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Motor-related white matter tracts are prominently affected in primary trigeminal neuralgia. / Pashkov, Anton; Filimonova, Elena; He, Jianzhong et al.

In: Clinical Neurology and Neurosurgery, Vol. 270, 11.2026, p. 109601.

Research output: Contribution to journal › Article › peer-review

Harvard

Pashkov, A, Filimonova, E, He, J, Feng, Y, Moysak, G & Rzaev, J 2026, 'Motor-related white matter tracts are prominently affected in primary trigeminal neuralgia', Clinical Neurology and Neurosurgery, vol. 270, pp. 109601. https://doi.org/10.1016/j.clineuro.2026.109601

APA

Pashkov, A., Filimonova, E., He, J., Feng, Y., Moysak, G., & Rzaev, J. (2026). Motor-related white matter tracts are prominently affected in primary trigeminal neuralgia. Clinical Neurology and Neurosurgery, 270, 109601. https://doi.org/10.1016/j.clineuro.2026.109601

Vancouver

Pashkov A, Filimonova E, He J, Feng Y, Moysak G, Rzaev J. Motor-related white matter tracts are prominently affected in primary trigeminal neuralgia. Clinical Neurology and Neurosurgery. 2026 Nov;270:109601. doi: 10.1016/j.clineuro.2026.109601

Author

Pashkov, Anton ; Filimonova, Elena ; He, Jianzhong et al. / Motor-related white matter tracts are prominently affected in primary trigeminal neuralgia. In: Clinical Neurology and Neurosurgery. 2026 ; Vol. 270. pp. 109601.

BibTeX

@article{ffd6c5d692a448f390c6a031491872df,
title = "Motor-related white matter tracts are prominently affected in primary trigeminal neuralgia",
abstract = "BACKGROUND: Primary trigeminal neuralgia (PTN) is a severe chronic pain disorder, yet whole-brain white matter microstructural alterations beyond the trigeminal nerve remain poorly understood, partly due to limitations of conventional diffusion tensor imaging in crossing fiber regions.METHODS: We prospectively enrolled 57 patients with classical PTN and 29 age‑ and sex-matched healthy controls. Seventy-two whole‑brain white matter tracts were reconstructed using constrained spherical deconvolution and fixel-based analysis. Fractional anisotropy (FA) was compared between groups using permutation testing with false discovery rate correction. Additional analyses examined associations with clinical variables, surgical outcomes, and neurovascular conflict status.RESULTS: Six tracts showed significantly reduced FA in PTN patients compared to controls (all p < 0.05, FDR-corrected). All six belong to motor-related systems: right fronto-pontine tract, left corticospinal tract, and four striatal tracts (right striato-prefrontal, right striato-fronto-orbital, right striato-occipital, left striato-parietal). No significant correlations with pain severity or disease duration survived multiple comparisons.CONCLUSIONS: Microstructural white matter alterations in PTN are not limited to sensory trigeminal pathways but prominently involve motor-associated striato-cortical and corticofugal projection tracts, suggesting that motor system reorganization may be one of the core features of PTN pathophysiology.",
keywords = "Primary trigeminal neuralgia, White matter, Neuroimaging, Motor system, MR tractography, Первичная тригеминальная невралгия, Белое вещество, Нейровизуализация, Моторная система, МР-трактография",
author = "Anton Pashkov and Elena Filimonova and Jianzhong He and Yuanjing Feng and Galina Moysak and Jamil Rzaev",
note = "Anton Pashkov, Elena Filimonova, Jianzhong He, Yuanjing Feng, Galina Moysak, Jamil Rzaev, Motor-related white matter tracts are prominently affected in primary trigeminal neuralgia, Clinical Neurology and Neurosurgery, Volume 270, 2026, 109601, ISSN 0303-8467, https://doi.org/10.1016/j.clineuro.2026.109601.",
year = "2026",
month = nov,
doi = "10.1016/j.clineuro.2026.109601",
language = "English",
volume = "270",
pages = "109601",
journal = "Clinical Neurology and Neurosurgery",
issn = "0303-8467",
publisher = "Elsevier Science Publishing Company, Inc.",

}

RIS

TY - JOUR

T1 - Motor-related white matter tracts are prominently affected in primary trigeminal neuralgia

AU - Pashkov, Anton

AU - Filimonova, Elena

AU - He, Jianzhong

AU - Feng, Yuanjing

AU - Moysak, Galina

AU - Rzaev, Jamil

N1 - Anton Pashkov, Elena Filimonova, Jianzhong He, Yuanjing Feng, Galina Moysak, Jamil Rzaev, Motor-related white matter tracts are prominently affected in primary trigeminal neuralgia, Clinical Neurology and Neurosurgery, Volume 270, 2026, 109601, ISSN 0303-8467, https://doi.org/10.1016/j.clineuro.2026.109601.

PY - 2026/11

Y1 - 2026/11

N2 - BACKGROUND: Primary trigeminal neuralgia (PTN) is a severe chronic pain disorder, yet whole-brain white matter microstructural alterations beyond the trigeminal nerve remain poorly understood, partly due to limitations of conventional diffusion tensor imaging in crossing fiber regions.METHODS: We prospectively enrolled 57 patients with classical PTN and 29 age‑ and sex-matched healthy controls. Seventy-two whole‑brain white matter tracts were reconstructed using constrained spherical deconvolution and fixel-based analysis. Fractional anisotropy (FA) was compared between groups using permutation testing with false discovery rate correction. Additional analyses examined associations with clinical variables, surgical outcomes, and neurovascular conflict status.RESULTS: Six tracts showed significantly reduced FA in PTN patients compared to controls (all p < 0.05, FDR-corrected). All six belong to motor-related systems: right fronto-pontine tract, left corticospinal tract, and four striatal tracts (right striato-prefrontal, right striato-fronto-orbital, right striato-occipital, left striato-parietal). No significant correlations with pain severity or disease duration survived multiple comparisons.CONCLUSIONS: Microstructural white matter alterations in PTN are not limited to sensory trigeminal pathways but prominently involve motor-associated striato-cortical and corticofugal projection tracts, suggesting that motor system reorganization may be one of the core features of PTN pathophysiology.

AB - BACKGROUND: Primary trigeminal neuralgia (PTN) is a severe chronic pain disorder, yet whole-brain white matter microstructural alterations beyond the trigeminal nerve remain poorly understood, partly due to limitations of conventional diffusion tensor imaging in crossing fiber regions.METHODS: We prospectively enrolled 57 patients with classical PTN and 29 age‑ and sex-matched healthy controls. Seventy-two whole‑brain white matter tracts were reconstructed using constrained spherical deconvolution and fixel-based analysis. Fractional anisotropy (FA) was compared between groups using permutation testing with false discovery rate correction. Additional analyses examined associations with clinical variables, surgical outcomes, and neurovascular conflict status.RESULTS: Six tracts showed significantly reduced FA in PTN patients compared to controls (all p < 0.05, FDR-corrected). All six belong to motor-related systems: right fronto-pontine tract, left corticospinal tract, and four striatal tracts (right striato-prefrontal, right striato-fronto-orbital, right striato-occipital, left striato-parietal). No significant correlations with pain severity or disease duration survived multiple comparisons.CONCLUSIONS: Microstructural white matter alterations in PTN are not limited to sensory trigeminal pathways but prominently involve motor-associated striato-cortical and corticofugal projection tracts, suggesting that motor system reorganization may be one of the core features of PTN pathophysiology.

KW - Primary trigeminal neuralgia

KW - White matter

KW - Neuroimaging

KW - Motor system

KW - MR tractography

KW - Первичная тригеминальная невралгия

KW - Белое вещество

KW - Нейровизуализация

KW - Моторная система

KW - МР-трактография

UR - https://www.scopus.com/pages/publications/105046503608

U2 - 10.1016/j.clineuro.2026.109601

DO - 10.1016/j.clineuro.2026.109601

M3 - Article

C2 - 42551242

VL - 270

SP - 109601

JO - Clinical Neurology and Neurosurgery

JF - Clinical Neurology and Neurosurgery

SN - 0303-8467

ER -

ID: 82777679