Standard

Mitochondria with Morphology Characteristic for Alzheimer’s Disease Patients Are Found in the Brain of OXYS Rats. / Tyumentsev, M. A.; Stefanova, N. A.; Kiseleva, E. V. et al.

In: Biochemistry (Moscow), Vol. 83, No. 9, 01.09.2018, p. 1083-1088.

Research output: Contribution to journalArticlepeer-review

Harvard

Tyumentsev, MA, Stefanova, NA, Kiseleva, EV & Kolosova, NG 2018, 'Mitochondria with Morphology Characteristic for Alzheimer’s Disease Patients Are Found in the Brain of OXYS Rats', Biochemistry (Moscow), vol. 83, no. 9, pp. 1083-1088. https://doi.org/10.1134/S0006297918090109

APA

Tyumentsev, M. A., Stefanova, N. A., Kiseleva, E. V., & Kolosova, N. G. (2018). Mitochondria with Morphology Characteristic for Alzheimer’s Disease Patients Are Found in the Brain of OXYS Rats. Biochemistry (Moscow), 83(9), 1083-1088. https://doi.org/10.1134/S0006297918090109

Vancouver

Tyumentsev MA, Stefanova NA, Kiseleva EV, Kolosova NG. Mitochondria with Morphology Characteristic for Alzheimer’s Disease Patients Are Found in the Brain of OXYS Rats. Biochemistry (Moscow). 2018 Sept 1;83(9):1083-1088. doi: 10.1134/S0006297918090109

Author

Tyumentsev, M. A. ; Stefanova, N. A. ; Kiseleva, E. V. et al. / Mitochondria with Morphology Characteristic for Alzheimer’s Disease Patients Are Found in the Brain of OXYS Rats. In: Biochemistry (Moscow). 2018 ; Vol. 83, No. 9. pp. 1083-1088.

BibTeX

@article{8cca3cf126b249f48405f57d237ddc43,
title = "Mitochondria with Morphology Characteristic for Alzheimer{\textquoteright}s Disease Patients Are Found in the Brain of OXYS Rats",
abstract = "Growing evidence suggests that mitochondrial dysfunction is closely linked to the pathogenesis of sporadic Alzheimer{\textquoteright}s disease (AD). One of the key contributors to various aspects of AD pathogenesis, along with metabolic dysfunction, is mitochondrial dynamics, involving balance between fusion and fission, which regulates mitochondrial number and morphology in response to changes in cellular energy demand. Recently, Zhang et al. ((2016) Sci. Rep., 6, 18725) described a previously unknown mitochondrial phenotype manifesting as elongated chain-linked mitochondria termed “mitochondria-on-a-string” (MOAS) in brain tissue from AD patients and mouse models of AD. The authors associated this phenotype with fission arrest, but implications of MOAS formation in AD pathogenesis remain to be understood. Here we analyze the presence and number of MOAS in the brain of OXYS rats simulating key signs of sporadic AD. Using electron microscopy, we found MOAS in OXYS prefrontal cortex neuropil in all stages of AD-like pathology, including mani-festation (5-month-old rats) and progression (12–18-month-old rats). The most pronounced elevation of MOAS content (8–fold) in OXYS rats compared to Wistar controls was found at the preclinical stage (20 days) on the background of decreased numbers of non-MOAS elongated mitochondria. From the age of 20 days through 18 months, the percentage of MOAS-containing neuronal processes increased from 1.7 to 8.3% in Wistar and from 13.9 to 16% in OXYS rats. Our results support the importance of the disruption of mitochondrial dynamics in AD pathogenesis and corroborate the existence of a causal link between impaired mitochondrial dynamics and formation of the distinctive phenotype of “mitochondria-on-a-sting”.",
keywords = "Alzheimer{\textquoteright}s disease, electron microscopy, mitochondrial dynamics, OXYS rats",
author = "Tyumentsev, {M. A.} and Stefanova, {N. A.} and Kiseleva, {E. V.} and Kolosova, {N. G.}",
year = "2018",
month = sep,
day = "1",
doi = "10.1134/S0006297918090109",
language = "English",
volume = "83",
pages = "1083--1088",
journal = "Biochemistry (Moscow)",
issn = "0006-2979",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "9",

}

RIS

TY - JOUR

T1 - Mitochondria with Morphology Characteristic for Alzheimer’s Disease Patients Are Found in the Brain of OXYS Rats

AU - Tyumentsev, M. A.

AU - Stefanova, N. A.

AU - Kiseleva, E. V.

AU - Kolosova, N. G.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Growing evidence suggests that mitochondrial dysfunction is closely linked to the pathogenesis of sporadic Alzheimer’s disease (AD). One of the key contributors to various aspects of AD pathogenesis, along with metabolic dysfunction, is mitochondrial dynamics, involving balance between fusion and fission, which regulates mitochondrial number and morphology in response to changes in cellular energy demand. Recently, Zhang et al. ((2016) Sci. Rep., 6, 18725) described a previously unknown mitochondrial phenotype manifesting as elongated chain-linked mitochondria termed “mitochondria-on-a-string” (MOAS) in brain tissue from AD patients and mouse models of AD. The authors associated this phenotype with fission arrest, but implications of MOAS formation in AD pathogenesis remain to be understood. Here we analyze the presence and number of MOAS in the brain of OXYS rats simulating key signs of sporadic AD. Using electron microscopy, we found MOAS in OXYS prefrontal cortex neuropil in all stages of AD-like pathology, including mani-festation (5-month-old rats) and progression (12–18-month-old rats). The most pronounced elevation of MOAS content (8–fold) in OXYS rats compared to Wistar controls was found at the preclinical stage (20 days) on the background of decreased numbers of non-MOAS elongated mitochondria. From the age of 20 days through 18 months, the percentage of MOAS-containing neuronal processes increased from 1.7 to 8.3% in Wistar and from 13.9 to 16% in OXYS rats. Our results support the importance of the disruption of mitochondrial dynamics in AD pathogenesis and corroborate the existence of a causal link between impaired mitochondrial dynamics and formation of the distinctive phenotype of “mitochondria-on-a-sting”.

AB - Growing evidence suggests that mitochondrial dysfunction is closely linked to the pathogenesis of sporadic Alzheimer’s disease (AD). One of the key contributors to various aspects of AD pathogenesis, along with metabolic dysfunction, is mitochondrial dynamics, involving balance between fusion and fission, which regulates mitochondrial number and morphology in response to changes in cellular energy demand. Recently, Zhang et al. ((2016) Sci. Rep., 6, 18725) described a previously unknown mitochondrial phenotype manifesting as elongated chain-linked mitochondria termed “mitochondria-on-a-string” (MOAS) in brain tissue from AD patients and mouse models of AD. The authors associated this phenotype with fission arrest, but implications of MOAS formation in AD pathogenesis remain to be understood. Here we analyze the presence and number of MOAS in the brain of OXYS rats simulating key signs of sporadic AD. Using electron microscopy, we found MOAS in OXYS prefrontal cortex neuropil in all stages of AD-like pathology, including mani-festation (5-month-old rats) and progression (12–18-month-old rats). The most pronounced elevation of MOAS content (8–fold) in OXYS rats compared to Wistar controls was found at the preclinical stage (20 days) on the background of decreased numbers of non-MOAS elongated mitochondria. From the age of 20 days through 18 months, the percentage of MOAS-containing neuronal processes increased from 1.7 to 8.3% in Wistar and from 13.9 to 16% in OXYS rats. Our results support the importance of the disruption of mitochondrial dynamics in AD pathogenesis and corroborate the existence of a causal link between impaired mitochondrial dynamics and formation of the distinctive phenotype of “mitochondria-on-a-sting”.

KW - Alzheimer’s disease

KW - electron microscopy

KW - mitochondrial dynamics

KW - OXYS rats

UR - http://www.scopus.com/inward/record.url?scp=85053429156&partnerID=8YFLogxK

U2 - 10.1134/S0006297918090109

DO - 10.1134/S0006297918090109

M3 - Article

C2 - 30472947

AN - SCOPUS:85053429156

VL - 83

SP - 1083

EP - 1088

JO - Biochemistry (Moscow)

JF - Biochemistry (Moscow)

SN - 0006-2979

IS - 9

ER -

ID: 16600589