TY - JOUR

T1 - Mechanism of gas molecule transport through erythrocytes’ membranes by kinks-solitons

AU - Mokrushnikov, P. V.

AU - Rudyak, V. Ya

AU - Lezhnev, E. V.

N1 - Funding Information: This work was financially supported by the Russian Foundation for Basic Research (Grant No. 19-01-00399). Publisher Copyright: © 2021, ITMO University. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021

Y1 - 2021

N2 - A model of kinks appearance in the lipid bilayer membrane of erythrocytes, which are responsible for gas molecule transport, in particular, oxygen, is proposed. It was shown that the kinks arise due to the simultaneous action of transverse and tensile longitudinal mechanical stresses compressing the membrane. This model explains the membrane’s permeability sharp increase for gases during an erythrocyte passage through the microcapillary network with the compressive transverse mechanical stresses sharply increasing in its membrane. It was found that the equation of kinks motion has a soliton solution, so that a kink-soliton is formed in the bilayer of the erythrocyte membrane. The developed model is consistent with the previously experimentally established fact that the native erythrocyte membranes in the bloodstream undergo a structural transition, when small changes in blood pH, hormone concentration, and temperature dramatically change the conformation of the biomembranes and its functions by changing the mechanical stress field in the biomembrane.

AB - A model of kinks appearance in the lipid bilayer membrane of erythrocytes, which are responsible for gas molecule transport, in particular, oxygen, is proposed. It was shown that the kinks arise due to the simultaneous action of transverse and tensile longitudinal mechanical stresses compressing the membrane. This model explains the membrane’s permeability sharp increase for gases during an erythrocyte passage through the microcapillary network with the compressive transverse mechanical stresses sharply increasing in its membrane. It was found that the equation of kinks motion has a soliton solution, so that a kink-soliton is formed in the bilayer of the erythrocyte membrane. The developed model is consistent with the previously experimentally established fact that the native erythrocyte membranes in the bloodstream undergo a structural transition, when small changes in blood pH, hormone concentration, and temperature dramatically change the conformation of the biomembranes and its functions by changing the mechanical stress field in the biomembrane.

KW - Biomembrane

KW - Diffusion

KW - Erythrocyte

KW - Kinks

KW - Mechanical stress in biomembranes

KW - Microcapillary

KW - Nanosystem

UR - http://www.scopus.com/inward/record.url?scp=85102688773&partnerID=8YFLogxK

U2 - 10.17586/2220-8054-2021-12-1-22-31

DO - 10.17586/2220-8054-2021-12-1-22-31

M3 - Article

AN - SCOPUS:85102688773

VL - 12

SP - 22

EP - 31

JO - Nanosystems-Physics chemistry mathematics

JF - Nanosystems-Physics chemistry mathematics

SN - 2220-8054

IS - 1

ER -