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Low-Flammable Parahydrogen-Polarized MRI Contrast Agents. / Joalland, Baptiste; Ariyasingha, Nuwandi M.; Younes, Hassan R. et al.

In: Chemistry - A European Journal, Vol. 27, No. 8, 05.02.2021, p. 2774-2781.

Research output: Contribution to journal › Article › peer-review

Harvard

Joalland, B, Ariyasingha, NM, Younes, HR, Nantogma, S, Salnikov, OG, Chukanov, NV, Kovtunov, KV, Koptyug, IV, Gelovani, JG & Chekmenev, EY 2021, 'Low-Flammable Parahydrogen-Polarized MRI Contrast Agents', Chemistry - A European Journal, vol. 27, no. 8, pp. 2774-2781. https://doi.org/10.1002/chem.202004168

APA

Joalland, B., Ariyasingha, N. M., Younes, H. R., Nantogma, S., Salnikov, O. G., Chukanov, N. V., Kovtunov, K. V., Koptyug, I. V., Gelovani, J. G., & Chekmenev, E. Y. (2021). Low-Flammable Parahydrogen-Polarized MRI Contrast Agents. Chemistry - A European Journal, 27(8), 2774-2781. https://doi.org/10.1002/chem.202004168

Vancouver

Joalland B, Ariyasingha NM, Younes HR, Nantogma S, Salnikov OG, Chukanov NV et al. Low-Flammable Parahydrogen-Polarized MRI Contrast Agents. Chemistry - A European Journal. 2021 Feb 5;27(8):2774-2781. Epub 2020 Oct 28. doi: 10.1002/chem.202004168

Author

Joalland, Baptiste ; Ariyasingha, Nuwandi M. ; Younes, Hassan R. et al. / Low-Flammable Parahydrogen-Polarized MRI Contrast Agents. In: Chemistry - A European Journal. 2021 ; Vol. 27, No. 8. pp. 2774-2781.

BibTeX

@article{d14046eefd884adf91c3263a55d1c016,
title = "Low-Flammable Parahydrogen-Polarized MRI Contrast Agents",
abstract = "Many MRI contrast agents formed with the parahydrogen-induced polarization (PHIP) technique exhibit biocompatible profiles. In the context of respiratory imaging with inhalable molecular contrast agents, the development of nonflammable contrast agents would nonetheless be highly beneficial for the biomedical translation of this sensitive, high-throughput and affordable hyperpolarization technique. To this end, we assess the hydrogenation kinetics, the polarization levels and the lifetimes of PHIP hyperpolarized products (acids, ethers and esters) at various degrees of fluorine substitution. The results highlight important trends as a function of molecular structure that are instrumental for the design of new, safe contrast agents for in vivo imaging applications of the PHIP technique, with an emphasis on the highly volatile group of ethers used as inhalable anesthetics.",
keywords = "flammability, fluorine, hyperpolarization, inhalable anesthetics, parahydrogen",
author = "Baptiste Joalland and Ariyasingha, {Nuwandi M.} and Younes, {Hassan R.} and Shiraz Nantogma and Salnikov, {Oleg G.} and Chukanov, {Nikita V.} and Kovtunov, {Kirill V.} and Koptyug, {Igor V.} and Gelovani, {Juri G.} and Chekmenev, {Eduard Y.}",
note = "Funding Information: This work was supported by the National Science Foundation CHE‐1904780, NHLBI 1R21HL154032, and DOD CDMRP W81XWH‐15‐1‐0271 and W81XWH‐20‐1‐0576. The Russian team thanks the Russian Foundation for Basic Research (Grants 17‐54‐33037, 19‐53‐12013, 19‐29‐10003, 19‐33‐60045) and the Russian Ministry of Science and Higher Education (Grant AAAA‐A16‐116121510087‐5). Publisher Copyright: {\textcopyright} 2020 Wiley-VCH GmbH Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = feb,
day = "5",
doi = "10.1002/chem.202004168",
language = "English",
volume = "27",
pages = "2774--2781",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "8",

}

RIS

TY - JOUR

T1 - Low-Flammable Parahydrogen-Polarized MRI Contrast Agents

AU - Joalland, Baptiste

AU - Ariyasingha, Nuwandi M.

AU - Younes, Hassan R.

AU - Nantogma, Shiraz

AU - Salnikov, Oleg G.

AU - Chukanov, Nikita V.

AU - Kovtunov, Kirill V.

AU - Koptyug, Igor V.

AU - Gelovani, Juri G.

AU - Chekmenev, Eduard Y.

N1 - Funding Information: This work was supported by the National Science Foundation CHE‐1904780, NHLBI 1R21HL154032, and DOD CDMRP W81XWH‐15‐1‐0271 and W81XWH‐20‐1‐0576. The Russian team thanks the Russian Foundation for Basic Research (Grants 17‐54‐33037, 19‐53‐12013, 19‐29‐10003, 19‐33‐60045) and the Russian Ministry of Science and Higher Education (Grant AAAA‐A16‐116121510087‐5). Publisher Copyright: © 2020 Wiley-VCH GmbH Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/2/5

Y1 - 2021/2/5

N2 - Many MRI contrast agents formed with the parahydrogen-induced polarization (PHIP) technique exhibit biocompatible profiles. In the context of respiratory imaging with inhalable molecular contrast agents, the development of nonflammable contrast agents would nonetheless be highly beneficial for the biomedical translation of this sensitive, high-throughput and affordable hyperpolarization technique. To this end, we assess the hydrogenation kinetics, the polarization levels and the lifetimes of PHIP hyperpolarized products (acids, ethers and esters) at various degrees of fluorine substitution. The results highlight important trends as a function of molecular structure that are instrumental for the design of new, safe contrast agents for in vivo imaging applications of the PHIP technique, with an emphasis on the highly volatile group of ethers used as inhalable anesthetics.

AB - Many MRI contrast agents formed with the parahydrogen-induced polarization (PHIP) technique exhibit biocompatible profiles. In the context of respiratory imaging with inhalable molecular contrast agents, the development of nonflammable contrast agents would nonetheless be highly beneficial for the biomedical translation of this sensitive, high-throughput and affordable hyperpolarization technique. To this end, we assess the hydrogenation kinetics, the polarization levels and the lifetimes of PHIP hyperpolarized products (acids, ethers and esters) at various degrees of fluorine substitution. The results highlight important trends as a function of molecular structure that are instrumental for the design of new, safe contrast agents for in vivo imaging applications of the PHIP technique, with an emphasis on the highly volatile group of ethers used as inhalable anesthetics.

KW - flammability

KW - fluorine

KW - hyperpolarization

KW - inhalable anesthetics

KW - parahydrogen

UR - http://www.scopus.com/inward/record.url?scp=85097366415&partnerID=8YFLogxK

U2 - 10.1002/chem.202004168

DO - 10.1002/chem.202004168

M3 - Article

C2 - 33112442

AN - SCOPUS:85097366415

VL - 27

SP - 2774

EP - 2781

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 8

ER -

ID: 27450626