Lymph nodes morphology as predictor natural and premature aging. / Gorchakova, Olga; Горчаков, Владимир Николаевич; Demchenko, Georgy.
Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia). Novosibirsk: ICG SB RAS : Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, 2020. p. 642-643.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review
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TY - GEN
T1 - Lymph nodes morphology as predictor natural and premature aging
AU - Gorchakova, Olga
AU - Горчаков, Владимир Николаевич
AU - Demchenko, Georgy
N1 - Conference code: 12
PY - 2020/7
Y1 - 2020/7
N2 - The research purpose is to estimate the structural organization of lymph nodes of different localization at natural (physiological) and premature aging respectively at OXYS and Wistar rats. We used a morphological method of a research. The age-induced changes of lymphoid tissue of Wistar and OXYS rats differ with type of the immune response and morphological variant of lymph nodes structure. The immune response on humoral type is formed in mesenteric and inguinal lymph nodes, and the immune response on cellular type is formed in a tracheobronchial lymph node. We noted reduction of structures of cortical substance, especially lymphoid follicles and a paracortex, and expansion of medullary substance in a lymph node of OXYS rats. Lymph nodes are subject big morphological changes at rats of OXYS, than at old rats of Wistar. Observed changes of structure of lymph nodes of OXYS rats are a morphological equivalent of premature aging and confirms early decrease of a drainage and immune function of lymph nodes
AB - The research purpose is to estimate the structural organization of lymph nodes of different localization at natural (physiological) and premature aging respectively at OXYS and Wistar rats. We used a morphological method of a research. The age-induced changes of lymphoid tissue of Wistar and OXYS rats differ with type of the immune response and morphological variant of lymph nodes structure. The immune response on humoral type is formed in mesenteric and inguinal lymph nodes, and the immune response on cellular type is formed in a tracheobronchial lymph node. We noted reduction of structures of cortical substance, especially lymphoid follicles and a paracortex, and expansion of medullary substance in a lymph node of OXYS rats. Lymph nodes are subject big morphological changes at rats of OXYS, than at old rats of Wistar. Observed changes of structure of lymph nodes of OXYS rats are a morphological equivalent of premature aging and confirms early decrease of a drainage and immune function of lymph nodes
UR - https://www.elibrary.ru/item.asp?id=44042507
U2 - 10.18699/BGRS/SB-2020-392
DO - 10.18699/BGRS/SB-2020-392
M3 - Conference contribution
SN - 978-5-91291-051-7
SP - 642
EP - 643
BT - Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia)
PB - Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences
CY - Novosibirsk: ICG SB RAS
T2 - Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia)
Y2 - 6 July 2020 through 10 July 2020
ER -
ID: 25097819