis in naked mole rat fibroblasts was studied using conventional methods. The ability of naked mole rat cells to undergo regulated cell death in response to genotoxic stress is another group of cell defense mechanisms. Naked mole rat skin fibroblasts were demonstrated to be much more resistant towards proapoptotic reagents methyl methanesulfonate, 5-fluorouracil and etoposide as compared with fibroblasts of Mus musculus. Naked mole rat cells have demonstrated limited apoptotic response and seem to undergo also other-type regulated cell death under severe genotoxic stress.

AB - Naked mole rat is the long-lived and tumor-resistant rodent. Naked mole rat possesses multiple adaptations that may contribute to longevity and cancer-resistance. Higher activity of DNA excision repair systems and their faster recovery after genotoxic impact as compare with Mus musculus directly demonstrated in our previous investigation contribute to longevity and cancer resistance of naked mole rat. In the present study the DNA-damage-induced apoptosis in naked mole rat fibroblasts was studied using conventional methods. The ability of naked mole rat cells to undergo regulated cell death in response to genotoxic stress is another group of cell defense mechanisms. Naked mole rat skin fibroblasts were demonstrated to be much more resistant towards proapoptotic reagents methyl methanesulfonate, 5-fluorouracil and etoposide as compared with fibroblasts of Mus musculus. Naked mole rat cells have demonstrated limited apoptotic response and seem to undergo also other-type regulated cell death under severe genotoxic stress.

KW - LONGEVITY

KW - RODENT

U2 - 10.1051/bioconf/20202201017

DO - 10.1051/bioconf/20202201017

M3 - Conference contribution

T3 - BIO Web of Conferences

BT - INTERNATIONAL CONFERENCE LONGEVITY INTERVENTIONS 2020 (ICLI 2020)

A2 - Kovtun, O

A2 - Bazarnyi, null

PB - University of Lueneburg, Department of Economics and Social Sciences, Research Institute on Professions

T2 - International Scientific Conference on Longevity Interventions (ICLI)

Y2 - 20 April 2020 through 22 April 2020

ER -

ID: 27958251