Mixed-ligand copper(II) complexes with tetrazole derivatives and 2,2′-bipyridine, 1,10-phenanthroline

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Mixed-ligand copper(II) complexes with tetrazole derivatives and 2,2′-bipyridine, 1,10-phenanthroline : Synthesis, structure and cytotoxic activity. / Eremina, Julia A.; Lider, Elizaveta V.; Samsonenko, Denis G. et al.

In: Inorganica Chimica Acta, Vol. 487, 01.03.2019, p. 138-144.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{9ca6ee771b7f43ba8115c5aa45b6af45,

title = "Mixed-ligand copper(II) complexes with tetrazole derivatives and 2,2′-bipyridine, 1,10-phenanthroline: Synthesis, structure and cytotoxic activity",

abstract = "The [Cu2(2,2′-bipy)2(L1)4] (1), [Cu2(1,10-phen)2(L1)4] (2), [Cu(2,2′-bipy)(L2)2]n (3) and [Cu2(1,10-phen)2(L2)4] (4) complexes, where HL1 – 5-phenyltetrazole, and HL2 – 1H-tetrazole, have been synthesized. All complexes have been characterized by elemental analysis, IR, EPR spectroscopy and X-ray diffraction. The complexes possess distorted tetragonal-pyramidal coordination geometry. Compounds 1, 2, 4 show μ-5-phenyl-tetrazole/tetrazole bridged dinuclear structures, while compound 3 reveals polymeric structure. The effect of compounds on viability of the MCF-7 and Hep-2 cell lines was investigated in vitro. The study showed that tetrazole ligands HL1 and HL2 are non-toxic at tested concentrations (1–50 μM), while 1,10-phen and 2,2′-bipy posses cytotoxicity. All of the complexes exhibit significant dose-dependent cytotoxic effect and have the potential to act as efficient cytotoxic drugs. The complexes [Cu(1,10-phen)Cl2] (5) and [Cu(2,2′-bipy)Cl2] (6) have also been obtained to establish the influence of insertion of tetrazole ligands in compounds on their cytotoxic properties.",

keywords = "1,10-Phenanthroline, Cytotoxicity, Hep-2, MCF-7, Mixed ligand Cu(II) complexes, Tetrazole, OXIDATION, DNA CLEAVAGE, INTERCALATION, IN-VITRO, CHEMISTRY, INHIBITOR, BOND",

author = "Eremina, {Julia A.} and Lider, {Elizaveta V.} and Samsonenko, {Denis G.} and Sheludyakova, {Liliya A.} and Berezin, {Alexey S.} and Klyushova, {Lyubov S.} and Ostrovskii, {Vladimir A.} and Trifonov, {Rostislav E.}",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2019",

month = mar,

day = "1",

doi = "10.1016/j.ica.2018.12.011",

language = "English",

volume = "487",

pages = "138--144",

journal = "Inorganica Chimica Acta",

issn = "0020-1693",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Mixed-ligand copper(II) complexes with tetrazole derivatives and 2,2′-bipyridine, 1,10-phenanthroline

T2 - Synthesis, structure and cytotoxic activity

AU - Eremina, Julia A.

AU - Lider, Elizaveta V.

AU - Samsonenko, Denis G.

AU - Sheludyakova, Liliya A.

AU - Berezin, Alexey S.

AU - Klyushova, Lyubov S.

AU - Ostrovskii, Vladimir A.

AU - Trifonov, Rostislav E.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - The [Cu2(2,2′-bipy)2(L1)4] (1), [Cu2(1,10-phen)2(L1)4] (2), [Cu(2,2′-bipy)(L2)2]n (3) and [Cu2(1,10-phen)2(L2)4] (4) complexes, where HL1 – 5-phenyltetrazole, and HL2 – 1H-tetrazole, have been synthesized. All complexes have been characterized by elemental analysis, IR, EPR spectroscopy and X-ray diffraction. The complexes possess distorted tetragonal-pyramidal coordination geometry. Compounds 1, 2, 4 show μ-5-phenyl-tetrazole/tetrazole bridged dinuclear structures, while compound 3 reveals polymeric structure. The effect of compounds on viability of the MCF-7 and Hep-2 cell lines was investigated in vitro. The study showed that tetrazole ligands HL1 and HL2 are non-toxic at tested concentrations (1–50 μM), while 1,10-phen and 2,2′-bipy posses cytotoxicity. All of the complexes exhibit significant dose-dependent cytotoxic effect and have the potential to act as efficient cytotoxic drugs. The complexes [Cu(1,10-phen)Cl2] (5) and [Cu(2,2′-bipy)Cl2] (6) have also been obtained to establish the influence of insertion of tetrazole ligands in compounds on their cytotoxic properties.

AB - The [Cu2(2,2′-bipy)2(L1)4] (1), [Cu2(1,10-phen)2(L1)4] (2), [Cu(2,2′-bipy)(L2)2]n (3) and [Cu2(1,10-phen)2(L2)4] (4) complexes, where HL1 – 5-phenyltetrazole, and HL2 – 1H-tetrazole, have been synthesized. All complexes have been characterized by elemental analysis, IR, EPR spectroscopy and X-ray diffraction. The complexes possess distorted tetragonal-pyramidal coordination geometry. Compounds 1, 2, 4 show μ-5-phenyl-tetrazole/tetrazole bridged dinuclear structures, while compound 3 reveals polymeric structure. The effect of compounds on viability of the MCF-7 and Hep-2 cell lines was investigated in vitro. The study showed that tetrazole ligands HL1 and HL2 are non-toxic at tested concentrations (1–50 μM), while 1,10-phen and 2,2′-bipy posses cytotoxicity. All of the complexes exhibit significant dose-dependent cytotoxic effect and have the potential to act as efficient cytotoxic drugs. The complexes [Cu(1,10-phen)Cl2] (5) and [Cu(2,2′-bipy)Cl2] (6) have also been obtained to establish the influence of insertion of tetrazole ligands in compounds on their cytotoxic properties.

KW - 1,10-Phenanthroline

KW - Cytotoxicity

KW - Hep-2

KW - MCF-7

KW - Mixed ligand Cu(II) complexes

KW - Tetrazole

KW - OXIDATION

KW - DNA CLEAVAGE

KW - INTERCALATION

KW - IN-VITRO

KW - CHEMISTRY

KW - INHIBITOR

KW - BOND

UR - http://www.scopus.com/inward/record.url?scp=85058157945&partnerID=8YFLogxK

U2 - 10.1016/j.ica.2018.12.011

DO - 10.1016/j.ica.2018.12.011

M3 - Article

AN - SCOPUS:85058157945

VL - 487

SP - 138

EP - 144

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

SN - 0020-1693

ER -

ID: 17828613

Mixed-ligand copper(II) complexes with tetrazole derivatives and 2,2′-bipyridine, 1,10-phenanthroline: Synthesis, structure and cytotoxic activity

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