Humans, DNA-Directed DNA Polymerase/metabolism, DNA Methylation, Cytosine/metabolism, 5-Methylcytosine/metabolism, DNA Repair, DNA Damage, Nucleotidyltransferases/metabolism, DNA Polymerase iota, DNA/metabolism, Multifunctional Enzymes/metabolism, DNA Replication, 8-Hydroxy-2'-Deoxyguanosine/metabolism