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Morphological Analysis of Blood Capillaries and Transport Function of Endothelial Cells in Hepatocellular Carcinoma-29. / Taskaeva, Yu S.; Makarova, V. V.; Gogaeva, I. S. et al.

In: Bulletin of Experimental Biology and Medicine, Vol. 169, No. 2, 01.06.2020, p. 276-280.

Research output: Contribution to journal › Article › peer-review

Harvard

Taskaeva, YS, Makarova, VV, Gogaeva, IS & Bgatova, NP 2020, 'Morphological Analysis of Blood Capillaries and Transport Function of Endothelial Cells in Hepatocellular Carcinoma-29', Bulletin of Experimental Biology and Medicine, vol. 169, no. 2, pp. 276-280. https://doi.org/10.1007/s10517-020-04867-w

APA

Taskaeva, Y. S., Makarova, V. V., Gogaeva, I. S., & Bgatova, N. P. (2020). Morphological Analysis of Blood Capillaries and Transport Function of Endothelial Cells in Hepatocellular Carcinoma-29. Bulletin of Experimental Biology and Medicine, 169(2), 276-280. https://doi.org/10.1007/s10517-020-04867-w

Vancouver

Taskaeva YS, Makarova VV, Gogaeva IS, Bgatova NP. Morphological Analysis of Blood Capillaries and Transport Function of Endothelial Cells in Hepatocellular Carcinoma-29. Bulletin of Experimental Biology and Medicine. 2020 Jun 1;169(2):276-280. doi: 10.1007/s10517-020-04867-w

Author

Taskaeva, Yu S. ; Makarova, V. V. ; Gogaeva, I. S. et al. / Morphological Analysis of Blood Capillaries and Transport Function of Endothelial Cells in Hepatocellular Carcinoma-29. In: Bulletin of Experimental Biology and Medicine. 2020 ; Vol. 169, No. 2. pp. 276-280.

BibTeX

@article{3658a87b77074ee2af568c1ceb81f6df,
title = "Morphological Analysis of Blood Capillaries and Transport Function of Endothelial Cells in Hepatocellular Carcinoma-29",
abstract = "Hepatocellular carcinoma is characterized by the pronounced vascularization, high levels of vascular endothelial growth factors, and intensive angiogenesis. Caveola-mediated endocytosis and clathrin-dependent endocytosis contribute to internalization of various growth factors, thus affecting blood supply to the tumor and neoangiogenesis. We performed a quantitative analysis of blood vessels in the tumor and evaluated the basal levels of endocytosis-associated vesicular structures in the endothelial cells of the hepatocellular carcinoma-29. The numbers of blood vessels and clathrin-coated vesicles in endothelial cells in the tumor tissue were significantly higher than in normal tissue. The association between clathrin-dependent endocytosis in the endotheliocytes of the capillaries and tumor angiogenesis can provide the basis for the development of new molecular targets for antiangiogenic antitumor therapy.",
keywords = "angiogenesis, endocytosis, endothelial cell, hepatocellular carcinoma, ultrastructural organization",
author = "Taskaeva, {Yu S.} and Makarova, {V. V.} and Gogaeva, {I. S.} and Bgatova, {N. P.}",
year = "2020",
month = jun,
day = "1",
doi = "10.1007/s10517-020-04867-w",
language = "English",
volume = "169",
pages = "276--280",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "2",

}

RIS

TY - JOUR

T1 - Morphological Analysis of Blood Capillaries and Transport Function of Endothelial Cells in Hepatocellular Carcinoma-29

AU - Taskaeva, Yu S.

AU - Makarova, V. V.

AU - Gogaeva, I. S.

AU - Bgatova, N. P.

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Hepatocellular carcinoma is characterized by the pronounced vascularization, high levels of vascular endothelial growth factors, and intensive angiogenesis. Caveola-mediated endocytosis and clathrin-dependent endocytosis contribute to internalization of various growth factors, thus affecting blood supply to the tumor and neoangiogenesis. We performed a quantitative analysis of blood vessels in the tumor and evaluated the basal levels of endocytosis-associated vesicular structures in the endothelial cells of the hepatocellular carcinoma-29. The numbers of blood vessels and clathrin-coated vesicles in endothelial cells in the tumor tissue were significantly higher than in normal tissue. The association between clathrin-dependent endocytosis in the endotheliocytes of the capillaries and tumor angiogenesis can provide the basis for the development of new molecular targets for antiangiogenic antitumor therapy.

AB - Hepatocellular carcinoma is characterized by the pronounced vascularization, high levels of vascular endothelial growth factors, and intensive angiogenesis. Caveola-mediated endocytosis and clathrin-dependent endocytosis contribute to internalization of various growth factors, thus affecting blood supply to the tumor and neoangiogenesis. We performed a quantitative analysis of blood vessels in the tumor and evaluated the basal levels of endocytosis-associated vesicular structures in the endothelial cells of the hepatocellular carcinoma-29. The numbers of blood vessels and clathrin-coated vesicles in endothelial cells in the tumor tissue were significantly higher than in normal tissue. The association between clathrin-dependent endocytosis in the endotheliocytes of the capillaries and tumor angiogenesis can provide the basis for the development of new molecular targets for antiangiogenic antitumor therapy.

KW - angiogenesis

KW - endocytosis

KW - endothelial cell

KW - hepatocellular carcinoma

KW - ultrastructural organization

UR - http://www.scopus.com/inward/record.url?scp=85087691934&partnerID=8YFLogxK

U2 - 10.1007/s10517-020-04867-w

DO - 10.1007/s10517-020-04867-w

M3 - Article

C2 - 32651829

AN - SCOPUS:85087691934

VL - 169

SP - 276

EP - 280

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 2

ER -

ID: 24769647