Research output: Contribution to journal › Article › peer-review
Mechanisms of Neuronal Death in the Cerebral Cortex during Aging and Development of Alzheimer's Disease-Like Pathology in Rats. / Telegina, Darya V.; Suvorov, Gleb K.; Kozhevnikova, Oyuna S. et al.
In: International Journal of Molecular Sciences, Vol. 20, No. 22, 5632, 11.11.2019.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Mechanisms of Neuronal Death in the Cerebral Cortex during Aging and Development of Alzheimer's Disease-Like Pathology in Rats
AU - Telegina, Darya V.
AU - Suvorov, Gleb K.
AU - Kozhevnikova, Oyuna S.
AU - Kolosova, Nataliya G.
N1 - Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019/11/11
Y1 - 2019/11/11
N2 - Alzheimer's disease (AD) is the commonest type of late-life dementia and damages the cerebral cortex, a vulnerable brain region implicated in memory, emotion, cognition, and decision-making behavior. AD is characterized by progressive neuronal loss, but the mechanisms of cell death at different stages of the disease remain unknown. Here, by means of OXYS rats as an appropriate model of the most common (sporadic) AD form, we studied the main pathways of cell death during development of AD-like pathology, including the preclinical stage. We found that apoptosis is activated at the pre-symptomatic stage (age 20 days) correlating with the retardation of brain development in the OXYS strain early in life. Progression of the AD-like pathology was accompanied by activation of apoptosis and necroptosis resulting from a decline of autophagy-mediated proteostasis. Our results are consistent with the idea that the nature of changes in the pathways of apoptosis, autophagy, and necrosis depends on the stage of AD.
AB - Alzheimer's disease (AD) is the commonest type of late-life dementia and damages the cerebral cortex, a vulnerable brain region implicated in memory, emotion, cognition, and decision-making behavior. AD is characterized by progressive neuronal loss, but the mechanisms of cell death at different stages of the disease remain unknown. Here, by means of OXYS rats as an appropriate model of the most common (sporadic) AD form, we studied the main pathways of cell death during development of AD-like pathology, including the preclinical stage. We found that apoptosis is activated at the pre-symptomatic stage (age 20 days) correlating with the retardation of brain development in the OXYS strain early in life. Progression of the AD-like pathology was accompanied by activation of apoptosis and necroptosis resulting from a decline of autophagy-mediated proteostasis. Our results are consistent with the idea that the nature of changes in the pathways of apoptosis, autophagy, and necrosis depends on the stage of AD.
KW - Alzheimer’s disease
KW - apoptosis
KW - autophagy
KW - necroptosis
KW - neuronal cell death
KW - OXYS rats
KW - Necroptosis
KW - Neuronal cell death
KW - Autophagy
KW - Apoptosis
KW - NECROPTOSIS
KW - ISCHEMIC MODEL
KW - INVOLVEMENT
KW - MITOPHAGY
KW - AUTOPHAGY
KW - CELL-DEATH
KW - OXYS RATS
KW - Alzheimer's disease
KW - BRAIN
KW - AGE
UR - http://www.scopus.com/inward/record.url?scp=85074949663&partnerID=8YFLogxK
U2 - 10.3390/ijms20225632
DO - 10.3390/ijms20225632
M3 - Article
C2 - 31717998
AN - SCOPUS:85074949663
VL - 20
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 22
M1 - 5632
ER -
ID: 22364288