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Molecular determinants possibly involved in the adaptation of pandemic A(H1N1)09 influenza virus to a new host. / Prokopyeva, Elena; Romanovskaya, Alesia; Sharshov, Kirill et al.

In: Future Virology, Vol. 12, No. 9, 09.2017, p. 491-498.

Research output: Contribution to journal › Article › peer-review

Harvard

Prokopyeva, E, Romanovskaya, A, Sharshov, K, Sobolev, I, Alekseev, A, Durymanov, A & Shestopalov, A 2017, 'Molecular determinants possibly involved in the adaptation of pandemic A(H1N1)09 influenza virus to a new host', Future Virology, vol. 12, no. 9, pp. 491-498. https://doi.org/10.2217/fvl-2017-0026

APA

Prokopyeva, E., Romanovskaya, A., Sharshov, K., Sobolev, I., Alekseev, A., Durymanov, A., & Shestopalov, A. (2017). Molecular determinants possibly involved in the adaptation of pandemic A(H1N1)09 influenza virus to a new host. Future Virology, 12(9), 491-498. https://doi.org/10.2217/fvl-2017-0026

Vancouver

Prokopyeva E, Romanovskaya A, Sharshov K, Sobolev I, Alekseev A, Durymanov A et al. Molecular determinants possibly involved in the adaptation of pandemic A(H1N1)09 influenza virus to a new host. Future Virology. 2017 Sept;12(9):491-498. doi: 10.2217/fvl-2017-0026

Author

Prokopyeva, Elena ; Romanovskaya, Alesia ; Sharshov, Kirill et al. / Molecular determinants possibly involved in the adaptation of pandemic A(H1N1)09 influenza virus to a new host. In: Future Virology. 2017 ; Vol. 12, No. 9. pp. 491-498.

BibTeX

@article{8443cf1ae5014854ba2a1b6c719bd7e9,
title = "Molecular determinants possibly involved in the adaptation of pandemic A(H1N1)09 influenza virus to a new host",
abstract = "Aim: To determine the molecular basis of A(H1N1)pdm09 virus adaptation to a new host. Methods: The pandemic virus A/Russia/01/2009 was adapted to mice by serial lung-to-lung passages. The growth properties, pathogenicity and genome sequences of the mouse-adapted virus were compared with those of the parental strain. Results: The A(H1N1)pdm09 virus caused mouse death after only six lung-to-lung passages. Mutations in the influenza virus antigen were found in the brain, liver, kidney and in intestine by immunohistochemistry. Conclusion: Our findings suggest that multiple mutations in the viral genome promote rapid adaptation of the A(H1N1)pdm09 virus and cause generalized infection in mice.",
keywords = "A(H1N1)pdm09 virus adaptation, HA, IHC mice model, NA, PA, PB1, PB2",
author = "Elena Prokopyeva and Alesia Romanovskaya and Kirill Sharshov and Ivan Sobolev and Alexander Alekseev and Alexander Durymanov and Alexander Shestopalov",
note = "Publisher Copyright: {\textcopyright} 2017 Future Medicine Ltd.",
year = "2017",
month = sep,
doi = "10.2217/fvl-2017-0026",
language = "English",
volume = "12",
pages = "491--498",
journal = "Future Virology",
issn = "1746-0794",
publisher = "Future Medicine Ltd.",
number = "9",

}

RIS

TY - JOUR

T1 - Molecular determinants possibly involved in the adaptation of pandemic A(H1N1)09 influenza virus to a new host

AU - Prokopyeva, Elena

AU - Romanovskaya, Alesia

AU - Sharshov, Kirill

AU - Sobolev, Ivan

AU - Alekseev, Alexander

AU - Durymanov, Alexander

AU - Shestopalov, Alexander

N1 - Publisher Copyright: © 2017 Future Medicine Ltd.

PY - 2017/9

Y1 - 2017/9

N2 - Aim: To determine the molecular basis of A(H1N1)pdm09 virus adaptation to a new host. Methods: The pandemic virus A/Russia/01/2009 was adapted to mice by serial lung-to-lung passages. The growth properties, pathogenicity and genome sequences of the mouse-adapted virus were compared with those of the parental strain. Results: The A(H1N1)pdm09 virus caused mouse death after only six lung-to-lung passages. Mutations in the influenza virus antigen were found in the brain, liver, kidney and in intestine by immunohistochemistry. Conclusion: Our findings suggest that multiple mutations in the viral genome promote rapid adaptation of the A(H1N1)pdm09 virus and cause generalized infection in mice.

AB - Aim: To determine the molecular basis of A(H1N1)pdm09 virus adaptation to a new host. Methods: The pandemic virus A/Russia/01/2009 was adapted to mice by serial lung-to-lung passages. The growth properties, pathogenicity and genome sequences of the mouse-adapted virus were compared with those of the parental strain. Results: The A(H1N1)pdm09 virus caused mouse death after only six lung-to-lung passages. Mutations in the influenza virus antigen were found in the brain, liver, kidney and in intestine by immunohistochemistry. Conclusion: Our findings suggest that multiple mutations in the viral genome promote rapid adaptation of the A(H1N1)pdm09 virus and cause generalized infection in mice.

KW - A(H1N1)pdm09 virus adaptation

KW - HA

KW - IHC mice model

KW - NA

KW - PA

KW - PB1

KW - PB2

UR - http://www.scopus.com/inward/record.url?scp=85053255822&partnerID=8YFLogxK

U2 - 10.2217/fvl-2017-0026

DO - 10.2217/fvl-2017-0026

M3 - Article

AN - SCOPUS:85053255822

VL - 12

SP - 491

EP - 498

JO - Future Virology

JF - Future Virology

SN - 1746-0794

IS - 9

ER -

ID: 16567907