Research output: Contribution to journal › Article › peer-review
Invisible but Insidious Effects of Microplastics. / Stefanova, Natalia A.; Sotnikova, Yulia S.; Osechkova, Aleksandra E. et al.
In: Molecules, Vol. 29, No. 23, 5776, 12.2024.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Invisible but Insidious Effects of Microplastics
AU - Stefanova, Natalia A.
AU - Sotnikova, Yulia S.
AU - Osechkova, Aleksandra E.
AU - Karpova, Elena V.
AU - Polovyanenko, Dmitriy N.
AU - Fursova, Anzhella Zh
AU - Kiseleva, Daria A.
AU - Tolstikova, Tatyana G.
AU - Kolosova, Nataliya G.
AU - Bagryanskaya, Elena G.
N1 - This study was supported by Ministry of Science and Higher Education of the Russian Federation within the framework of state assignments of the N.N. Vorozhtsov Institute of Organic Chemistry (FWUE-2022-0005).
PY - 2024/12
Y1 - 2024/12
N2 - Increasing evidence on the adverse health impacts of microplastics (MPs) is available, but their associated risks to the well-being of humans and long-term impacts are poorly understood. An indicator of the remote effects of MPs may be their influence on the rate of aging. To assess the effects of MPs on the aging process, we used accelerated senescence OXYS rats that develop a complex of geriatric diseases. We prepared the polyethylene terephthalate MPs (2–6 microns in size) and in OXYS and Wistar (maternal strain) rats assessed the influence of chronic administration of MPs (10 or 100 mg/kg per day from age 1.5 to 3.5 months,) on the hematological and biochemical blood parameters, spatial learning, and memory. In addition, the effects of MPs on the development of cataracts and retinopathy, similar to age-related macular degeneration (AMD), in OXYS rats were assessed. We found that in the absence of significant changes in standard clinical blood parameters, chronic MP administration negatively affected the cognitive functions of both Wistar rats and OXYS rats. Additionally, a dose of 100 mg/kg MPs contributed to cataract and AMD progression in OXYS rats. Our results suggest that MPs may increase the rate of aging and, in the long term, lifespan.
AB - Increasing evidence on the adverse health impacts of microplastics (MPs) is available, but their associated risks to the well-being of humans and long-term impacts are poorly understood. An indicator of the remote effects of MPs may be their influence on the rate of aging. To assess the effects of MPs on the aging process, we used accelerated senescence OXYS rats that develop a complex of geriatric diseases. We prepared the polyethylene terephthalate MPs (2–6 microns in size) and in OXYS and Wistar (maternal strain) rats assessed the influence of chronic administration of MPs (10 or 100 mg/kg per day from age 1.5 to 3.5 months,) on the hematological and biochemical blood parameters, spatial learning, and memory. In addition, the effects of MPs on the development of cataracts and retinopathy, similar to age-related macular degeneration (AMD), in OXYS rats were assessed. We found that in the absence of significant changes in standard clinical blood parameters, chronic MP administration negatively affected the cognitive functions of both Wistar rats and OXYS rats. Additionally, a dose of 100 mg/kg MPs contributed to cataract and AMD progression in OXYS rats. Our results suggest that MPs may increase the rate of aging and, in the long term, lifespan.
KW - Alzheimer’s disease
KW - OXYS rats
KW - age-related macular degeneration
KW - cognitive ability
KW - memory
KW - microplastic
KW - polymers
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85211824969&origin=inward&txGid=6d0f6fe3b6816d11335ec08a3a5e1b7b
UR - https://www.mendeley.com/catalogue/ece18e98-ca84-33ae-b577-8675b160d4c2/
U2 - 10.3390/molecules29235776
DO - 10.3390/molecules29235776
M3 - Article
C2 - 39683933
VL - 29
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 23
M1 - 5776
ER -
ID: 61280904