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Mitochondrial dysfunction and potential anticancer therapy. / Lleonart, Matilde E.; Grodzicki, Robert; Graifer, Dmitri M. et al.

In: Medicinal Research Reviews, Vol. 37, No. 6, 01.11.2017, p. 1275-1298.

Research output: Contribution to journal › Review article › peer-review

Harvard

Lleonart, ME, Grodzicki, R, Graifer, DM & Lyakhovich, A 2017, 'Mitochondrial dysfunction and potential anticancer therapy', Medicinal Research Reviews, vol. 37, no. 6, pp. 1275-1298. https://doi.org/10.1002/med.21459

APA

Lleonart, M. E., Grodzicki, R., Graifer, D. M., & Lyakhovich, A. (2017). Mitochondrial dysfunction and potential anticancer therapy. Medicinal Research Reviews, 37(6), 1275-1298. https://doi.org/10.1002/med.21459

Vancouver

Lleonart ME, Grodzicki R, Graifer DM, Lyakhovich A. Mitochondrial dysfunction and potential anticancer therapy. Medicinal Research Reviews. 2017 Nov 1;37(6):1275-1298. doi: 10.1002/med.21459

Author

Lleonart, Matilde E. ; Grodzicki, Robert ; Graifer, Dmitri M. et al. / Mitochondrial dysfunction and potential anticancer therapy. In: Medicinal Research Reviews. 2017 ; Vol. 37, No. 6. pp. 1275-1298.

BibTeX

@article{9f7c4d4e12c64e76ab77619e10a4f043,
title = "Mitochondrial dysfunction and potential anticancer therapy",
abstract = "Mitochondrial dysfunction (MDF) has been identified as an important factor in various diseases ranging from neurological disorders, to diseases of the cardiovascular system and metabolic syndromes. MDF was also found in cancer as well as in cancer predisposition syndromes with defective DNA damage response (DDR) machinery. Moreover, a recent highlight arises from the detection of MDF in eukaryotic cells upon treatment with antibiotics. In this review, we focus on recent studies of MDF in pathological conditions with a particular emphasis on the effects of various classes of antibiotics on mitochondria. Special attention is given to the role of autophagy/mitophagy in MDF and repurposing antibiotics as anticancer drugs.",
keywords = "antibiotics, autophagy, cancer, cancer stem cells, mitochondria, mitochondrial dysfunction, mitophagy, Animals, Neoplasms/metabolism, Mitochondria/metabolism, Humans",
author = "Lleonart, {Matilde E.} and Robert Grodzicki and Graifer, {Dmitri M.} and Alex Lyakhovich",
note = "{\textcopyright} 2017 Wiley Periodicals, Inc.",
year = "2017",
month = nov,
day = "1",
doi = "10.1002/med.21459",
language = "English",
volume = "37",
pages = "1275--1298",
journal = "Medicinal Research Reviews",
issn = "0198-6325",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Mitochondrial dysfunction and potential anticancer therapy

AU - Lleonart, Matilde E.

AU - Grodzicki, Robert

AU - Graifer, Dmitri M.

AU - Lyakhovich, Alex

N1 - © 2017 Wiley Periodicals, Inc.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Mitochondrial dysfunction (MDF) has been identified as an important factor in various diseases ranging from neurological disorders, to diseases of the cardiovascular system and metabolic syndromes. MDF was also found in cancer as well as in cancer predisposition syndromes with defective DNA damage response (DDR) machinery. Moreover, a recent highlight arises from the detection of MDF in eukaryotic cells upon treatment with antibiotics. In this review, we focus on recent studies of MDF in pathological conditions with a particular emphasis on the effects of various classes of antibiotics on mitochondria. Special attention is given to the role of autophagy/mitophagy in MDF and repurposing antibiotics as anticancer drugs.

AB - Mitochondrial dysfunction (MDF) has been identified as an important factor in various diseases ranging from neurological disorders, to diseases of the cardiovascular system and metabolic syndromes. MDF was also found in cancer as well as in cancer predisposition syndromes with defective DNA damage response (DDR) machinery. Moreover, a recent highlight arises from the detection of MDF in eukaryotic cells upon treatment with antibiotics. In this review, we focus on recent studies of MDF in pathological conditions with a particular emphasis on the effects of various classes of antibiotics on mitochondria. Special attention is given to the role of autophagy/mitophagy in MDF and repurposing antibiotics as anticancer drugs.

KW - antibiotics

KW - autophagy

KW - cancer

KW - cancer stem cells

KW - mitochondria

KW - mitochondrial dysfunction

KW - mitophagy

KW - Animals

KW - Neoplasms/metabolism

KW - Mitochondria/metabolism

KW - Humans

UR - http://www.scopus.com/inward/record.url?scp=85021812495&partnerID=8YFLogxK

U2 - 10.1002/med.21459

DO - 10.1002/med.21459

M3 - Review article

C2 - 28682452

AN - SCOPUS:85021812495

VL - 37

SP - 1275

EP - 1298

JO - Medicinal Research Reviews

JF - Medicinal Research Reviews

SN - 0198-6325

IS - 6

ER -

ID: 9068767