TY - JOUR

T1 - Multifunctional Nanotheranostics for Overcoming the Blood–Brain Barrier

AU - Beygi, Mohammad

AU - Oroojalian, Fatemeh

AU - Azizi-Arani, Soheil

AU - Hosseini, Seyed Samad

AU - Mokhtarzadeh, Ahad

AU - Kesharwani, Prashant

AU - Sahebkar, Amirhossein

N1 - The authors are grateful for financial support from the Immunology Research Center, Tabriz University of Medical Sciences (TUMS; Tabriz, Iran) and North Khorasan University of Medical Sciences (NKUMS; Bojnurd, Iran). Публикация для коррекировки.

PY - 2024/5/10

Y1 - 2024/5/10

N2 - The blood–brain barrier (BBB) is a tailored system of capillary endothelial cells intermixed with tight junctions and adherent junctions that regulates the transport of various materials and substances between the blood vasculature and the central nervous system (CNS). However, in cases of brain diseases, BBB's protective and regulatory effects hamper therapeutics from reaching affected sites in sufficient quantities. This has so far been a leading challenge in treating CNS diseases and disorders. For this problem to be overcome, recent research has sought to develop novel modalities to achieve efficient therapy and alleviate associated symptoms. Therefore, numerous strategies have operated in recent years to address the limitations of traditional and invasive methods, including poor brain penetration and serious side effects. As a desperately in-demand technology, nanotheranostics has particularly shown promising results. Herein, this review reports recent advancements in CNS nanotheranostics and novel techniques and nanotechnology-based strategies developed for treating neurodegenerative disorders. The study provides comprehensive data on the subject to be used for future studies for the therapy and management of CNS disorders and diseases.

AB - The blood–brain barrier (BBB) is a tailored system of capillary endothelial cells intermixed with tight junctions and adherent junctions that regulates the transport of various materials and substances between the blood vasculature and the central nervous system (CNS). However, in cases of brain diseases, BBB's protective and regulatory effects hamper therapeutics from reaching affected sites in sufficient quantities. This has so far been a leading challenge in treating CNS diseases and disorders. For this problem to be overcome, recent research has sought to develop novel modalities to achieve efficient therapy and alleviate associated symptoms. Therefore, numerous strategies have operated in recent years to address the limitations of traditional and invasive methods, including poor brain penetration and serious side effects. As a desperately in-demand technology, nanotheranostics has particularly shown promising results. Herein, this review reports recent advancements in CNS nanotheranostics and novel techniques and nanotechnology-based strategies developed for treating neurodegenerative disorders. The study provides comprehensive data on the subject to be used for future studies for the therapy and management of CNS disorders and diseases.

KW - CNS disorders

KW - blood–brain barrier

KW - drug delivery

KW - multifunctional nanotheranostics

KW - nanotechnology

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85181446265&origin=inward&txGid=87aad1cbda6e7e7ae9c5d70b48ea9923

UR - https://www.mendeley.com/catalogue/d40ee07a-0279-318d-a171-ea4525809d9c/

U2 - 10.1002/adfm.202310881

DO - 10.1002/adfm.202310881

M3 - Article

VL - 34

JO - Advanced Functional Materials

JF - Advanced Functional Materials

SN - 1616-301X

IS - 19

M1 - 2310881

ER -