Standard

Long-wavelength photoremovable protecting groups : On the way to in vivo application. / Vorobev, Aleksey Yu; Moskalensky, Alexander E.

In: Computational and Structural Biotechnology Journal, Vol. 18, 2020, p. 27-34.

Research output: Contribution to journal › Review article › peer-review

Harvard

Vorobev, AY & Moskalensky, AE 2020, 'Long-wavelength photoremovable protecting groups: On the way to in vivo application', Computational and Structural Biotechnology Journal, vol. 18, pp. 27-34. https://doi.org/10.1016/j.csbj.2019.11.007

APA

Vorobev, A. Y., & Moskalensky, A. E. (2020). Long-wavelength photoremovable protecting groups: On the way to in vivo application. Computational and Structural Biotechnology Journal, 18, 27-34. https://doi.org/10.1016/j.csbj.2019.11.007

Vancouver

Vorobev AY, Moskalensky AE. Long-wavelength photoremovable protecting groups: On the way to in vivo application. Computational and Structural Biotechnology Journal. 2020;18:27-34. doi: 10.1016/j.csbj.2019.11.007

Author

Vorobev, Aleksey Yu ; Moskalensky, Alexander E. / Long-wavelength photoremovable protecting groups : On the way to in vivo application. In: Computational and Structural Biotechnology Journal. 2020 ; Vol. 18. pp. 27-34.

BibTeX

@article{b0b867c4ca1a4b3897069d489ac80593,
title = "Long-wavelength photoremovable protecting groups: On the way to in vivo application",
abstract = "Photoremovable protective groups (PPGs) and related “caged” compounds have been recognized as a powerful tool in an arsenal of life science methods. The present review is focused on recent advances in design of “caged” compounds which function in red or near-infrared region. The naive comparison of photon energy with that of organic bond leads to the illusion that long-wavelength activation is possible only for weak chemical bonds like N-N. However, there are different means to overcome this threshold and shift the uncaging functionality into red or near-infrared regions for general organic bonds. We overview these strategies, including the novel photochemical and photophysical mechanisms used in newly developed PPGs, singlet-oxygen-mediated photolysis, and two-photon absorption. Recent advances in science places the infrared-sensitive PPGs to the same usability level as traditional ones, facilitating in vivo application of caged compounds.",
keywords = "caged compounds, long-wavelength excitation, photoremovable protecting groups, DESIGN, CHROMOPHORE, STRATEGY, LIGHT, PHOTORELEASE, REACTIVITY, CAGING GROUP, RELEASE, PLATFORM, PHOTOACTIVATION",
author = "Vorobev, {Aleksey Yu} and Moskalensky, {Alexander E.}",
note = "{\textcopyright} 2019 The Authors.",
year = "2020",
doi = "10.1016/j.csbj.2019.11.007",
language = "English",
volume = "18",
pages = "27--34",
journal = "Computational and Structural Biotechnology Journal",
issn = "2001-0370",
publisher = "Research Network of Computational and Structural Biotechnology",

}

RIS

TY - JOUR

T1 - Long-wavelength photoremovable protecting groups

T2 - On the way to in vivo application

AU - Vorobev, Aleksey Yu

AU - Moskalensky, Alexander E.

N1 - © 2019 The Authors.

PY - 2020

Y1 - 2020

N2 - Photoremovable protective groups (PPGs) and related “caged” compounds have been recognized as a powerful tool in an arsenal of life science methods. The present review is focused on recent advances in design of “caged” compounds which function in red or near-infrared region. The naive comparison of photon energy with that of organic bond leads to the illusion that long-wavelength activation is possible only for weak chemical bonds like N-N. However, there are different means to overcome this threshold and shift the uncaging functionality into red or near-infrared regions for general organic bonds. We overview these strategies, including the novel photochemical and photophysical mechanisms used in newly developed PPGs, singlet-oxygen-mediated photolysis, and two-photon absorption. Recent advances in science places the infrared-sensitive PPGs to the same usability level as traditional ones, facilitating in vivo application of caged compounds.

AB - Photoremovable protective groups (PPGs) and related “caged” compounds have been recognized as a powerful tool in an arsenal of life science methods. The present review is focused on recent advances in design of “caged” compounds which function in red or near-infrared region. The naive comparison of photon energy with that of organic bond leads to the illusion that long-wavelength activation is possible only for weak chemical bonds like N-N. However, there are different means to overcome this threshold and shift the uncaging functionality into red or near-infrared regions for general organic bonds. We overview these strategies, including the novel photochemical and photophysical mechanisms used in newly developed PPGs, singlet-oxygen-mediated photolysis, and two-photon absorption. Recent advances in science places the infrared-sensitive PPGs to the same usability level as traditional ones, facilitating in vivo application of caged compounds.

KW - caged compounds

KW - long-wavelength excitation

KW - photoremovable protecting groups

KW - DESIGN

KW - CHROMOPHORE

KW - STRATEGY

KW - LIGHT

KW - PHOTORELEASE

KW - REACTIVITY

KW - CAGING GROUP

KW - RELEASE

KW - PLATFORM

KW - PHOTOACTIVATION

UR - http://www.scopus.com/inward/record.url?scp=85076046047&partnerID=8YFLogxK

U2 - 10.1016/j.csbj.2019.11.007

DO - 10.1016/j.csbj.2019.11.007

M3 - Review article

C2 - 31890141

AN - SCOPUS:85076046047

VL - 18

SP - 27

EP - 34

JO - Computational and Structural Biotechnology Journal

JF - Computational and Structural Biotechnology Journal

SN - 2001-0370

ER -

ID: 22600273