Research output: Contribution to journal › Article › peer-review
Modeling depression in zebrafish. / Galstyan, David S.; Kolesnikova, Tatyana O.; Kositsyn, Yurii M. et al.
In: Reviews on Clinical Pharmacology and Drug Therapy, Vol. 20, No. 2, 2022, p. 149-156.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Modeling depression in zebrafish
AU - Galstyan, David S.
AU - Kolesnikova, Tatyana O.
AU - Kositsyn, Yurii M.
AU - Zabegalov, Konstantin N.
AU - Gubaidullina, Mariya A.
AU - Maslov, Gleb O.
AU - Demin, Konstantin A.
AU - Khatsko, Sergey L.
AU - Kalueff, Allan V.
N1 - Публикация для корректировки.
PY - 2022
Y1 - 2022
N2 - Depression is a widespread, severely debilitating mental disorder characterized by low mood, anhedonia, fatigue, decreased attention, suicidality and psychomotor retardation, accompanied by neuroendocrine and molecular disorders. Zebrafish have neuroendocrine and neurotransmitter systems similar to humans, as well as high genetic homology, and are rapidly becoming popular model organisms for modeling depressive-like conditions. Here, we discuss modern behavioral, pharmacological and genetic models of depression in zebrafish, their methodological applications and translational implications.
AB - Depression is a widespread, severely debilitating mental disorder characterized by low mood, anhedonia, fatigue, decreased attention, suicidality and psychomotor retardation, accompanied by neuroendocrine and molecular disorders. Zebrafish have neuroendocrine and neurotransmitter systems similar to humans, as well as high genetic homology, and are rapidly becoming popular model organisms for modeling depressive-like conditions. Here, we discuss modern behavioral, pharmacological and genetic models of depression in zebrafish, their methodological applications and translational implications.
KW - chronic stress
KW - depression
KW - despair
KW - reserpine
KW - zebrafish
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85166761063&origin=inward&txGid=3770532788ca2421fff8ba85bc934f20
UR - https://www.mendeley.com/catalogue/58b42a26-fee3-3ef1-90dc-e50142b5db29/
U2 - 10.17816/RCF202149-156
DO - 10.17816/RCF202149-156
M3 - Article
VL - 20
SP - 149
EP - 156
JO - Reviews on Clinical Pharmacology and Drug Therapy
JF - Reviews on Clinical Pharmacology and Drug Therapy
SN - 2542-1875
IS - 2
ER -
ID: 55721703