Low-Cost High-Pressure Clinical-Scale 50% Parahydrogen Generator Using Liquid Nitrogen at 77 K

Standard

Low-Cost High-Pressure Clinical-Scale 50% Parahydrogen Generator Using Liquid Nitrogen at 77 K. / Chapman, Benjamin; Joalland, Baptiste; Meersman, Collier et al.

In: Analytical Chemistry, Vol. 93, No. 24, 22.06.2021, p. 8476–8483.

Research output: Contribution to journal › Article › peer-review

Harvard

Chapman, B, Joalland, B, Meersman, C, Ettedgui, J, Swenson, RE, Krishna, MC, Nikolaou, P, Kovtunov, KV, Salnikov, OG, Koptyug, IV, Gemeinhardt, ME, Goodson, BM, Shchepin, RV & Chekmenev, EY 2021, 'Low-Cost High-Pressure Clinical-Scale 50% Parahydrogen Generator Using Liquid Nitrogen at 77 K', Analytical Chemistry, vol. 93, no. 24, pp. 8476–8483. https://doi.org/10.1021/acs.analchem.1c00716

APA

Chapman, B., Joalland, B., Meersman, C., Ettedgui, J., Swenson, R. E., Krishna, M. C., Nikolaou, P., Kovtunov, K. V., Salnikov, O. G., Koptyug, I. V., Gemeinhardt, M. E., Goodson, B. M., Shchepin, R. V., & Chekmenev, E. Y. (2021). Low-Cost High-Pressure Clinical-Scale 50% Parahydrogen Generator Using Liquid Nitrogen at 77 K. Analytical Chemistry, 93(24), 8476–8483. https://doi.org/10.1021/acs.analchem.1c00716

Vancouver

Chapman B, Joalland B, Meersman C, Ettedgui J, Swenson RE, Krishna MC et al. Low-Cost High-Pressure Clinical-Scale 50% Parahydrogen Generator Using Liquid Nitrogen at 77 K. Analytical Chemistry. 2021 Jun 22;93(24):8476–8483. Epub 2021 Jun 9. doi: 10.1021/acs.analchem.1c00716

Author

Chapman, Benjamin ; Joalland, Baptiste ; Meersman, Collier et al. / Low-Cost High-Pressure Clinical-Scale 50% Parahydrogen Generator Using Liquid Nitrogen at 77 K. In: Analytical Chemistry. 2021 ; Vol. 93, No. 24. pp. 8476–8483.

BibTeX

@article{b55d6fdee1b04837acafd7ca10646758,

title = "Low-Cost High-Pressure Clinical-Scale 50% Parahydrogen Generator Using Liquid Nitrogen at 77 K",

abstract = "We report on a robust and low-cost parahydrogen generator design employing liquid nitrogen as a coolant. The core of the generator consists of catalyst-filled spiral copper tubing, which can be pressurized to 35 atm. Parahydrogen fraction >48% was obtained at 77 K with three nearly identical generators using paramagnetic hydrated iron oxide catalysts. Parahydrogen quantification was performed on the fly via benchtop NMR spectroscopy to monitor the signal from residual orthohydrogen-parahydrogen is NMR silent. This real-time quantification approach was also used to evaluate catalyst activation at up to 1.0 standard liter per minute flow rate. The reported inexpensive device can be employed for a wide range of studies employing parahydrogen as a source of nuclear spin hyperpolarization. To this end, we demonstrate the utility of this parahydrogen generator for hyperpolarization of concentrated sodium [1-13C]pyruvate, a metabolic contrast agent under investigation in numerous clinical trials. The reported pilot optimization of SABRE-SHEATH (signal amplification by reversible exchange-shield enables alignment transfer to heteronuclei) hyperpolarization yielded 13C signal enhancement of over 14,000-fold at a clinically relevant magnetic field of 1 T corresponding to approximately 1.2% 13C polarization - if near 100% parahydrogen would have been employed, the reported value would be tripled to 13C polarization of 3.5%. ",

author = "Benjamin Chapman and Baptiste Joalland and Collier Meersman and Jessica Ettedgui and Swenson, {Rolf E.} and Krishna, {Murali C.} and Panayiotis Nikolaou and Kovtunov, {Kirill V.} and Salnikov, {Oleg G.} and Koptyug, {Igor V.} and Gemeinhardt, {Max E.} and Goodson, {Boyd M.} and Shchepin, {Roman V.} and Chekmenev, {Eduard Y.}",

year = "2021",

month = jun,

day = "22",

doi = "10.1021/acs.analchem.1c00716",

language = "English",

volume = "93",

pages = "8476–8483",

journal = "Analytical Chemistry",

issn = "0003-2700",

publisher = "American Chemical Society",

number = "24",

}

RIS

TY - JOUR

T1 - Low-Cost High-Pressure Clinical-Scale 50% Parahydrogen Generator Using Liquid Nitrogen at 77 K

AU - Chapman, Benjamin

AU - Joalland, Baptiste

AU - Meersman, Collier

AU - Ettedgui, Jessica

AU - Swenson, Rolf E.

AU - Krishna, Murali C.

AU - Nikolaou, Panayiotis

AU - Kovtunov, Kirill V.

AU - Salnikov, Oleg G.

AU - Koptyug, Igor V.

AU - Gemeinhardt, Max E.

AU - Goodson, Boyd M.

AU - Shchepin, Roman V.

AU - Chekmenev, Eduard Y.

PY - 2021/6/22

Y1 - 2021/6/22

N2 - We report on a robust and low-cost parahydrogen generator design employing liquid nitrogen as a coolant. The core of the generator consists of catalyst-filled spiral copper tubing, which can be pressurized to 35 atm. Parahydrogen fraction >48% was obtained at 77 K with three nearly identical generators using paramagnetic hydrated iron oxide catalysts. Parahydrogen quantification was performed on the fly via benchtop NMR spectroscopy to monitor the signal from residual orthohydrogen-parahydrogen is NMR silent. This real-time quantification approach was also used to evaluate catalyst activation at up to 1.0 standard liter per minute flow rate. The reported inexpensive device can be employed for a wide range of studies employing parahydrogen as a source of nuclear spin hyperpolarization. To this end, we demonstrate the utility of this parahydrogen generator for hyperpolarization of concentrated sodium [1-13C]pyruvate, a metabolic contrast agent under investigation in numerous clinical trials. The reported pilot optimization of SABRE-SHEATH (signal amplification by reversible exchange-shield enables alignment transfer to heteronuclei) hyperpolarization yielded 13C signal enhancement of over 14,000-fold at a clinically relevant magnetic field of 1 T corresponding to approximately 1.2% 13C polarization - if near 100% parahydrogen would have been employed, the reported value would be tripled to 13C polarization of 3.5%.

AB - We report on a robust and low-cost parahydrogen generator design employing liquid nitrogen as a coolant. The core of the generator consists of catalyst-filled spiral copper tubing, which can be pressurized to 35 atm. Parahydrogen fraction >48% was obtained at 77 K with three nearly identical generators using paramagnetic hydrated iron oxide catalysts. Parahydrogen quantification was performed on the fly via benchtop NMR spectroscopy to monitor the signal from residual orthohydrogen-parahydrogen is NMR silent. This real-time quantification approach was also used to evaluate catalyst activation at up to 1.0 standard liter per minute flow rate. The reported inexpensive device can be employed for a wide range of studies employing parahydrogen as a source of nuclear spin hyperpolarization. To this end, we demonstrate the utility of this parahydrogen generator for hyperpolarization of concentrated sodium [1-13C]pyruvate, a metabolic contrast agent under investigation in numerous clinical trials. The reported pilot optimization of SABRE-SHEATH (signal amplification by reversible exchange-shield enables alignment transfer to heteronuclei) hyperpolarization yielded 13C signal enhancement of over 14,000-fold at a clinically relevant magnetic field of 1 T corresponding to approximately 1.2% 13C polarization - if near 100% parahydrogen would have been employed, the reported value would be tripled to 13C polarization of 3.5%.

UR - http://www.scopus.com/inward/record.url?scp=85108716669&partnerID=8YFLogxK

U2 - 10.1021/acs.analchem.1c00716

DO - 10.1021/acs.analchem.1c00716

M3 - Article

C2 - 34102835

AN - SCOPUS:85108716669

VL - 93

SP - 8476

EP - 8483

JO - Analytical Chemistry

JF - Analytical Chemistry

SN - 0003-2700

IS - 24

ER -

ID: 28873897