Modeling of the hemodynamics of vascular prostheses "Kemangiprotez" in Silico. / Klyshnikov, K. U.; Ovcharenko, E. A.; Borisov, V. G. et al.
In: Mathematical Biology and Bioinformatics, Vol. 12, No. 2, 2017, p. 559-569.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Modeling of the hemodynamics of vascular prostheses "Kemangiprotez" in Silico
AU - Klyshnikov, K. U.
AU - Ovcharenko, E. A.
AU - Borisov, V. G.
AU - Sizova, I. N.
AU - Burkov, N. N.
AU - Batranin, A. V.
AU - Kudryavtseva, Yu A.
AU - Zaharov, Yu N.
AU - Shokin, Yu I.
PY - 2017
Y1 - 2017
N2 - The paper describes aspects of the application of numerical simulation of fluid flows in clinical medicine with interventions on the human vascular system. The modeling method used in the study is verified using the data of the doppler sonography of the patient underwent vascular replacement. It was shown that the deviation between the numerical experiment and the clinical data - pressure curves at the inlet and outlet of the studied vessel, is 20%. The obtained quantitative characteristics of the flow: peak systolic velocity, final diastolic velocity, minimum diastolic velocity, resistivity index, pulsatility index, systole/diastole index are comparable between verification and experimental data. Thus, for the proximal site of the clinical vessel the corresponding indices were 96.5 cm/s; 4.5 cm/s; 36.2 cm/s; 1.05; 11.5; 21.3. For simulation, 107.9 cm/s; 4.44 cm/s; 43.9 cm/s; 1.05; 12.0; 24.3. In addition, the work describes the application of tested method in two clinical vascular prostheses "KemAngioprotez" for the assessment of zones of increased shear stress and, thus, the risk of thrombus formation. It is shown that the distribution of critical zones corresponds to zones of anastomosis between prosthesis segments, which may be a potential location for optimization of the device.
AB - The paper describes aspects of the application of numerical simulation of fluid flows in clinical medicine with interventions on the human vascular system. The modeling method used in the study is verified using the data of the doppler sonography of the patient underwent vascular replacement. It was shown that the deviation between the numerical experiment and the clinical data - pressure curves at the inlet and outlet of the studied vessel, is 20%. The obtained quantitative characteristics of the flow: peak systolic velocity, final diastolic velocity, minimum diastolic velocity, resistivity index, pulsatility index, systole/diastole index are comparable between verification and experimental data. Thus, for the proximal site of the clinical vessel the corresponding indices were 96.5 cm/s; 4.5 cm/s; 36.2 cm/s; 1.05; 11.5; 21.3. For simulation, 107.9 cm/s; 4.44 cm/s; 43.9 cm/s; 1.05; 12.0; 24.3. In addition, the work describes the application of tested method in two clinical vascular prostheses "KemAngioprotez" for the assessment of zones of increased shear stress and, thus, the risk of thrombus formation. It is shown that the distribution of critical zones corresponds to zones of anastomosis between prosthesis segments, which may be a potential location for optimization of the device.
KW - Computer modeling
KW - Doppler sonography
KW - Hydrodynamics
KW - Prosthesis
UR - http://www.scopus.com/inward/record.url?scp=85046542549&partnerID=8YFLogxK
U2 - 10.17537/2017.12.559
DO - 10.17537/2017.12.559
M3 - Article
AN - SCOPUS:85046542549
VL - 12
SP - 559
EP - 569
JO - Mathematical Biology and Bioinformatics
JF - Mathematical Biology and Bioinformatics
SN - 1994-6538
IS - 2
ER -
ID: 25314550