Mathematical and Numerical Models of the Central Regulatory Circuit of the Morphogenesis System of Drosophila

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Mathematical and Numerical Models of the Central Regulatory Circuit of the Morphogenesis System of Drosophila. / Bukharina, T. A.; Akinshin, A. A.; Golubyatnikov, V. P. et al.

In: Journal of Applied and Industrial Mathematics, Vol. 14, No. 2, 01.05.2020, p. 249-255.

Research output: Contribution to journal › Article › peer-review

Author

Bukharina, T. A. ; Akinshin, A. A. ; Golubyatnikov, V. P. et al. / Mathematical and Numerical Models of the Central Regulatory Circuit of the Morphogenesis System of Drosophila. In: Journal of Applied and Industrial Mathematics. 2020 ; Vol. 14, No. 2. pp. 249-255.

BibTeX

@article{6105b1a2f96247cfb8302e85031f5e51,

title = "Mathematical and Numerical Models of the Central Regulatory Circuit of the Morphogenesis System of Drosophila",

abstract = "The results are presented of mathematical and computer simulation of the functioning ofthe central regulatory circuit (CRC) which is the system integrator of the gene networks ofmorphogenesis of Drosophila mechanoreceptors. The main element of the CRC is represented bythe complex of Achaete-Scute (AS-C) genes, the main genes of the mechanoreceptor morphogenesis.The content level of the proteins encoded by the AS-Cgenes is a determining factor for initiating the development of a mechanoreceptor. We carried outa comparative study of the CRC behavior under normal conditions and in the presence ofmutational changes in the Achaete-Scute complex. Theresults of simulation are in good accord with the available biological data.",

keywords = "Achaete-Scute complex, central regulatory circuit, Drosophila, gene network, mathematical model, mechanoreceptor, mutation, nonlinear dynamical system, numerical simulation",

author = "Bukharina, {T. A.} and Akinshin, {A. A.} and Golubyatnikov, {V. P.} and Furman, {D. P.}",

year = "2020",

month = may,

day = "1",

doi = "10.1134/S1990478920020040",

language = "English",

volume = "14",

pages = "249--255",

journal = "Journal of Applied and Industrial Mathematics",

issn = "1990-4789",

publisher = "Maik Nauka-Interperiodica Publishing",

number = "2",

}

RIS

TY - JOUR

T1 - Mathematical and Numerical Models of the Central Regulatory Circuit of the Morphogenesis System of Drosophila

AU - Bukharina, T. A.

AU - Akinshin, A. A.

AU - Golubyatnikov, V. P.

AU - Furman, D. P.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - The results are presented of mathematical and computer simulation of the functioning ofthe central regulatory circuit (CRC) which is the system integrator of the gene networks ofmorphogenesis of Drosophila mechanoreceptors. The main element of the CRC is represented bythe complex of Achaete-Scute (AS-C) genes, the main genes of the mechanoreceptor morphogenesis.The content level of the proteins encoded by the AS-Cgenes is a determining factor for initiating the development of a mechanoreceptor. We carried outa comparative study of the CRC behavior under normal conditions and in the presence ofmutational changes in the Achaete-Scute complex. Theresults of simulation are in good accord with the available biological data.

AB - The results are presented of mathematical and computer simulation of the functioning ofthe central regulatory circuit (CRC) which is the system integrator of the gene networks ofmorphogenesis of Drosophila mechanoreceptors. The main element of the CRC is represented bythe complex of Achaete-Scute (AS-C) genes, the main genes of the mechanoreceptor morphogenesis.The content level of the proteins encoded by the AS-Cgenes is a determining factor for initiating the development of a mechanoreceptor. We carried outa comparative study of the CRC behavior under normal conditions and in the presence ofmutational changes in the Achaete-Scute complex. Theresults of simulation are in good accord with the available biological data.

KW - Achaete-Scute complex

KW - central regulatory circuit

KW - Drosophila

KW - gene network

KW - mathematical model

KW - mechanoreceptor

KW - mutation

KW - nonlinear dynamical system

KW - numerical simulation

UR - http://www.scopus.com/inward/record.url?scp=85087767751&partnerID=8YFLogxK

U2 - 10.1134/S1990478920020040

DO - 10.1134/S1990478920020040

M3 - Article

AN - SCOPUS:85087767751

VL - 14

SP - 249

EP - 255

JO - Journal of Applied and Industrial Mathematics

JF - Journal of Applied and Industrial Mathematics

SN - 1990-4789

IS - 2

ER -

ID: 24737410