TY - JOUR

T1 - Investigation of thermal effects of radiofrequency ablation mediated with iron oxide nanoparticles dispersed in agarose and chitosan solvents

AU - Ashikbayeva, Zhannat

AU - Aitkulov, Arman

AU - Wolf, Alexey

AU - Dostovalov, Alexander

AU - Amantayeva, Aida

AU - Kurbanova, Aliya

AU - Inglezakis, Vassilis J.

AU - Tosi, Daniele

N1 - Funding Information: Funding: The research was funded mainly by Nazarbayev University, under grants SMARTER (code: 091019CRP2117) and EPICGuide (code: 240919FD3908). A.W. and A.D. acknowledge the support of the Ministry of Education and Science of the Russian Federation (14.Y26.31.0017). Funding Information: Acknowledgments: The research was funded mainly by Nazarbayev University, under grants SMARTER (code: 091019CRP2117) and EPICGuide (code: 240919FD3908). A.W. and A.D. acknowledge the support of the Ministry of Education and Science of the Russian Federation (14.Y26.31.0017). Authors acknowledge D. Balmassov for the support in drawing Figures 1 and 12. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/3/1

Y1 - 2021/3/1

N2 - Thermal ablation (TA) is known as an alternative therapy to surgery to treat tumors. However, TA-based therapy requires advanced approaches in order to prevent causing damage to healthy tissue around the tumor and selectively target the desired area. Nanoparticles are considered as a promising tool in biomedicine to fulfill these requirements. This study was carried out in order to analyze the effect of iron oxide nanoparticles on the temperature increment during radiofrequency ablation therapy of porcine liver. In addition, this research aimed to experimentally evaluate the impact of two solvents such as agarose and chitosan on the temperature change, when magnetic nanoparticles were dispersed in them. The iron oxide nanoparticles were synthesized by the solvothermal method demonstrating the magnetic properties by acting to the external magnetic field. To increase the local heat superparamagnetic nanoparticles (iron oxide magnetic nanoparticle (IONPs)) of the average size of 20 nm in size and the concentrations from 1 to 10 mg/mL of MNPs with a step size of 1 mg/mL were tested in 10 replicates for each concentration and solvent. Moreover, the temperature changes for dry liver, and 0 mg/mL concentration was checked for calibration and reference purposes. As a sensing system, advanced 16-FBG optical fiber sensors connected to an interrogator were employed allowing the temperature change to be monitored accurately in real time. A maximum temperature of about 142◦ C was recorded by a 5 mg/mL concentration of iron oxide nanoparticles dispersed in the agarose solvent.

AB - Thermal ablation (TA) is known as an alternative therapy to surgery to treat tumors. However, TA-based therapy requires advanced approaches in order to prevent causing damage to healthy tissue around the tumor and selectively target the desired area. Nanoparticles are considered as a promising tool in biomedicine to fulfill these requirements. This study was carried out in order to analyze the effect of iron oxide nanoparticles on the temperature increment during radiofrequency ablation therapy of porcine liver. In addition, this research aimed to experimentally evaluate the impact of two solvents such as agarose and chitosan on the temperature change, when magnetic nanoparticles were dispersed in them. The iron oxide nanoparticles were synthesized by the solvothermal method demonstrating the magnetic properties by acting to the external magnetic field. To increase the local heat superparamagnetic nanoparticles (iron oxide magnetic nanoparticle (IONPs)) of the average size of 20 nm in size and the concentrations from 1 to 10 mg/mL of MNPs with a step size of 1 mg/mL were tested in 10 replicates for each concentration and solvent. Moreover, the temperature changes for dry liver, and 0 mg/mL concentration was checked for calibration and reference purposes. As a sensing system, advanced 16-FBG optical fiber sensors connected to an interrogator were employed allowing the temperature change to be monitored accurately in real time. A maximum temperature of about 142◦ C was recorded by a 5 mg/mL concentration of iron oxide nanoparticles dispersed in the agarose solvent.

KW - Fiber Bragg grating (FBG)

KW - Iron oxide magnetic nanoparticles

KW - Optical fiber

KW - Radiofrequency ablation

KW - The sensing system

UR - http://www.scopus.com/inward/record.url?scp=85102958627&partnerID=8YFLogxK

U2 - 10.3390/app11052437

DO - 10.3390/app11052437

M3 - Article

AN - SCOPUS:85102958627

VL - 11

JO - Applied Sciences (Switzerland)

JF - Applied Sciences (Switzerland)

SN - 2076-3417

IS - 5

M1 - 2437

ER -