Monitoring the reaction of the body state to antibiotic treatment against helicobacter pylori via infrared spectroscopy: A case study

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Monitoring the reaction of the body state to antibiotic treatment against helicobacter pylori via infrared spectroscopy: A case study. / Maiti, Kiran Sankar; Apolonski, Alexander.

In: Molecules, Vol. 26, No. 11, 3474, 01.06.2021.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{53762fe449f642d28a0ec7f415275795,

title = "Monitoring the reaction of the body state to antibiotic treatment against helicobacter pylori via infrared spectroscopy: A case study",

abstract = "The current understanding of deviations of human microbiota caused by antibiotic treatment is poor. In an attempt to improve it, a proof-of-principle spectroscopic study of the breath of one volunteer affected by a course of antibiotics for Helicobacter pylori eradication was performed. Fourier transform spectroscopy enabled searching for the absorption spectral structures sensitive to the treatment in the entire mid-infrared region. Two spectral ranges were found where the corresponding structures strongly correlated with the beginning and end of the treatment. The structures were identified as methyl ester of butyric acid and ethyl ester of pyruvic acid. Both acids generated by bacteria in the gut are involved in fundamental processes of human metabolism. Being confirmed by other studies, measurement of the methyl butyrate deviation could be a promising way for monitoring acute gastritis and anti-Helicobacter pylori antibiotic treatment.",

keywords = "Acute gastritis, Alpha-keto acid, Antibiotic treatment, Breath, Helicobacter pylori, Metabolites, Mid-infrared spectroscopy, Short-chain fatty acid, Treatment dynamics: microbiota, Volatile organic compound, Helicobacter Infections/drug therapy, Anti-Bacterial Agents/chemistry, Humans, Middle Aged, Spectrophotometry, Infrared/methods, Male, Gastritis/drug therapy, Helicobacter pylori/drug effects, Gastrointestinal Microbiome/drug effects, Butyric Acid/chemistry, Pyruvic Acid/chemistry, Esters/chemistry",

author = "Maiti, {Kiran Sankar} and Alexander Apolonski",

note = "Funding Information: Munich Center for Advanced Photonics (MAP). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = jun,

day = "1",

doi = "10.3390/molecules26113474",

language = "English",

volume = "26",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "11",

}

RIS

TY - JOUR

T1 - Monitoring the reaction of the body state to antibiotic treatment against helicobacter pylori via infrared spectroscopy: A case study

AU - Maiti, Kiran Sankar

AU - Apolonski, Alexander

PY - 2021/6/1

Y1 - 2021/6/1

N2 - The current understanding of deviations of human microbiota caused by antibiotic treatment is poor. In an attempt to improve it, a proof-of-principle spectroscopic study of the breath of one volunteer affected by a course of antibiotics for Helicobacter pylori eradication was performed. Fourier transform spectroscopy enabled searching for the absorption spectral structures sensitive to the treatment in the entire mid-infrared region. Two spectral ranges were found where the corresponding structures strongly correlated with the beginning and end of the treatment. The structures were identified as methyl ester of butyric acid and ethyl ester of pyruvic acid. Both acids generated by bacteria in the gut are involved in fundamental processes of human metabolism. Being confirmed by other studies, measurement of the methyl butyrate deviation could be a promising way for monitoring acute gastritis and anti-Helicobacter pylori antibiotic treatment.

AB - The current understanding of deviations of human microbiota caused by antibiotic treatment is poor. In an attempt to improve it, a proof-of-principle spectroscopic study of the breath of one volunteer affected by a course of antibiotics for Helicobacter pylori eradication was performed. Fourier transform spectroscopy enabled searching for the absorption spectral structures sensitive to the treatment in the entire mid-infrared region. Two spectral ranges were found where the corresponding structures strongly correlated with the beginning and end of the treatment. The structures were identified as methyl ester of butyric acid and ethyl ester of pyruvic acid. Both acids generated by bacteria in the gut are involved in fundamental processes of human metabolism. Being confirmed by other studies, measurement of the methyl butyrate deviation could be a promising way for monitoring acute gastritis and anti-Helicobacter pylori antibiotic treatment.

KW - Acute gastritis

KW - Alpha-keto acid

KW - Antibiotic treatment

KW - Breath

KW - Helicobacter pylori

KW - Metabolites

KW - Mid-infrared spectroscopy

KW - Short-chain fatty acid

KW - Treatment dynamics: microbiota

KW - Volatile organic compound

KW - Helicobacter Infections/drug therapy

KW - Anti-Bacterial Agents/chemistry

KW - Humans

KW - Middle Aged

KW - Spectrophotometry, Infrared/methods

KW - Male

KW - Gastritis/drug therapy

KW - Helicobacter pylori/drug effects

KW - Gastrointestinal Microbiome/drug effects

KW - Butyric Acid/chemistry

KW - Pyruvic Acid/chemistry

KW - Esters/chemistry

UR - http://www.scopus.com/inward/record.url?scp=85108193131&partnerID=8YFLogxK

U2 - 10.3390/molecules26113474

DO - 10.3390/molecules26113474

M3 - Article

C2 - 34200454

AN - SCOPUS:85108193131

VL - 26

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 11

M1 - 3474

ER -

ID: 34032702