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Isoxazole-linked 7-hydroxycoumarin–2,6-dimethylheptane conjugates as inhibitors of TDP1 enzyme. / Tsypyshev, Dmitry O.; Zakharenko, Alexandra L.; Podurina, Maria V. et al.

In: Mendeleev Communications, Vol. 35, No. 4, 2025, p. 444-446.

Research output: Contribution to journal › Article › peer-review

Harvard

Tsypyshev, DO, Zakharenko, AL, Podurina, MV, Khomenko, TM, Kondrashov, EV, Lavrik, OI, Volcho, KP & Salakhutdinov, NF 2025, 'Isoxazole-linked 7-hydroxycoumarin–2,6-dimethylheptane conjugates as inhibitors of TDP1 enzyme', Mendeleev Communications, vol. 35, no. 4, pp. 444-446. https://doi.org/10.71267/mencom.7704

APA

Tsypyshev, D. O., Zakharenko, A. L., Podurina, M. V., Khomenko, T. M., Kondrashov, E. V., Lavrik, O. I., Volcho, K. P., & Salakhutdinov, N. F. (2025). Isoxazole-linked 7-hydroxycoumarin–2,6-dimethylheptane conjugates as inhibitors of TDP1 enzyme. Mendeleev Communications, 35(4), 444-446. https://doi.org/10.71267/mencom.7704

Vancouver

Tsypyshev DO, Zakharenko AL, Podurina MV, Khomenko TM, Kondrashov EV, Lavrik OI et al. Isoxazole-linked 7-hydroxycoumarin–2,6-dimethylheptane conjugates as inhibitors of TDP1 enzyme. Mendeleev Communications. 2025;35(4):444-446. doi: 10.71267/mencom.7704

Author

Tsypyshev, Dmitry O. ; Zakharenko, Alexandra L. ; Podurina, Maria V. et al. / Isoxazole-linked 7-hydroxycoumarin–2,6-dimethylheptane conjugates as inhibitors of TDP1 enzyme. In: Mendeleev Communications. 2025 ; Vol. 35, No. 4. pp. 444-446.

BibTeX

@article{cc6cfc45fe9c44ff9d280a09ea7b3936,
title = "Isoxazole-linked 7-hydroxycoumarin–2,6-dimethylheptane conjugates as inhibitors of TDP1 enzyme",
abstract = "Novel monoterpenoid derivatives of 7-hydroxycoumarine containing an isoxazole linker were synthesized, 2,3-dichloropropene having been the synthetic equivalent of propargyl chloride at the step of isoxazole moiety construction. The conjugates demonstrated promising inhibitory activity against TDP1, an important target for complex anticancer therapy, with IC50 values in the low micromolar or submicromolar concentration range.",
keywords = "TDP1, antitumor, biological activity, coumarin, isoxazole, saturated terpenoids, synthesis",
author = "Tsypyshev, {Dmitry O.} and Zakharenko, {Alexandra L.} and Podurina, {Maria V.} and Khomenko, {Tatyana M.} and Kondrashov, {Evgeniy V.} and Lavrik, {Olga I.} and Volcho, {Konstantin P.} and Salakhutdinov, {Nariman F.}",
note = "Isoxazole-linked 7-hydroxycoumarin–2,6-dimethylheptane conjugates as inhibitors of TDP1 enzyme / D. O. Tsypyshev, A. L. Zakharenko, M. V. Podurina, T. M. Khomenko, E. V. Kondrashov, O. I. Lavrik, K. P. Volcho, N. F. Salakhutdinov // Mendeleev Communications. - 2025. - Том 35, выпуск 4. - С. 444–446. DOI: https://doi.org/10.71267/mencom.7704",
year = "2025",
doi = "10.71267/mencom.7704",
language = "English",
volume = "35",
pages = "444--446",
journal = "Mendeleev Communications",
issn = "0959-9436",
publisher = "Elsevier Science Publishing Company, Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Isoxazole-linked 7-hydroxycoumarin–2,6-dimethylheptane conjugates as inhibitors of TDP1 enzyme

AU - Tsypyshev, Dmitry O.

AU - Zakharenko, Alexandra L.

AU - Podurina, Maria V.

AU - Khomenko, Tatyana M.

AU - Kondrashov, Evgeniy V.

AU - Lavrik, Olga I.

AU - Volcho, Konstantin P.

AU - Salakhutdinov, Nariman F.

N1 - Isoxazole-linked 7-hydroxycoumarin–2,6-dimethylheptane conjugates as inhibitors of TDP1 enzyme / D. O. Tsypyshev, A. L. Zakharenko, M. V. Podurina, T. M. Khomenko, E. V. Kondrashov, O. I. Lavrik, K. P. Volcho, N. F. Salakhutdinov // Mendeleev Communications. - 2025. - Том 35, выпуск 4. - С. 444–446. DOI: https://doi.org/10.71267/mencom.7704

PY - 2025

Y1 - 2025

N2 - Novel monoterpenoid derivatives of 7-hydroxycoumarine containing an isoxazole linker were synthesized, 2,3-dichloropropene having been the synthetic equivalent of propargyl chloride at the step of isoxazole moiety construction. The conjugates demonstrated promising inhibitory activity against TDP1, an important target for complex anticancer therapy, with IC50 values in the low micromolar or submicromolar concentration range.

AB - Novel monoterpenoid derivatives of 7-hydroxycoumarine containing an isoxazole linker were synthesized, 2,3-dichloropropene having been the synthetic equivalent of propargyl chloride at the step of isoxazole moiety construction. The conjugates demonstrated promising inhibitory activity against TDP1, an important target for complex anticancer therapy, with IC50 values in the low micromolar or submicromolar concentration range.

KW - TDP1

KW - antitumor

KW - biological activity

KW - coumarin

KW - isoxazole

KW - saturated terpenoids

KW - synthesis

UR - https://www.mendeley.com/catalogue/1841c1e8-68ea-31c7-98d8-71d74b11cb69/

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-105007471982&origin=inward&txGid=e17c7da58301bf955ea8ef4846e48b75

U2 - 10.71267/mencom.7704

DO - 10.71267/mencom.7704

M3 - Article

VL - 35

SP - 444

EP - 446

JO - Mendeleev Communications

JF - Mendeleev Communications

SN - 0959-9436

IS - 4

ER -

ID: 67902830